Adiponectin in male reproduction and infertility

Dutta, Sulagna; Sengupta, Pallav; Biswas, Anupam

doi:10.4103/2305-0500.268153

Cited by 14 publications

(10 citation statements)

References 64 publications

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“…Leptin and adiponectin, as well as estrogen production and their transductional routes, seem to be important for further considerations as potential targets for diagnosis and therapy of Leydig cell tumors and adipose tissue dysfunction [11,72], although more precise analyses e.g., ultrastructural and epigenetical, should be used for precise recognition of subtle differences that can exist in tumor tissue biochemistry between non-obese and obese patients. What is more, special attention should be paid to an explanation of the association of adiponectin, leptin, with infertility and BMI as it is still controversial [73,74].…”

Section: Discussionmentioning

confidence: 99%

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Duliban

Górowska-Wójtowicz

Tworzydło

et al. 2020

IJMS

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Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnosis, and therapy still remains not completely characterized. Our prior studies reported G-protein coupled estrogen receptor signaling and estrogen level disturbances in Leydig cell tumors. In addition, we found that expressions of multi-level-acting lipid balance- and steroidogenesis–controlling proteins including peroxisome proliferator-activated receptor are altered in this tumor. In order to get deeper into the other molecular mechanisms that regulate lipid homeostasis in the Leydig cell tumor, here we investigate the presence and expression of newly-described hormones responsible for lipid homeostasis balancing (leptin and adiponectin), together with expression of estrogen synthase (aromatase). Samples of Leydig cell tumors (n = 20) were obtained from patients (31–45 years old) and used for light and transmission electron microscopic, western blotting, and immunohistochemical analyses. In addition, body mass index (BMI) was calculated. In tumor mass, abundant lipid accumulation in Leydig cells and various alterations of Leydig cell shape, as well as the presence of adipocyte-like cells, were observed. Marked lipid content and various lipid droplet size, especially in obese patients, may indicate alterations in lipid homeostasis, lipid processing, and steroidogenic organelle function in response to interstitial tissue pathological changes. We revealed significantly increased expression of leptin, adiponectin and their receptors, as well as aromatase in Leydig cell tumors in comparison to control. The majority of patients (n = 13) were overweight as indicated by their BMI. Moreover, a significant increase in expression of phospholipase C (PLC), and kinases Raf, ERK which are part of adipokine transductional pathways, was demonstrated. These data expand our previous findings suggesting that in human Leydig cell tumors, estrogen level and signaling, together with lipid status, are related to each other. Increased BMI may contribute to certain biochemical characteristics and function of the Leydig cell in infertile patients with a tumor. In addition, altered adipokine-estrogen microenvironment can have an effect on proliferation, growth, and metastasis of tumor cells. We report here various targets (receptors, enzymes, hormones) controlling lipid balance and estrogen action in Leydig cell tumors indicating their possible usefulness for diagnostics and therapy.

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Section: Discussionmentioning

confidence: 99%

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Duliban

Górowska-Wójtowicz

Tworzydło

et al. 2020

IJMS

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“…That study concluded that the presence of testosterone reduced plasma adiponectin levels, this nding con rmed by a cell culture of 3T3-L1 adipocytes exposed to testosterone with resulting decrease in adiponectin concentration in the culture media. That study also suggested the gender in uence on adiponectin may be related to the higher risk of insulin resistance and atherosclerosis in males, as induced by androgens [45][46][47]. However, the physiological mechanism to explain this inverse relationship between adiponectin [mostly of the higher molecular weight (HMW) adiponectin isoform] and testosterone as between women and men is not yet clear [48,49].…”

