Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study

Teixeira, Leonardo Augusto Costa; Santos, Jousielle Márcia dos; Parentoni, Adriana Netto; Lima, Liliana Pereira; Duarte, Tamiris Campos; Brant, Franciane Pereira; Neves, Camila Danielle Cunha; Pereira, Fabiana Souza Máximo; Avelar, Núbia Carelli Pereira de; Danielewicz, Ana Lúcia; Leopoldino, Amanda Aparecida Oliveira; Costa, Sabrina Paula; Arrieiro, Arthur Nascimento; Soares, Luana Aparecida; Prates, Ana Caroline Negreiros; Nobre, Juliana Nogueira Pontes; Bastone, Alessandra de Carvalho; Oliveira, Vinícius Cunha; Oliveira, Murilo Xavier; Figueiredo, Pedro Henrique Scheidt; Costa, Henrique Silveira; Mendonça, Vanessa Amaral; Taı̈ar, Redha; Lacerda, Ana Cristina Rodrigues

doi:10.3390/jcm11237175

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…A UK cohort study including 336 community-dwelling elderly men and women demonstrated that an elevated IL-8 level was associated with an increased risk of sarcopenia (Oflazoglu et al, 2020 ). Consistent with this, several clinical studies have shown that sarcopenia in the elderly had higher levels of IL-8 compared with the non-sarcopenia group (Fan et al, 2022 ; Teixeira et al, 2022 ). Interestingly, IL-8 is also identified as a biomarker during AD progression (Swardfager et al, 2010 ; Alsadany et al, 2013 ).…”

Section: Potential Mechanisms Of Skeletal Muscle–brain Crosstalk In C...supporting

confidence: 54%

Muscle–Brain crosstalk in cognitive impairment

Han

Ashraf

Tipparaju

et al. 2023

Front. Aging Neurosci.

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Sarcopenia is an age-related, involuntary loss of skeletal muscle mass and strength. Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. To date, no effective cures for sarcopenia and AD are available. Physical and cognitive impairments are two major causes of disability in the elderly population, which severely decrease their quality of life and increase their economic burden. Clinically, sarcopenia is strongly associated with AD. However, the underlying factors for this association remain unknown. Mechanistic studies on muscle–brain crosstalk during cognitive impairment might shed light on new insights and novel therapeutic approaches for combating cognitive decline and AD. In this review, we summarize the latest studies emphasizing the association between sarcopenia and cognitive impairment. The underlying mechanisms involved in muscle–brain crosstalk and the potential implications of such crosstalk are discussed. Finally, future directions for drug development to improve age-related cognitive impairment and AD-related cognitive dysfunction are also explored.

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Section: Potential Mechanisms Of Skeletal Muscle–brain Crosstalk In C...supporting

confidence: 54%

Muscle–Brain crosstalk in cognitive impairment

Han

Ashraf

Tipparaju

et al. 2023

Front. Aging Neurosci.

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“…Inflammatory biomarkers that indicate muscle catabolism are highly correlated with frailty in multimorbid patients 38 , and previous studies have associated adiponectin levels with reduced appendicular muscle mass independent of body fat in older women 39 . It is crucial to consider the algorithm employed in our sample for evaluating screening procedures based on handgrip strength, being muscle mass or physical performance is a secondary component in determining Sarcopenia.…”

Section: Discussionmentioning

confidence: 94%

Inflammatory biomarkers at different stages of Sarcopenia in older women

Teixeira

Avelar

Peixoto

et al. 2023

Sci Rep

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In recent years, studies have found that Sarcopenia alters inflammatory biomarkers. However, the behavior of inflammatory biomarkers at different stages of Sarcopenia is not well understood. This study aimed to compare a broad panel of inflammatory biomarkers in older women at different stages of Sarcopenia. The study included 71 Brazilian community-dwelling older women. Muscle Strength was assessed by using handgrip strength (Jamar dynamometer). The Short Physical Performance Battery (SPPB) was performed to assess the physical performance, and body composition was assessed by DEXA. Sarcopenia was diagnosed and classified according to the EWGSOP2 criteria. Blood was drawn, and inflammatory biomarkers associated with Sarcopenia (IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF, adiponectin, leptin, resistin, BDNF, sTNFr-1 and sTNFr-2) was analysed. After diagnosis and classification of sarcopenia, 45% of women did not present Sarcopenia (NS, N = 32), 23.9% were diagnosed with Sarcopenia Probable (SP, N = 17), 19,7% with Sarcopenia Confirmed (SC, N = 14), and 11.3% with Severe Sarcopenia (SS, N = 8). The analysis of inflammatory biomarkers revealed that the more advanced the stage of Sarcopenia, the higher the levels of BDNF, IL-8, sTNFr-1, and sTNFr-2. The assessment of BDNF, IL-8, sTNFr-1, and sTNFr-2 levels may be an adjuvant tool in diagnosis and severity classification of Sarcopenia in older Brazilian women.

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“…On the third visit, which took place 24 h after the body composition and physical tests, blood samples were collected from the participants for the analysis of inflammatory biomarkers. Sampling information and procedures is also available in elsewhere 21 , 22 .…”

Section: Methodsmentioning

confidence: 99%

Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women

da Costa Teixeira,

Soares,

Lima

et al. 2024

Sci Rep

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Considering the challenge that cognitive dysfunction and dementia represent to health is imperative to prioritize early diagnosis strategies and explore the pathophysiological mechanisms. There is no consensus on specific markers and physical tests that indicate cognitive decline in older. The objective of this study was to evaluate a panel of inflammatory biomarkers and physical function and investigate their association with cognitive function in community-dwelling older women. Seventy-one participants were included in this study. Cognitive function was assessed by Mini Mental State Examination, muscle strength using dynamometer, body composition using Dual X-ray absorptiometry, respiratory muscle strength using manuvacuometer, and physical function using the Short Physical Performance Battery and Time Up and Go (TUG) tests. Blood samples were collected to analyze a panel of inflammatory biomarkers. The cognitive function was associated with TUG (β = − 0.48; 95%IC = − 0.54 to − 0.21; p < 0.001), inspiratory muscle strength (β = 0.30; 95%IC = 0.005–0.03; p = 0.009), and leptin concentrations (β = 0.32; 95% IC = 0.001–0.006; 0.007). Time spent on TUG test and leptin levels accounted for 27% of variability in cognitive function independent of age. Poorer physical function with leptin plasma levels is associated with decreased cognitive function in older women. These findings contribute to comprehension of pathophysiology underlying cognitive decline and informing the development of new approaches to prevent, diagnose, monitoring and treat cognitive decline in aging.

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Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study

Cited by 7 publications

References 33 publications

Muscle–Brain crosstalk in cognitive impairment

Muscle–Brain crosstalk in cognitive impairment

Inflammatory biomarkers at different stages of Sarcopenia in older women

Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women

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