Adiponectin does not improve the prediction of insulin need in pregnant women with gestational diabetes mellitus

Paganoti, Cristiane de Freitas; Costa, Rafaela Alkmin da; Oliveira, Ana Maria da Silva Sousa; Hoshida, Mara Sandra; Francisco, Rossana Pulcineli Vieira

doi:10.1016/j.endmts.2021.100095

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…In pregnancies with GDM, insulin resistance was associated with HOMA%S, serum levels of adiponectin, leptin and maternal weight gain (8). In GDM-N, maternal adiponectin levels were correlated with OGTT 0-h (r=-0.57; P<0.01), OGTT 1-h (r=-0.42; P<0.05) and AST (r=0.43; P<0.05).…”

Section: Correlation Between Clinical and Paraclinical Characteristic...mentioning

confidence: 92%

“…It is this lack of response that stimulates the pancreas to secrete more insulin (7). Other factors involved in the development of IR during pregnancy are adipocyte-derived hormones, such as adiponectin and leptin (8). Adiponectin regulates insulin action and glucose homeostasis, the serum levels of which decrease during pregnancy (8).…”

Section: Introductionmentioning

confidence: 99%

“…Other factors involved in the development of IR during pregnancy are adipocyte-derived hormones, such as adiponectin and leptin (8). Adiponectin regulates insulin action and glucose homeostasis, the serum levels of which decrease during pregnancy (8). During the third trimester of pregnancy, when the severity of maternal IR is at its highest, circulating adiponectin reaches its lowest level (9).…”

Section: Introductionmentioning

confidence: 99%

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New born macrosomia in gestational diabetes mellitus

Bernea¹,

Uyy²,

Mihai³

et al. 2022

Exp Ther Med

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Gestational diabetes mellitus (GDM) is a metabolic complication of pregnancy. The pathogenesis of GDM is considered to involve β-cell dysfunction and insulin resistance (IR). GDM is associated with a significant risk of macrosomia in addition to a high probability of metabolic complications for the offspring. The precise mechanism underlying GDM remains unclear. The aim of the present study was to analyse the factors associated with insulin resistance and β-cell dysfunction involved in the pathophysiology of GDM complicated with macrosomia compared with GDM without macrosomia. In addition, another aim of the present study was to assess the relationship between GDM complicated with macrosomia and anthropometric, clinical and paraclinical parameters. The following group of patients were recruited as part of a case-control study: Patients with GDM without macrosomia, patients with GDM complicated with macrosomia and healthy gestational controls. Blood samples were collected at the third trimester of pregnancy and tested for adiponectin, leptin, insulin, proinsulin and C-peptide. Homeostatic model assessment-IR (HOMA-IR), steady state β-cell function (HOMA%B), insulin sensitivity (HOMA%S) and body mass index (BMI) were also calculated. All patients diagnosed with GDM showed an impairment in HOMA%B and a decrease in C-peptide maternal serum concentration. Additionally, diabetic status leading to the birth of offspring with macrosomia did not induce changes in the maternal serum levels of insulin, proinsulin, adiponectin or leptin, which was also the case in patients with GDM but not macrosomia. HOMA%B presented a stronger positive correlation with pre-pregnancy BMI and maternal weight gain, and a stronger negative correlation with adiponectin. Furthermore, HOMA%S in this group exhibited strong positive correlations with maternal serum levels of high-density lipoprotein cholesterol (HDL) and aspartate aminotransferase, and a strong negative correlation with pre-pregnancy BMI. In the same patients, HOMA-IR was also found to have a high negative correlation with HDL levels, and highly positive correlations with gestational age and triglyceride levels. In conclusion, the present study suggests that the different correlations among the factors involved in the pathogenesis of GDM may explain the evolution of GDM pregnancy to macrosomia.

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Section: Correlation Between Clinical and Paraclinical Characteristic...mentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

New born macrosomia in gestational diabetes mellitus

Bernea¹,

Uyy²,

Mihai³

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Gestational diabetes mellitus (GDM) is described as any level of glucose intolerance that occurs during pregnancy resulting in hyperglycemia [1]. As one of the most frequent complications in pregnancy, it is now considered a primary global concern as it has repercussions for both the mother and the baby [2]. Pre-term labor, hypertension, birth trauma, cesarean section, congenital abnormalities, high birth weight, stillbirth, growth limitation, admission to special neonatal care, and increased mortality are some of the maternal and fetal consequences of GDM [3,4,5].…”

Section: Introductionmentioning

confidence: 99%