Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population

Al-Daghri, Nasser M.; Al‐Attas, Omar S.; Alokail, Majed S.; Alkharfy, Khalid M.; Hussain, Tajamul; Yakout, Sobhy M.; Vinodson, Benjamin; Sabico, Shaun

doi:10.1016/j.gene.2011.11.045

Cited by 41 publications

(34 citation statements)

References 53 publications

(89 reference statements)

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“…T2DM is a complex polygenic disease resulting from complex interactions between multiple environmental and genetic factors (Permutt et al, 2005;Freeman and Cox, 2006;Liu et al, 2011;Al-Daghri et al, 2012;Gan and Yang, 2012;Gonul et al, 2012). Genetic factors play key roles in the pathogenesis of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population

Fu¹,

Sun²,

Wang³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. Two novel genetic polymorphisms (g.12375A>G and g.14367G>A) were investigated, and our data support the idea that the g.14367G>A variant significantly increased susceptibility to T2DM in homozygote comparison (AA vs GG: OR = 2.396, 95%CI = 1.682-3.413, P < 0.0001), heterozygote comparison (GA vs AA: OR = 1.322, 95%CI = 1.050-1.664, P = 0.0175), dominant model (AA/GA vs GG: OR = 1.511, 95%CI = 1.217-1.876, P = 0.0002), recessive model (AA vs GA/GG: OR = 2.093, 95%CI = 1.496-2.927, P < 0.0001), and allele contrast (A vs G: OR = 1.503, 95%CI = 1.279-1.766, P < 0.0001). The allele A of g.14367G>A

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population

Fu¹,

Sun²,

Wang³

et al. 2013

Genet. Mol. Res.

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“…We performed Galbraith plot analysis to further identify the outliers that might contribute to heterogeneity. Our results revealed two outlier studies [27,34]; the I 2 value decreased to 0.0% after omitting the two studies. The result of meta-analysis was not altered after decreasing the heterogeneity among the overall population.…”

Section: Meta-analysis Resultsmentioning

confidence: 54%

“…However, this study only assessed the genetic influence on IR using HOMA-IR under a codominant model and not the genetic influence on blood glucose. Furthermore, other studies [13,16,19,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] regarding the association between the ADIPOQ T45G polymorphism and IR have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The heterogeneity disappeared when two studies [27,34] were excluded by Galbraith plot analysis among the overall population. This finding suggested that the two previously mentioned studies [27,34] may be the source of heterogeneity. The pooled SMD did not change by omitting the two studies, indicating that our results were robust and reliable.…”

Section: Discussionmentioning

confidence: 99%

“…2). For F-insulin, we excluded two studies [27,34] that were shown as outliers in our Galbraith plot analysis, and the summary SMD in the overall population was not materially altered. We did not perform subgroup analysis for 2-h BG because of the limited number of studies ( Table 2).…”

Section: Data Extractionmentioning

confidence: 99%

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Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

et al. 2014

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InsulIn resIstance (Ir) is characterized by a decreased capacity of insulin to perform its normal physiological functions. IR is regulated by both environmental and genetic factors [1,2], and is considered as the core factor in the pathogenesis of metabolic syndrome and obesity. In recent years, numerous studies have revealed abundant information about the molecular mechanism of IR [3,4]. However, the exact pathogenesis underlying the development and progression of IR remains unclear.Adiponectin, the most abundant adipocyte-derived protein, is involved in the control of glucose, fat metabolism, and insulin sensitivity [5,6]. Adiponectindeficient mice exhibit IR and glucose intolerance [7,8], and animal models of obesity and IR show reduced plasma adiponectin levels [9,10]. Adiponectin exerts a potent insulin-sensitizing effect through its receptors AdipoR1 and AdipoR2, leading to the activation Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: A meta-analysis Results of published studies on the association of the ADIPOQ T45G polymorphism with insulin resistance (IR) and blood glucose are conflicting. In this study, we performed a meta-analysis to further investigate such an association. Articles that evaluate the effect of the T45G polymorphism on IR and blood glucose were identified from the PubMed and Embase databases. Five indices, including fasting blood glucose (FBG), fasting insulin (F-insulin), 2-h blood glucose (2-h BG), 2-h insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), were used to assess the effects of the T45G polymorphism on IR and blood glucose under a dominant model. 24 articles involving 7630 subjects were included. Twenty-two studies on FBG, 17 on F-insulin, 20 on HOMA-IR, and 3 on 2-h BG were included. No study on 2-h insulin was found. This meta-analysis revealed no significant association between the ADIPOQ T45G polymorphism and IR and blood glucose in the overall population and subgroup subjects under a dominant model, regardless of whether FBG, F-insulin, 2-h BG, or HOMA-IR was used. The present meta-analysis indicated that the mutation allele may have no function in IR development. The ADIPOQ T45G polymorphism is not associated with IR and blood glucose.

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AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta‐Analysis and Meta‐Regression

Wang

et al. 2014

Clinical Laboratory Analysis

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Background: Adiponectin (AdipoQ) is an adipose-derived plasma protein that plays an important role in hepatic lipoproteinlipid metabolism. Emerging evidence have shown that two common polymorphisms (T45 G and G276 T) in the AdipoQ gene may contribute to increasing susceptibility to nonalcoholic fatty liver disease (NAFLD); however individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association of AdipoQ T45 G (rs2241766 T>G) and G276 T (rs1501299 G>T) polymorphisms with NAFLD risk. Method: Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Bio-medicine Database (CBM), and Chinese Sci-tech Journals databases. Statistical analyses were calculated using the version 12.0 STATA software (Stata Corp, College Station, TX, USA). Odds ratios (ORs) and its corresponding 95% confidence interval (CI) were calculated. Result: Ten case-control studies were included with a total of 2,672 subjects, of these 1,117 being NAFLD patients and 1,555 being healthy controls. Our meta-analysis results revealed that the T variant of AdipoQ rs2241766 T>G polymorphism may be associated with an increased risk of NAFLD. There was also a significant association between the G variant of AdipoQ rs1501299 G>T polymorphism and an increased risk of NAFLD. Country-stratified analysis indicated that a higher AdipoQ rs2241766 T>G polymorphism was closely related with an increased risk of NAFLD in Chinese and Indian populations (all Ps < 0.05); a similar result was observed in Chinese populations between AdipoQ rs2241766 T>G polymorphism and an increased risk of NAFLD (P < 0.05). Conclusion:In conclusion, the current meta-analysis indicates that AdipoQ rs2241766 T>G and rs1501299 G>T polymorphisms may contribute to an increasing susceptibility to NAFLD. Moreover, this meta-analysis also suggests for future larger studies with stratified case-control population, and greater focus on the geneenvironment interactions regarding NAFLD susceptibility for valid studies.

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Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population

Cited by 41 publications

References 53 publications

Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population

Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta‐Analysis and Meta‐Regression

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