Adiponectin is an indicator of insulin resistance in non‐obese prepubertal children born large for gestational age (LGA) and is affected by birth weight

Darendelıler, Feyza; Poyrazoğlu, Şükran; Sancakli, Ozlem; Baş, Firdevs; Gökçay, Gülbin; Aki, Semih; Eskiyurt, Nurten

doi:10.1111/j.1365-2265.2008.03394.x

Cited by 31 publications

(27 citation statements)

References 38 publications

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“…Raised concentrations of split proinsulin in adults have been interpreted as evidence of b-cell dysfunction (Temple et al, 1989) and a risk of impaired glucose tolerance (Hales et al, 1991), but its role as a metabolic marker in infancy has remained poorly understood (Hawdon et al, 1993;Singhal et al, 2003). We found a positive association between the high split proinsulin concentration and the ratio of adipocyte-derived cytokines-leptin and adiponectin-which have been found to correlate with adiposity (Schubring et al, 1999;Mantzoros et al, 2009), and metabolic disorders (Valle et al, 2003;Darendeliler et al, 2009) in newborns and children, and, further, to efficaciously reflect cardio-metabolic risks (Steinberger et al, 2003;Norata et al, 2007). On the other hand, weight status at the age of 6 months predicts obesity in childhood (Taveras et al, 2009), and here abdominal obesity, known to impair b-cell function (Hanley et al, 2002), was linked to the high split proinsulin concentration.…”

Section: Discussionsupporting

confidence: 48%

“…The high 32-33 split proinsulin, a well-characterized predictor of insulin resistance in adults and older children (Temple et al, 1989;Mykkanen et al, 1997;Singhal et al, 2003), was taken as a novel marker of adverse metabolic status in infancy. To further investigate the infants' metabolic status and the usefulness of high split proinsulin in its assessment, waist circumference, skinfold thickness and adipocyte-derived cytokines-leptin and adiponectin- (Shea et al, 2003;Valle et al, 2003;Darendeliler et al, 2009;Corvalan et al, 2010) were taken as secondary outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

et al. 2010

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Objectives: To evaluate the impact of maternal diet and intensive dietary counselling during pregnancy and breastfeeding on the infant's metabolic status. Subjects/Methods: At the first trimester of pregnancy, 256 women were randomized into a control/placebo group and two dietary counselling groups (diet/probiotics and diet/placebo). The counselling, with double-blind randomization to probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis) or placebo, targeted excessive saturated fat and low fibre consumption. Maternal diet was evaluated repeatedly during pregnancy and postpartum by means of 3 days' food diaries. Metabolic markers, serum 32-33 split and intact proinsulin, leptin/adiponectin ratio, skinfold thickness and waist circumference were measured of 194 healthy infants at the age of 6 months, and the high levels were taken to mirror adverse metabolic status. Results: The proportion of infants with a high 32-33 split proinsulin was significantly lower in dietary counselling with probiotics (n ¼ 6/62, 9.7%) or placebo (n ¼ 7/69, 10.1%) compared with the control/placebo group (n ¼ 17/63, 27.0%). The high split proinsulin was associated with larger skinfold thickness, waist circumference and higher leptin/adiponectin ratio in the infants (Po0.05). With respect to maternal diet during pregnancy, the highest and lowest tertiles of fat intake increased the infant's risk of high split proinsulin, whereas those of butter associated correspondingly with the infant's waist circumference. Further, breastfed infants showed a reduced risk of high split proinsulin and leptin/adiponectin ratio compared with formula-fed infants. Conclusions: Modification of maternal diet during pregnancy and breastfeeding may benefit infant metabolic health. High split proinsulin reflects adverse metabolic status in infancy, which can be improved by early dietary counselling.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

et al. 2010

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“…There are two controversial studies on adiponectin levels in a relatively small number of prepubertal LGA children. One of them showed higher IR and lower adiponectin levels in Turkish nonobese prepubertal LGA than AGA children with similar BMI (37). However, a similar study in Greek prepubertal children found higher adiponectin levels in LGA subjects (38).…”

Section: Discussionmentioning

confidence: 84%

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Bueno

Espineira²,

Fernandes-Rosa³

et al. 2010

European Journal of Endocrinology

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Objective: To assess whether the K11391GOA polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life. Design: Case-control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date. Methods: ADIPOQ K11391GOA genotype-phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8-10 years (catch-down growth), and at 23-25 years of age (cardiometabolic profile). Results: The K11391A variant allele frequency was higher in LGA subjects (PZ0.04). AA genotype was associated with augmented probability of being born LGA (odds ratioZ4.14; 95% confidence interval: 1.16-16.7; PZ0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23-25 years, the K11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7G6.2 versus GA: 12.2G6.5 versus AA: 14.2 G6.8 mg/ml; P!0.01). Subjects born LGA presented higher body mass index (BMI; PZ0.01), abdominal circumference (PZ0.04), blood pressure (PZ0.04), and homeostasis assessment model for insulin resistance (PZ0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P!0.001) at 23-25 years. Conclusions: The K11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.

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“…71,72 On the other hand, Darendeliler et al have found that LGA children have higher insulin and lower adiponectin levels than AGA children in spite of similar BMI. 73 A study enrolling 52 young adult offspring of obese mothers and 15 offspring of normal weight mothers demonstrated that the former are more likely to be obese and develop insulin resistance than the latter. 74 Of note, higher maternal pre-pregnancy BMI has been associated with higher offspring systolic and diastolic blood pressure, insulin and triglyceride levels and lower HDL cholesterol at 32 years of age.…”

Section: The Influence Of Maternal Obesity On Fetal Development and Imentioning

confidence: 99%

Effect of maternal obesity on pregnancy outcomes and long-term metabolic consequences

Valsamakis¹,

Kyriazi²,

Mouslech³

et al. 2015

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Adiponectin is an indicator of insulin resistance in non‐obese prepubertal children born large for gestational age (LGA) and is affected by birth weight

Abstract: LGA children have higher insulin and lower adiponectin levels than AGA children in spite of similar BMI. Adiponectin is a better indicator of insulin resistance in LGA children at prepubertal ages and is affected by birth weight.

Cited by 31 publications

References 38 publications

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Effect of maternal obesity on pregnancy outcomes and long-term metabolic consequences

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