Adiponectin Concentrations in Type 2 Diabetic Patients with or without Metabolic Syndrome

Abstract

Background: Adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism. The aim of this study was to evaluate the relationship between serum adiponectin concentrations and metabolic syndrome (MS) in patients with type 2 diabetes mellitus. Methods: This study included 127 type 2 diabetic patients (males 63, females 64). The subjects were divided into two groups as with or without metabolic syndrome (MS(+) or MS(-)). The MS was diagnosed by International Diabetes Federation. Serum adiponectin, leptin, fasting plasma insulin, glucose, glycated hemoglobin, lipid profile, white blood corpuscle (WBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and C-reactive protein (CRP) were examined. Results: Serum adiponectin concentrations were significantly lower in MS(+) than MS(-) (4.8 ± 2.4 μg/mL vs 7.6 ± 5.8 μg/mL, 7.6 ± 3.7 μg/mL vs 11.5 ± 7.2 μg/mL, P < 0.05 in males and females). After adjustment for age and body mass index (BMI), in MS (+), the serum levels of adiponectin correlated positively with high density lipoprotein -cholesterol (HDL-C) and negatively with height, body weight, ALT and CRP. In MS(-), the serum levels of adiponectin correlated positively with HDL-C and negatively with diastolic blood pressure (DBP), triglyceride and CRP. By multiple regression analysis, no parameters were independently correlated with serum adiponectin concentrations in MS(+), while DBP and HDL-C were independently related to serum adiponectin concentrations in MS(-). Conclusion: Serum adiponectin concentrations were lower in type 2 diabetic patients with MS than without MS. There were no significant parameters related to decrease serum adiponectin concentrations in MS. But further study is needed to confirm this result.

Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications

“…A relationship between circulating adiponectin level and metabolic conditions such as insulin resistance, obesity, and diabetes mellitus has been demonstrated in previous studies [2-4]. Circulating adiponectin concentration has been shown to be significantly correlated with microalbuminuria and overt nephropathy in type 1 diabetic patients [5,6].…”