Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome

Xu, Xiangdong; Lai, Yerui; Yang, Gangyi; Yang, Mengliu; Li, Ling; Zhang, Qin; Liu, Hua; Wang, Cong-Yi; Zhu, Dong

doi:10.1097/md.0000000000005524

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…A study has shown that adiponectin, as the indicator of MetS in obese children, correlated with body weight and waist circumference 12 . The similar correlation using AI in regression models also supports this finding as AI correlated with BMI (β=0.177, p=0.000) and strongly correlated with HOMA IR 13 . Adiponectin level in PCOS women also correlated with IR, insulin sensitivity, BMI and adiposity.…”

Section: Discussionsupporting

confidence: 72%

“…To assess the usefulness of AI to determine IR and MetS in obese adolescents where AI = adiponectin ± (fasting blood glucose x fasting insulin) 13 .…”

Section: Objectivesmentioning

confidence: 99%

“…Adiponectin index (AI), defined as adiponectin divided with (fasting blood glucose x fasting insulin), has been used to determined insulin sensitivity and MetS in polycystic ovary syndrome (PCOS) with high sensitivity and specificity 13 .…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin index to assess metabolic syndrome and insulin resistance in obese adolescents

Widjaja,

Irawan,

Hanindita

et al. 2024

Sri Lanka J Child Health

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Background: Adiponectin level is decreased in obesity, and is suspected to be the cause of metabolic syndrome (MetS) and even linked with the onset of insulin resistance (IR). Adiponectin index (AI) has been used to determine IR and MetS in polycystic ovary syndrome (POCS).Objectives: To assess the usefulness of AI to determine IR and MetS in obese adolescents.Method: A cross sectional study was performed in obese adolescents from January to May 2020 in Sidoarjo and Surabaya Junior/High School, Indonesia.Results: AI had a weak negative correlation with body weight, waist circumference, hip circumference and body mass index. AI also correlated with triglyceride, systolic blood pressure, fasting insulin, homeostatic model assessment for IR (HOMA-IR) and high-density lipoprotein cholesterol HDL-c. Obese adolescent with MetS had bigger AI than non-MetS (0.21+ 0.18 vs. 0.13+0.09, p=0.0000). A similar phenomenon was seen in obese adolescents with IR (0.37+0.51 vs. 0.11+0.07, p=0.000). AI had a better prognostic value to determine IR than MetS, with larger area under curve (AUC), 0.890 vs. 0.606. Cut-off value to determine IR was <0.17, with sensitivity 81.3% and specificity 88.5%.Conclusions: AI is better to determine IR than MetS with a cut-off of <0.17 in obese adolescents.

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Section: Discussionsupporting

confidence: 72%

“…To assess the usefulness of AI to determine IR and MetS in obese adolescents where AI = adiponectin ± (fasting blood glucose x fasting insulin) 13 .…”

Section: Objectivesmentioning

confidence: 99%

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Adiponectin index to assess metabolic syndrome and insulin resistance in obese adolescents

Widjaja,

Irawan,

Hanindita

et al. 2024

Sri Lanka J Child Health

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“…We therefore believe that the detection of circulating CTRP5 is of great significance for screening MetS. To determine the existence of IR, the euglycemic-hyperinsulinemic clamp (EHC) is considered a “gold standard” measure of insulin sensitivity [31]. However, it is not available in a clinical setting and is costly, time consuming, and invasive and requires trained staff.…”

Section: Discussionmentioning

confidence: 99%

C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components

Jiang

Yang

Zhao

et al. 2018

International Journal of Endocrinology

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Objective C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Methods We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals. Serum CTRP5 concentrations were determined by ELISA. The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman's correlation and multiple stepwise regression analysis. Results Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. Overweight/obese individuals (BMI ≥ 25 kg/m2) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m2) in the study population (124.1 (99.12–147.37) vs. 103.9 (79.15–124.25) μg/L; P < 0.01). Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C (P < 0.05 or P < 0.01). Binary logistic regression revealed that serum CTRP5 levels were associated with MetS. In addition, serum CTRP5 levels gradually decreased with the increase in MetS components. Conclusions Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance. This trial is registered with ChiCTR-OCS-13003185.

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“…The adipose tissue is not only a main place of energy storage in organism but also active endocrine organs, which secretes a variety of bioactive molecules collectively termed as adipokines or adipocytokines [169, 170]. The most important peptide hormone produced by visceral adipose tissue is adiponectin [171], which contributes to the regulation of glucose [172] and fatty acid metabolism [173] as well as cardiovascular homeostasis [174]. Adiponectin influences, among others, on the levels of interleukin 6 (proinflammatory cytokine), tumor necrosis factor-alpha (regulator of insulin resistance), leptin (regulator of energy balance and suppressor of food intake), and angiotensinogen PAI-1 (regulator of blood pressure and fluid balance) [175].…”

Section: Training-evoked Increase In the Bdnf Level Prevents Symptmentioning

confidence: 99%

Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor—A Systematic Review

Mrówczyński¹

2019

Neural Plasticity

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This article presents a concept that wide expression of brain-derived neurotrophic factor (BDNF) and its receptors (TrkB) in the nervous tissue, evoked by regular endurance training (ET), can cause numerous motor and metabolic adaptations, which are beneficial for human health. The relationships between the training-evoked increase of endogenous BDNF and molecular and/or physiological adaptations in the nervous structures controlling both motor performance and homeostasis of the whole organism have been presented. Due to a very wide range of plastic changes that ET has exerted on various systems of the body, the improvement of motor skills and counteraction of the development of civilization diseases resulting from the posttraining increase of BDNF/TrkB levels have been discussed, as important for people, who undertake ET. Thus, this report presents the influence of endurance exercises on the (1) transformation of motoneuron properties, which are a final element of the motor pathways, (2) reduction of motor deficits evoked by Parkinson disease, and (3) prevention of the metabolic syndrome (MetS). This review suggests that the increase of posttraining levels of BDNF and its TrkB receptors causes simultaneous changes in the activity of the spinal cord, the substantia nigra, and the hypothalamic nuclei neurons, which are responsible for the alteration of the functional properties of motoneurons innervating the skeletal muscles, for the enhancement of dopamine release in the brain, and for the modulation of hormone levels involved in regulating the metabolic processes, responsively. Finally, training-evoked increase of the BDNF/TrkB leads to a change in a manner of regulation of skeletal muscles, causes a reduction of motor deficits observed in the Parkinson disease, and lowers weight, glucose level, and blood pressure, which accompany the MetS. Therefore, BDNF seems to be the molecular factor of pleiotropic activity, important in the modulation processes, underlying adaptations, which result from ET.

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Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome

Cited by 7 publications

References 17 publications

Adiponectin index to assess metabolic syndrome and insulin resistance in obese adolescents

Adiponectin index to assess metabolic syndrome and insulin resistance in obese adolescents

C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components

Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor—A Systematic Review

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