Adiponectin, body mass index and hepatic steatosis are independently associated with IGF-I status in obese non-diabetic women

Sîrbu, Anca; Gologan, S.; Arbănaş, Tudor; Copăescu, C; Martin, Sorina; Albu, Alice; Barbu, Carmen; Pirvulescu, Iuliana; Fica, Simona

doi:10.1016/j.ghir.2012.10.001

Cited by 23 publications

(24 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a positive correlation between the IGF-1 z score and adiponectin was observed among obese nondiabetic women (19). This association remained significant even after adjustment for age, BMI, insulin sensitivity, and chronic inflammation indices (19). In agreement with our results, no consistent association between IGF-1 and adiponectin in healthy elderly male Lebanese (36) and among postmenopausal women (21) was reported.…”

Section: Discussionsupporting

confidence: 66%

“…The results of recent studies show sufficient evidence indicating that omentin-1 may be a good adipocytokine (19,20). Thus, omentin-1 may have a positive correlation with the IGF-1 level.…”

Section: Discussionmentioning

confidence: 94%

“…The authors suggested IGF-1 might suppress serum adiponectin levels (20). However, a positive correlation between the IGF-1 z score and adiponectin was observed among obese nondiabetic women (19). This association remained significant even after adjustment for age, BMI, insulin sensitivity, and chronic inflammation indices (19).…”

Section: Discussionmentioning

confidence: 97%

“…In agreement with our results, no consistent association between IGF-1 and adiponectin in healthy elderly male Lebanese (36) and among postmenopausal women (21) was reported. It seems that the conflicting results may arise because the studies were conducted in different categories of patients and serum levels of IGF-1 and this adipocytokine may be influenced by the accompanying pathological conditions (19).…”

Section: Discussionmentioning

confidence: 99%

“…Positive correlation in obese nondiabetic women (19), negative association in type 2 diabetes mellitus (20), and no consistent association in postmenopausal women (21) were found between adiponectin and IGF-1 levels. The GH/ IGF-1 cascade in relation to visfatin levels was investigated in patients with HIV (22), growth hormone deficiency (23), active acromegaly (24), retinopathy of prematurity (25), in relation to prenatal growth (26), and in human articular chondrocytes (27).…”

Section: Introductionmentioning

confidence: 90%

See 4 more Smart Citations

The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

et al. 2017

View full text Add to dashboard Cite

The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlations were found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausal women beyond metabolic syndrome, type 2 diabetes, bone formation markers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects. ARTICLE HISTORY

show abstract

Section: Discussionsupporting

confidence: 66%

“…The results of recent studies show sufficient evidence indicating that omentin-1 may be a good adipocytokine (19,20). Thus, omentin-1 may have a positive correlation with the IGF-1 level.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 3 more Smart Citations

The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

et al. 2017

View full text Add to dashboard Cite

show abstract

Analysis of the adiponectin paradox in healthy older people

Walowski

Enderlé

Braun

et al. 2022

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background It remains unknown why adiponectin levels are associated with poor physical functioning, skeletal muscle mass and increased mortality in older populations. Methods In 190 healthy adults (59-86 years, BMI 17-37 kg/m 2 , 56.8% female), whole body skeletal muscle mass (normalized by height, SMI, kg/m 2 ), muscle and liver fat were determined by magnetic resonance imaging. Bone mineral content (BMC) and density (BMD) were assessed by dual X-ray absorptiometry (n = 135). Levels of insulin-like growth factor 1 (IGF-1), insulin, inflammation markers, leptin and fibroblast growth factor 21 were measured as potential determinants of the relationship between adiponectin and body composition. Results Higher adiponectin levels were associated with a lower SMI (r = À0.23, P < 0.01), BMC (r = À0.17, P < 0.05) and liver fat (r = À0.20, P < 0.05) in the total population and with higher muscle fat in women (r = 0.27, P < 0.01). By contrast, IGF-1 showed positive correlations with SMI (r = 0.33), BMD (r = 0.37) and BMC (r = 0.33) (all P < 0.01) and a negative correlation with muscle fat (r = À0.17, P < 0.05). IGF-1 was negatively associated with age (r = À0.21, P < 0.01) and with adiponectin (r = À0.15, P < 0.05). Stepwise regression analyses revealed that IGF-1, insulin and leptin explained 18% of the variance in SMI, and IGF-1, leptin and age explained 16% of the variance in BMC, whereas adiponectin did not contribute to these models. Conclusions Associations between higher adiponectin levels and lower muscle or bone mass in healthy older adults may be explained by a decrease in IGF-1 with increasing adiponectin levels.

show abstract

The Value of Serologic Markers/Scores in the Assessment of Nonalcoholic Fatty Liver Disease

Preda

Manuc

Diculescu

2023

Essentials of Non-Alcoholic Fatty Liver Disease

View full text Add to dashboard Cite

Adiponectin, body mass index and hepatic steatosis are independently associated with IGF-I status in obese non-diabetic women

Cited by 23 publications

References 42 publications

The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

Analysis of the adiponectin paradox in healthy older people

The Value of Serologic Markers/Scores in the Assessment of Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About