Adiponectin as a growth inhibitor in prostate cancer cells

Bub, Jeffrey D.; Miyazaki, Toshiaki; Iwamoto, Yoshiki

doi:10.1016/j.bbrc.2005.12.103

Cited by 186 publications

(142 citation statements)

References 55 publications

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“…The mechanisms are not clear yet and require further investigation. However, recent studies have provided evidence that adipose tissue can produce many cytokines (adipokines), such as leptin and adiponectin, which can potently affect the biological behavior of malignant cells [41][42][43][44][45][46][47][48][49][50]. Our data support the hypothesis that these adipose tissue-derived factors are differently associated with the caricinogenesis or progression of GC of each histological type.…”

Section: Discussionsupporting

confidence: 83%

“…Recent studies have demonstrated that adipocytes produce a variety of secretory peptides, named adipokines [39,40]. More recently, some adipokines, such as leptin and adiponectin, have been shown to critically regulate the biological behavior of malignant cells [41][42][43][44][45][46][47][48][49][50], raising the possibility that adipocytes may have positive roles in the development of malignant diseases through the secretion of adipokines in an endocrine or intracrine manner. In addition, it has been suggested that the biochemical characteristics of visceral and subcutaneous adipose tissues are somewhat different [51,52].…”

Section: Introductionmentioning

confidence: 99%

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Early gastric cancer shows different associations with adipose tissue volume depending on histological type

et al. 2008

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Early gastric cancer shows different associations with adipose tissue volume depending on histological type

et al. 2008

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“…These clinical observations raise the possibility that adiponectin itself might directly act as an inhibitory factor on tumor growth. Consistent with this hypothesis, several cellular studies find that adiponectin can elicit anti-proliferative effects in breast cancer and prostate cancer cells (Bub et al 2006, Dieudonne et al 2006, Korner et al 2007, Wang et al 2006.…”

Section: Introductionmentioning

confidence: 59%

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95–2

Li¹,

Gasser²,

Zhao³

et al. 2007

Endocr Relat Cancer

112

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Obesity is one of the well-established risk factors for endometrial cancer. Recent clinical studies have demonstrated that circulating adiponectin concentrations are inversely correlated with the incidence of endometrial carcinoma. Such epidemiological findings are consistent with the paradoxical observations that adiponectin levels are reduced in obesity. This study investigated the direct effects of adiponectin on two endometrial carcinoma cell lines, HEC-1-A and RL95-2. These cell lines express both variants of adiponectin receptors, adipo-R1 and adipo-R2. Adiponectin treatment leads to suppression of cell proliferation in both cell types, which is primarily due to the significant increase of cell populations at G 1 /G 0 -phase and to the induction of apoptosis. The inhibition of growth in these two cell lines appears to be mediated by different signaling pathways. Although adiponectin treatment markedly increases the phosphorylation (Thr172) of AMP-activated protein kinase a in both HEC-1-A and RL95-2 within 30 min, prolonged exposure (48 h) leads to inactivation of Akt as well as reduction of cyclin D1 protein expression in HEC-1-A cells. In contrast, similar treatment of RL95-2 cells with adiponectin, while having no effects on Akt activity and cyclin D1 expression, causes a decrease in cyclin E2 expression and the activity of mitogen-activated kinase (p42/44). We conclude that adiponectin exerts direct anti-proliferative effects on HEC-1-A and RL95-2 cells by inducing cell cycle arrest and apoptosis. Depending on the genotypes of the endometrial cancer cells, the inhibitory effects of adiponectin are associated with the reduction of different pro-growth regulators of cell cycle and signaling proteins. Our study thus provides a cellular mechanism underlying the linkages between endometrial cancer and obesity.

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“…Furthermore, studies on breast and prostate cancer cell lines have shown that adiponectin may control cancer cell numbers by inhibiting cell proliferation and inducing apoptosis (Bub et al 2006;Dieudonne et al 2006), which suggests that adiponectin may suppress cancer cell development.…”

mentioning

confidence: 99%

Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

Abdul‐Ghafar

Park

et al. 2013

Tohoku J. Exp. Med.

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Lung cancer is a major cause of cancer-related death worldwide. It is believed that obesity-related malignancies such as breast, endometrial, colorectal, and kidney carcinomas have lower plasma level and/ or tissue expression of adiponectin receptors. However, the association between adiponectin receptors and lung cancer, a non obesity-related malignancy, is still unknown. We evaluated the tissue expression of adiponectin receptor (AdipoR) 1 and AdipoR2 in 83 cases of non-small cell lung carcinoma (NSCLC) and matched non-neoplastic lung tissues by immunohistochemistry and real-time polymerase chain reaction (PCR). Clinicopathological data, including smoking history, smoker's bronchiolitis, emphysema, lymph node metastasis, and T-stage were collected and evaluated. Expression of immunohistochemically stained AdipoR1 and AdipoR2 was observed in all samples of non-neoplastic lung tissues. Both receptors showed higher mRNA expression in non-neoplastic than neoplastic tissues ( p < 0.05). In NSCLC tissues, AdipoR1 immunohistochemical expression was not observed in most of patients with squamous cell carcinoma and current smoking history (31/42, p = 0.04 and 25/29, p = 0.003, respectively). Additionally, AdipoR1 mRNA expression was significantly lower in patients with lymph node metastasis ( p = 0.05). Meanwhile, AdipoR2 immunohistochemical stain expression was inversely correlated with T-stage ( p = 0.05) and AdipoR2 mRNA expression was significantly lower in patients with smoker's bronchiolitis ( p = 0.01) and emphysema ( p = 0.03). Patients with expression of AdipoR1 had longer overall survival. AdipoR2 expression was not correlated with patients' survival. In conclusion, we suggest that expression of AdipoR1 is indicative of favorable prognosis and may be used as prognostic marker in NSCLC.

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Adiponectin as a growth inhibitor in prostate cancer cells

Cited by 186 publications

References 55 publications

Early gastric cancer shows different associations with adipose tissue volume depending on histological type

Early gastric cancer shows different associations with adipose tissue volume depending on histological type

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95–2

Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

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