Adiponectin and Resistin in Human Cerebrospinal Fluid and Expression of Adiponectin Receptors in the Human Hypothalamus

Kos, Katarina; Harte, Alison; Silva, Nancy F. da; Tonchev, Anton B.; Chaldakov, Georgi; James, Sean; Snead, David; Hoggart, Barbara; O’Hare, J. Paul; McTernan, P. G.; Kumar, Sudhesh

doi:10.1210/jc.2006-1841

Cited by 183 publications

(151 citation statements)

References 34 publications

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“…While elevated adiponectin levels were present in serum and cerebrospinal fluid during fasting state in mice, these levels were normalized after refeeding, suggesting that adiponectin might influence food intake via central mechanism in the brain (Kubota et al 2007). One may argue whether similar central effects exist in humans (Pan et al 2006;Kos et al 2006). Consistent with potential central effects, human adiponectin levels were also shown to be altered in eating disorders such as anorexia nervosa, binge eating disorder and bulimia nervosa (reviewed in, e.g., Bou Khalil and El Hachem 2014).…”

Section: Introductionmentioning

confidence: 91%

Role of genetic variants in ADIPOQ in human eating behavior

et al. 2014

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The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eating. Here, we tested the hypothesis that (1) adiponectin serum levels correlate with human eating behavior factors and (2) that genetic variants of the ADIPOQ locus influence both serum levels and eating behavior. We analyzed 11 SNPs within ADIPOQ and in the 5 0 UTR and measured serum adiponectin levels in 1,036 individuals from the German Sorbs population. The German version of the three-factor eating questionnaire (FEV) was completed by 548 Sorbs. For replication purposes, we included an independent replication cohort from Germany (N = 350). In the Sorbs, we observed positive correlations of restraint with adiponectin serum levels (P = 0.001; r = 0.148) which, however, did not withstand adjustment for covariates (P = 0.083; r = 0.077). In addition, four SNPs were nominally associated with serum adiponectin levels (all P \ 0.05). Of these, two variants (rs3774261; rs1501229, all P \ 0.05) were also related to disinhibition. Furthermore, three variants were exclusively associated with hunger (rs2036373, P = 0.049) and disinhibition (rs822396; rs864265, all P \ 0.05). However, none of these associations withstood Bonferroni corrections for multiple testing (all P [ 9.3 9 10 -4 ). In our replication cohort, we observed similar effect directions at rs1501229 for disinhibition and hunger. A meta-analysis resulted in nominal statistical significance P = 0.036 (Z score 2.086) and P = 0.017 (Z score 2.366), respectively. Given the observed relationship of the SNPs with adiponectin levels and eating behavior, our data support a potential role of adiponectin in human eating behavior. Whether the relationship with eating behavior is mediated by the effects of circulating adiponectin warrants further investigations.

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Section: Introductionmentioning

confidence: 91%

Role of genetic variants in ADIPOQ in human eating behavior

et al. 2014

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“…To our knowledge, a sexual dimorphism has been described in the levels of circulating plasma adiponectin, with males having lower adiponectin levels than females (Arita et al 1999). However, adiponectin levels in human cerebrospinal fluid (CFS) showed no gender difference (Kos et al 2007). Expression of resistin has been reported in the hypothalamus of rodents (Morash et al 2002).…”

Section: Adiponectin and Resistin Expression And Action At Hypothalammentioning

confidence: 99%

“…Expression of resistin has been reported in the hypothalamus of rodents (Morash et al 2002). Resistin was identified in the human CSF with levels 100-fold lower than that in the serum (Kos et al 2007). However, its role in GnRH neurons remains to be determined.…”

Section: Adiponectin and Resistin Expression And Action At Hypothalammentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

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Adipokines, including adiponectin and resistin, are cytokines produced mainly by the adipose tissue. They play a significant role in metabolic functions that regulate the insulin sensitivity and inflammation. Alterations in adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissues, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species. Thus, these adipokines could be metabolic signals that partially explain infertility related to obesity, such as polycystic ovary syndrome (PCOS). Species and gender differences in plasma levels, tissue or cell distribution and hormonal regulation have been reported for resistin and adiponectin. Furthermore, until now, it has been unclear whether adiponectin and resistin act directly or indirectly on the hypothalamo-pituitary-gonadal axis. The objective of this review was to summarise the latest findings and particularly the species and gender differences of adiponectin and resistin on female and male reproduction known to date, based on the hypothalamo-pituitary-gonadal axis.Reproduction (2017) 153 R215-R226

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“…Because resistin is present in the CSF (Kos et al, 2007) and is expressed locally in the hypothalamus (Wilkinson et al, 2005), it is possible the change in insulin sensitivity involves hormonal as well as paracrine mechanisms. Thus, we determined whether centrally administered resistin was still capable of regulating glucose fluxes in the absence of endogenous resistin expression.…”

Section: Central Resistin Impairs Insulin Sensitivitymentioning

confidence: 99%