Adiponectin/leptin and HOMA/adiponectin ratios in Iranian women with polycystic ovary syndrome

Vatannejad, Akram; Kheirollahi, Asma

doi:10.1007/s11845-023-03408-4

Cited by 2 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Women with PCOS have significantly decreased adiponectin levels [69][70][71][72] linked to increased inflammation and higher adipokine levels 73 , implying that dyslipidemia is directly associated with inflammation. Women with PCOS have considerably lower Adiponectin/ Leptin (A/L) and higher HOMA/Adiponectin (H/A) ratios, respectively 74 . A recent study demonstrated that the A/L ratio is markedly reduced in women with PCOS; however, there is no correlation with BMI or IR 75 .…”

Section: Adiponectin and Pcosmentioning

confidence: 99%

Adipose Tissue Dysfunction in PCOS

Aparupa,

Singh

2024

JER

View full text Add to dashboard Cite

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age; however, its aetiology is unclear. PCOS is linked to many metabolic manifestations and alterations such as obesity, insulin resistance, and cardiovascular diseases (CVD). Women with PCOS have intra-ovarian and systemic changes in their metabolite levels. Adipose tissue dysfunction plays a significant role in the pathophysiology of PCOS. Adipose tissue growth is disrupted by metabolic stress, leading to hypertrophy of adipocytes, which begin to express stress signals. Adipose tissue secretes autocrine and paracrine factors, called adipokines or adipocytokines. Adiponectin is an adipocyte-derived protein abundant in the bloodstream. Plasma adiponectin concentration is low in women with PCOS, obesity, CVD, and hypertension. Other adipocytokines with altered secretion in PCOS include leptin, resistin, apelin, visfatin, IL-6, IL-8, and TNF-α. Hormonal imbalance, untimely action of high LH, and consequent hyperandrogenism in women with PCOS may cause metabolic defects associated with adipose tissue dysfunction; however, there are no reports on the role of higher LH levels in adipose dysfunction and altered adipokine secretion. New medications with therapeutic potential have been developed that target adipokines for the treatment of PCOS. This review discusses the association between PCOS and altered adipokine production as a consequence of adipose dysfunction.

show abstract

Section: Adiponectin and Pcosmentioning

confidence: 99%

Adipose Tissue Dysfunction in PCOS

Aparupa,

Singh

2024

JER

View full text Add to dashboard Cite

show abstract

“…Recent studies have highlighted the involvement of genetics, epigenetic changes, environmental factors, oxidative stress, chronic lowgrade inflammation, mitochondrial dysfunction, and metabolic disorder in the pathogenesis of PCOS (3)(4)(5)(6). The pathogenesis of PCOS shares common features with metabolic syndrome (MetS) including dysfunctional adipose tissue, obesity, insulin resistance (IR), and an increased risk of developing type II diabetes mellitus (T2DM), cardiovascular disease, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD) (7)(8)(9). PCOS is a complex condition characterized by the presence of at least two of three Rotterdam criteria, which include hyperandrogenism (manifested as hirsutism or hyperandrogenaemia), oligo-ovulation or anovulation, and polycystic ovarian morphologic (PCOM) features (10,11).…”

mentioning

confidence: 99%

Changes of biochemical parameters in normal weight and overweight/obese women with polycystic ovary Syndrome

Narani,

Vatannejad,

Kheirollahi

et al. 2023

ABI

View full text Add to dashboard Cite

Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disease in reproductiveage women, which interferes with fertility, menstruation, and body composition. Some biochemical parameters change in women with PCOS, a feature which can be a consequence of the disease itself or of the accompanying obesity. This study investigated the glucose and lipid profiles, sex hormones, and hsCRP in normal weight and overweight/ obese Iranian women with and without PCOS. Methods: 314 women with PCOS and 138 healthy and fertile women were recruited for the study. The patients and controls were divided according to body mass index (BMI) into two groups as follows: BMI<25 Kg/m2 and BMI≥ 25 Kg/m2 . Blood samples were collected from all participants to assess fasting blood glucose, fasting insulin, lipid profile, FSH, LH, free testosterone, and hs-CRP levels. The homeostasis model of insulin resistance (HOMA-IR) was calculated for assessing insulin sensitivity. Results: BMI, fasting insulin, HOMA-IR, triglyceride, FT, LH, and hs-CRP levels were significantly higher in the PCOS group, while lower levels of FSH were observed in comparison to non-PCOS women. Among overweight PCOS women, hs-CRP levels were significantly elevated compared to normal-weight PCOS women. However, there was no significant difference in circulating hs-CRP levels between normal-weight and overweight participants in the control group. Conclusion: The study results suggest that both insulin resistance and an increase in hs-CRP may be relevant to PCOS. Moreover, the findings indicated that chronic inflammation in PCOS is not solely dependent on the pathogenesis of the disease but may be exacerbated by increased body weight.

show abstract

Adiponectin/leptin and HOMA/adiponectin ratios in Iranian women with polycystic ovary syndrome

Cited by 2 publications

References 33 publications

Adipose Tissue Dysfunction in PCOS

Adipose Tissue Dysfunction in PCOS

Changes of biochemical parameters in normal weight and overweight/obese women with polycystic ovary Syndrome

Contact Info

Product

Resources

About