Section: Discussionmentioning

confidence: 96%

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

González-Torres

González-Silva

Perez-Reyes

et al. 2020

Preprint

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Abstract Background Adiponectin is a biomarker useful for the early diagnosis of obesity-related comorbidities. The Mexican population has one of the highest obesity rates worldwide. The purpose of this study was to determine whether an association exists between adiponectin and certain sociodemographic and nutrition-related factors in young adults. This is perhaps one of only a few studies focused in the Los Altos, Jalisco area, a center for religious and cultural traditions in Mexico. Methods A cross-sectional analysis was conducted from January to November 2019 at the Los Altos University Center. A total of 173 student volunteers participating in the study provided voluntary signed, written consent forms. Sociodemographic data were collected. Biochemical and nutritional assessments were realized after eight hours of fasting. Dietary questionnaires were analyzed using Nutrikcal® software. Total serum adiponectin levels were quantified by enzyme-linked immunosorbent assay. Correlations and multivariate models were computerized by SPSSv20. This research project was approved and registered by the Research and Bioethics Committee of the Los Altos University Center, Mexico. Results According to body mass index (BMI), the incidence of underweight participants was found to be 10.4%, whereas that for overweight and obese patients combined was found to be 23.1%. A positive correlation of serum adiponectin levels was found in the following categories: female gender (r = 0.353, p = 0.01); high-density lipoprotein cholesterol (HDL-c) (r = 0.487, p = 0.01); and fruit intake (r = 0.204, p = 0.031). Multivariate analysis showed that 41.6% of adiponectin levels measured could be explained by gender, glucose, HDL-c, sodium and ascorbic acid consumption (r2 = 0.416, p < 0.01). Conclusions In accordance with the results, the incidence of underweight participants was greater than that expected as contrasted by national reports generated in Mexico. In addition, adiponectin level was found to vary with gender and nutrition-related factors. Further studies should be performed in this population to assess the role of religious and Mexican cultural traditions on health status in an effort to prevent undernutrition and obesity-related morbidity and mortality.

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“…TRs are distributed in most body tissues, including testicular tissue, where any down-regulation of thyroid receptors, decrease Sertoli cells, Leydig cells, and germ cells and lower male fertility (14). T3 appears to be a constituent of the neurological and endocrine systems that governs seasonal cycle of reproduction in different species of animals (23), as well as its responsibility in the cessation of reproduction at the conclusion of the reproductive season (22). Similarly, Krassas and Perros (24) suggested that hyperthyroidism negatively impacts seminal human parameters.…”

Section: Reproductive Hormonesmentioning

confidence: 99%

Effect of experimentally induced prepubertal hyperthyroidism on postubertal reproductive activity in male rats

Mohammad¹,

Al-Saaidi²

2022

IJVS

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This study was carried out to investigate the effect of induced prepubertal hyperthyroidism on the reproductive functions of male rats at the pubertal stage. Hyperthyroidism was induced by supplementing thyroxin in drinking water (0.002% w/v) and drenching of 200 μg/kg body weight. Sixty immature males (aged 50 days) were allocated to control and hyperthyroid (PH) groups, administered with distilled water and thyroxin, respectively. Each group was subdivided into three subgroups, sacrificed after 15 days (C15 and PH15), after administration for 15 days and left without treatment for 15 days (C15+ and PH15+), or after 30 days (C30 and PH30). After each period, body weight and relative weight of genital organs were recorded. Serum concentrations of thyroid stimulating hormone (TSH), thyroxin (TT4), triiodothyronine (TT3), follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone was assessed. The expression levels of testicular inha and thyroid hormone receptor (THR) genes were analyzed. Histopathological examination of testis was studied. Compared with control, PH group male rats showed decreased body weight gain and genital organ weights at all experimental periods, increased levels of serum TT4, TT3, and LH, decreased levels of TSH, FSH, and testosterone, and lower expression levels of testicular inha and THR genes. Testicular sections of PH group male rats, showed reduced germinal epithelium, vacuolation, and decreased the number of spermatocytes and Sertoli cells compared with control. In conclusion, the disturbed fluctuations of sex steroid hormones due to prepubertal hyperthyroidism might cause retardation of the testes' development.

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Adiponectin in male reproduction and infertility

Cited by 14 publications

References 64 publications

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

Effect of experimentally induced prepubertal hyperthyroidism on postubertal reproductive activity in male rats

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