Adiponectin and pro‐inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus

Abstract

Aims/IntroductionAdipose tissue‐derived hormones are associated with metabolic disorders including type 2 diabetes mellitus. The present study investigated the levels of adiponectin and pro‐inflammatory cytokines including tumor necrosis factor‐α (TNF‐α), interleukin‐1 beta (IL‐1β) and IL‐10 in Vietnamese patients with type 2 diabetes mellitus, and their correlations with clinical parameters of overweight and type 2 diabetes mellitus.Materials and MethodsBased on body mass index, 73 patients with type 2 diabetes mellitus were categorized either as overweight or non‐overweight. As healthy controls, 57 overweight and non‐overweight individuals without type 2 diabetes mellitus were included. The adiponectin, TNF‐α, IL‐1β and IL‐10 levels were measured in the sera samples in all study participants by enzyme‐linked immunosorbent assay and were correlated with clinical parameters.ResultsThe adiponectin levels were lower in patients with type 2 diabetes mellitus (2.5 ± 1.5 μg/mL) compared with controls (16 ± 18.6 μg/mL; P < 0.0001), and were decreased in overweight individuals compared with those who were not overweight. The TNF‐α and IL‐1β levels were increased, whereas the IL‐10 levels were decreased in patients with type 2 diabetes mellitus and in overweight controls compared with non‐overweight controls (P < 0.0001). The adiponectin levels were correlated with the TNF‐α, IL‐1β, IL‐10 levels, and the clinical parameters of overweight and type 2 diabetes mellitus. The quantitative insulin sensitivity check index and homeostasis model assessment insulin resistance indexes were correlated with the relative ratios of adiponectin/TNF‐α, adiponectin/IL‐1β, adiponectin/IL‐10, TNF‐α/IL‐10 and IL‐1β/IL‐10.ConclusionsAdiponectin and pro‐inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight‐related type 2 diabetes mellitus.

Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway

“…In addition, the associations between insulin resistance, low-grade inflammation and type-I diabetes mellitus have been investigated in a previous study (42). Changes in inflammatory/necrosis biomarkers following exercise treatment have been analyzed in the progression of diabetes mellitus (43,44). However, to the best of our knowledge, the molecular mechanisms involved in diabetes mellitus have not been clearly elaborated during previous studies.…”

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

“…HMW treatment improved glucose homeostasis and reduced inflammation by regulating APPL1-AMPK-GLUT4 signaling in 3T3-L1 adipocytes subjected to glucolipotoxicity [132]. In addition, some studies indicated that HMW has a negative relationship with inflammatory markers in type 2 diabetic patients [133][134][135] and obese people [136].…”

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

“…Adiponectin and leptin, the most prevalent adipo-cytokines, produced in adipose tissue, play critical metabolic and anti-inflammatory roles through adipose tissue crosstalk. [81][82][83] Low adiponectin and high leptin correlate with many metabolic diseases including T2D, MS, and obesity [82][83][84][85][86][87] and are considered as predictive clinical markers. While some studies showed HIIT does not affect adiponectin 53,56,88 or leptin, 58,89 others report increased adiponectin 41,45,55,67 and decreased leptin.…”