Adiponectin in a Native Canadian Population Experiencing Rapid Epidemiological Transition

Hanley, Anthony J.; Connelly, Philip W.; Harris, Stewart B.; Zinman, Bernard

doi:10.2337/diacare.26.12.3219

Cited by 38 publications

(37 citation statements)

References 45 publications

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“…Treatment with octreotide (or Sandostatin) is accompanied by an increase in total body fat [36]. The serum adiponectin level has been shown to vary inversely with total body fat in large population-based studies [38]. BMI does not distinguish between fat mass and lean body mass.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and Cardiac Hypertrophy in Acromegaly

Gurbulak¹,

Akın²,

Yerlikaya³

et al. 2016

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Adiponectin and Cardiac Hypertrophy in Acromegaly

Gurbulak¹,

Akın²,

Yerlikaya³

et al. 2016

Adv Clin Exp Med

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“…19,40 In these analyses, two (Indians) and three (Native Canadians) factors has been shown with adiponectin loading with the lipids factors. 19,40 Adiponectin clustered with HDL-cholesterol (positive correlation) and triglycerides (inverse correlation), In particular, the positive association with HDL-cholesterol may explain the anti-atherogenetic properties of adiponectin, which may reflect the insulin-sensitizing effects of adiponectin. 40 It is noteworthy, that adiponectin also clustered together with fasting insulin and waist circumference in women in the present study.…”

Section: -14mentioning

confidence: 99%

“…19 Most factor analyses of the metabolic syndrome in different populations have identified between three to four distinct factors including obesity, dyslipidemia, hyperglycemia and hypertension. 38,39 In the present study based on an elderly…”

Section: -14mentioning

confidence: 99%

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Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

et al. 2006

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Background: In men, high adiponectin concentrations were related to a lower risk of myocardial infarction, whereas no association with cardiovascular events was found in women. Objective: To investigate sex differences in the associations of adiponectin with cardiovascular risk factors. Design: Cross-sectional population-based KORA Survey 2000 in Southern Germany using the same study methods for cardiovascular risk factors as the former WHO MONICA project. Participants: A total of 697 men and 657 women, aged 55-74 years. Glucose tolerance status was assessed by oral glucose tolerance tests. Results: Adiponectin (geometric mean, interquartile range; mg/ml) levels were significantly higher in women (11.1; 8.5-14.9) than in men (7.1; 5.2-9.6) (Po0.05). In univariate analyses, HDL-cholesterol and age were significantly positively correlated with adiponectin in both sexes. Negative correlations were observed with BMI, waist circumference, fasting and postchallenge glucose, insulin, HOMA-IR, HbA1c, triglycerides, uric acid and CRP (Po0.01). In sex-specific multivariate regression, age and HDL-cholesterol were independently positively, and fasting insulin and 2-h glucose were negatively related to adiponectin in both sexes. Uric acid was significantly inversely related to adiponectin in women only (sex interaction: P ¼ 0.02). Exploratory sex-specific factor analysis of adiponectin and the core components of the metabolic syndrome yielded four similar factors. Adiponectin loaded negatively on the 'lipids' factor in both sexes. Conclusion: The associations of adiponectin with cardiovascular risk factors showed a similar pattern in both sexes, except for uric acid. This small sex difference may not explain previous conflicting results on the association of adiponectin with cardiovascular events in men and women.

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“…In the First Nation population, obesity is more prevalent among men than women, but the prevalence of metabolic syndrome and type 2 diabetes appears to be greater for women than men, suggesting that First Nation women may be more insulin resistant than their male counterparts (6,8). Studies in Canadian Aboriginal populations have found elevated adipocytokines such as tumor necrosis factor (TNF)-␣, C-reactive protein (CRP), and leptin (9,10), whereas adiponectin levels were found to be reduced (11). In some of these studies, percent body fat determined by electric impedance was reported to be elevated.…”

mentioning

confidence: 99%

Ethnicity, Insulin Resistance, and Inflammatory Adipokines in Women at High and Low Risk for Vascular Disease

et al. 2007

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OBJECTIVE -We sought to compare the relationship between body composition, insulin resistance, and inflammatory adipokines in Aboriginal Canadian women, who are at high risk of vascular disease, with white women. RESEARCH DESIGN AND METHODS -A subgroup of the First Nations Bone HealthStudy population, consisting of 131 Aboriginal women and 132 matched white women, was utilized. Body composition was determined by whole-body dual X-ray absorptiometry, and blood analytes were measured after an overnight fast.RESULTS -After excluding individuals with diabetes, A1C, BMI, percent trunk fat, and homeostasis model assessment of insulin resistance (HOMA-IR) were greater in First Nation women compared with white women, whereas adiponectin, retinol binding protein (RBP)4, and insulin-like growth factor binding protein-1 (IGFBP-1) were lower. First Nation women had more trunk fat for any given level of total fat than white women. There were no differences in resistin, leptin, tumor necrosis factor (TNF)-␣, or C-reactive protein (CRP) levels between First Nation and white women. Insulin resistance correlated with leptin and inversely with adiponectin levels in both First Nation and white women. There were weak correlations between insulin resistance and TNF-␣, interleukin-6, and CRP, but these were not significant after correction for body fat. No correlation was found between RBP4 and insulin resistance. ANCOVA revealed a higher HOMA-IR adjusted for total body fat in First Nation women than in white women (P ϭ 0.015) but not HOMA-IR adjusted for trunk fat (P Ͼ 0.2).CONCLUSIONS -First Nation women are more insulin resistant than white women, and this is explained by trunk fat but not total fat. Despite the increased insulin resistance, inflammatory adipokines are not significantly increased in First Nation women compared with white women. Diabetes Care 30:286 -291, 2007A n increased prevalence of vascular disease in insulin-resistant states such as pre-diabetes, type 2 diabetes, and the metabolic syndrome has been long recognized (1). There is considerable debate whether insulin resistance is the primary event in atherosclerosis, with consequent activation of proinflammatory signaling pathways, or, alternatively, whether low-grade inflammation and subsequent insulin resistance accounts for the association of diabetes and vascular disease (2).Aboriginal Canadian populations, which include First Nation, Metis, and Inuit individuals (3), have an increased prevalence of atherosclerosis and cardiovascular and peripheral vascular disease (4,5). First Nations are Aboriginal individuals signatory to treaties and/or recognized by the Canadian Federal Government as a fiduciary responsibility and represent the large majority of Aboriginal individuals living in Canada (3). While type 2 diabetes is more prevalent among Canadian men than women in the general population, the reverse is true for the First Nation population (6,7). In the First Nation population, obesity is more prevalent among men than women, but the prevalence of metabolic ...

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Adiponectin in a Native Canadian Population Experiencing Rapid Epidemiological Transition

Cited by 38 publications

References 45 publications

Adiponectin and Cardiac Hypertrophy in Acromegaly

Adiponectin and Cardiac Hypertrophy in Acromegaly

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

Ethnicity, Insulin Resistance, and Inflammatory Adipokines in Women at High and Low Risk for Vascular Disease

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