Adiponectin: Its role in obesity-associated colon and prostate cancers

Muppala, Santoshi; Konduru, Siva; Merchant, Neha; Ramsoondar, Judy; Rampersad, Carlos Karan; Rajitha, Balney; Mukund, Vidya; Kancherla, Jyothsna; Hammond, Anthea L.; Barik, Tapan Kumar; Mannarapu, Mastan; Alam, Afroz; Basha, Riyaz; Bramhachari, Pallaval Veera; Verma, Deepika; Sushma, Pinninti Santosh; Pattnaik, Subasini; Nagaraju, Ganji Purnachandra

doi:10.1016/j.critrevonc.2017.06.003

Cited by 38 publications

(35 citation statements)

References 82 publications

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“…Adiponectin is one of the proteins most abundantly secreted by adipose tissue and is an adipokine that has been reported to be associated with CRC . However, to date, the role of adiponectin in cancer is pleiotropic and remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer

Choe

Chai

et al. 2018

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer

Choe

Chai

et al. 2018

Journal of Surgical Oncology

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“…With there being limited success with current therapeutic agents one current use for APN is as prognostic markers for cancer [215] . Both serum APN levels, the expression of AdipoR1/R2, and SNPs could all provide avenues for prognostic and predictive molecular tests in cancer.…”

Section: Future Implications Of Interfering With the Apn Pathway On Cmentioning

confidence: 99%

Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target

Monks¹,

Irakleidis²,

Peng³

2019

JCMT

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Obesity has the far reaching consequence on cancer pathogenesis and immune reactions. In particular, adiponectin (APN) produced by adipocytes played an important role in modulating obesity related malignancies. Via its interaction with corresponding receptors and their downstream signalling pathways, it regulates cells survival, apoptosis and cancer metastasis. Our review dissects the clinical evidence on how hypoadiponectinaemia associated with the increased risks of several cancers and the long-term prognosis and also addresses the controversies. APN also has its indirect effect on anti-cancer immune response which may influence the disease process. We also analyse the impact of APN on the immune system, the anti-tumour responses and the controversies surrounding this area. Targeting therapeutics on APN and its receptor axis represents a promising and novel anti-cancer treatment. Biological understanding of how APN and its interaction with its receptors may affect the immune reactivity. Careful strategizing the use of APN therapeutics in cancer treatment is important, as the APN receptor signalling on the immune cells can blunt anti-tumour response. Targeting APN or its receptors has an enormous implication for the treatment of cancers.

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“…Existem evidências crescentes de que fatores alimentares podem desempenhar papel relevante tanto no desenvolvimento, quanto na prevenção do câncer de mama. Em uma revisão sistemática realizada por Rossi e colaboradores (2014), o alto consumo de carne vermelha, de gordura, triglicérides e colesterol total foi associado ao aumento do risco do câncer de mama (ROSSI et al, 2014). Em nosso estudo, o grupo de mulheres com câncer de mama, quando comparado com o grupo de mulheres sem câncer de mama, apresentou maior consumo médio de gordura saturada, apesar de possuir menor valor de consumo de gordura total.…”

Section: Autor Anounclassified

Importância Da Vacinação Contra O Vírus HPV E Sua Relação Com O Câncer Do Colo Do Útero

Filho¹,

Caracas²,

Rocha³

et al. 2019

Prevenção E Promoção De Saúde 8

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Adiponectin: Its role in obesity-associated colon and prostate cancers

Cited by 38 publications

References 82 publications

Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer

Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer

Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target

Importância Da Vacinação Contra O Vírus HPV E Sua Relação Com O Câncer Do Colo Do Útero

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