Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR

Järvenpää, Jouko; Vuoristo, Jussi; Santaniemi, Merja; Ukkola, Olavi; Savolainen, Eeva‐Riitta; Jääskeläinen, Minna; Tapanainen, Juha S.; Kesäniemi, Antero; Ryynänen, Markku

doi:10.1515/jpm.2009.046

Cited by 21 publications

(14 citation statements)

References 40 publications

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“…Also Yang et al reported the ability of adiponectin to promote endothelial differentiation in peripheral blood CD14þ monocytes, by inducing morphology changes and upregulating EC markers [76]. On the contrary, in other studies it has been reported an ''anti-endothelial action'' for the adipokine, which was shown to increases the caspase-mediated apoptosis in endothelial cells [77,78]. To our knowledge, no studies describe the effect of adiponectin on blood vessels of chorionic villi.…”

Section: Adipokines and Placentamentioning

confidence: 94%

Adipokines, an adipose tissue and placental product with biological functions during pregnancy

et al. 2012

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Latter half of pregnancy is characterized by a "physiological diabetogenic state" since changes in insulin-sensitivity have been well documented. These changes ensure continuous supply of nutrients to the growing fetus. In the last years the role of adipocyte-derived signaling molecules, collectively known as adipokines has been object of different in vitro and in vivo studies. Of interest, adipokines and/or their receptors are expressed in the placental tissue which, therefore, can contribute to development of maternal insulin-resistance and, as a consequence, fetal growth. Leptin, adiponectin, and resistin represent the most well studied adipokines and, with the exception of adiponectin, their serum and placental levels increase as pregnancy progresses. High levels of adipokines have also been detected in umbilical plasma hence suggesting a possible role on fetal development and metabolism; however, it remains still unclear if such adipokines can directly stimulate fetal tissues development acting as growth factors. In addition to their well known metabolic effects, we also reported studies describing the role of adipokines in promoting proliferation and invasiveness of trophoblast cells and affecting local angiogenic processes. These observations strongly suggest that adipokines, by alternatively interfering with placental development, may affect pregnancy outcome and fetal growth. However, further studies are needed to better understand the local regulation of their expression. © 2012 International Union of Biochemistry and Molecular Biology, Inc.

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Section: Adipokines and Placentamentioning

confidence: 94%

Adipokines, an adipose tissue and placental product with biological functions during pregnancy

et al. 2012

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“…Leptin also affects the expression of several genes involved in angiogenesis such as matrix metalloproteinase (MMP)-2 and -9 (Cao et al, 2001). Leptin was implicated in the pathogenesis of several diseases, including essential hypertension and preeclampsia; recently, several groups reported increased serum and placental leptin levels in preeclamptic patients (Jarvenpaa et al, 2009). However, it is unknown whether elevated leptin levels are the causes or consequences of preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia

Wang¹,

Qiao²,

Li³

2013

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and Lys656Asn + Asn656Asn frequencies in the LEPR gene were significantly more prevalent in preeclampsia mothers than in controls (P < 0.05). The serum leptin levels of preeclampsia cases were significantly higher than those of controls. In addition, there were higher serum leptin levels in individuals with the GC + CC genotype both in the total cohort and in women with preeclampsia than in those with the GG genotype. Our findings suggest that the Lys656Asn polymorphism is a functional variant in the LEPR, which can affect the interaction of leptin and its receptor. Furthermore, high leptin level and the LEPR variant are risk factors for preeclampsia in Chinese women.

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“…проде-монстрировали способность адипонектина усиливать дифференциацию эндотелиальных клеток пупочной вены человека и способствовать ангиогенезу [40]. Другие исследования показали противоположное, «антиэндотелиальное действие» адипонектина, где по-следний увеличивал каспазоопосредованный апоптоз в клетках эндотелия [41].…”

Section: роль адипонектина во время беременностиunclassified

Metabolic disorders in adipocytokine imbalance and gestational complications

Чабанова

Борисовна²,

Mataev³

et al. 2017

Obes. metabol.

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Adipose tissue as an endocrine organ synthesizes a large number of biologically active substances, adipocytokines, which have both local and systemic effects influencing the vascular wall, tissue sensitivity to insulin, glucose metabolism, and systemic inflammation. The data obtained from clinical and experimental studies demonstrate the close relationship between the imbalance of adipocytokines and pregnancy complications such as insulin resistance, gestational diabetes, and preeclampsia. In this connection, close attention of obstetrician-gynecologists and endocrinologists is focused on etiopathogenic aspects of the formation of gestational complications with metabolic disorders caused by an imbalance of adipocytokines with maternal obesity and to the search for markers of these disorders. The review presents the current literature data on adipose tissue hormones and their influence on the course of a gestational process.

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Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR

Abstract: The activity of placental adipocytokines and their receptor genes in severe PE may suggest an important role in placental angiogenesis. Placental apoptosis induced by adiponectin could be mediated via the ADIPOR1-receptor.

Cited by 21 publications

References 40 publications

Adipokines, an adipose tissue and placental product with biological functions during pregnancy

Adipokines, an adipose tissue and placental product with biological functions during pregnancy

High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia

Metabolic disorders in adipocytokine imbalance and gestational complications

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