Adiponectin and leptin gene polymorphisms in women with gestational diabetes mellitus

Abstract

The results of our study suggest an association between adiponectin gene rs266729 as well as leptin gene rs2167270 polymorphisms and GDM.

Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes

“…In previous studies, the association between polymorphisms and gestational diabetes was studied in three models: additive (number of variant alleles = 0, 1, or 2 for each subject), dominant (variant homozygotes and heterozygotes vs. wildtype homozygotes) and recessive (variant homozygotes vs. heterozygotes and wildtype homozygotes) [10][11][12][13][14][15][16][17]. The best fit was observed for the additive model.…”

“…Therefore the additive model of genotype-phenotype association was selected for all polymorphisms in this study as it was the simplest and the most appropriate. All polymorphisms that were significantly associated with GDM in univariate analyses in previous studies [10][11][12][13][14][15][16][17] were included as independent variables in the current study.…”

“…Numerous studies indicate a similar background to GDM and type 2 diabetes, therefore genetic determinants of type 2 diabetes were also investigated in GDM. Previous studies examined genetic polymorphisms in carbohydrate and lipid metab-olism genes in women with GDM [10][11][12][13][14][15][16][17]. These genetic polymorphisms were also associated with an increased risk of type 2 diabetes.…”

“…Genotypes were assigned using all data from the study simultaneously. Details of genotyping methods are described in previous papers [10][11][12][13][14][15][16][17].…”

“…Therefore genetic variants associated with type 2 diabetes may also be associated with an increased risk of GDM [9]. Previous studies have examined the associations between several genetic polymorphisms involved in carbohydrate and lipid metabolism [i. e., PTGS2 (COX2) rs6681231, FADS1 rs174550, HNF1B rs4430796, ADIPOQ rs266729, IL18 rs187238, CCL2 rs1024611, HHEX rs5015480 and CDKN2A/2B rs10811661] and GDM [10][11][12][13][14][15][16][17]. Some of these polymorphisms were associated with an increased risk of GDM development or with clinical parameters in pregnant women (i. e., BMI before pregnancy, BMI at birth, weight increase during pregnancy, BMI increase during pregnancy, HbA1c, daily insulin requirement, and duration of labour) or new-born babies (body mass at birth and APGAR score).…”