Adiponectin and its receptors are involved in hypertensive vascular injury

Guo, Ruimin; Han, Min Su; Shi, Juan; Li, Jun; Sun, Yiyuan

doi:10.3892/mmr.2017.7878

Cited by 18 publications

(19 citation statements)

References 39 publications

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“…Adiponectin is secreted from adipose tissue, and endogenous adiponectin exerts protective effects against hypertensive vascular injury ( 23 ). Previous studies reported that the adiponectin concentration was lower in some cardiovascular diseases ( 24 ), and was reduced in mice subjected to CLP ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

Hou

Wang

Lang

et al. 2018

Braz J Med Biol Res

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Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protective effects of adiponectin treatment on endothelial cells and its mechanism. Male Wistar rats underwent cecal ligation and puncture (CLP) before being treated with adiponectin (72 and 120 μg/kg). The levels of malondialdehyde (MDA) in plasma, histological structure, and apoptosis of endothelial cells were evaluated. In vitro, human umbilical vein endothelial cells (HUVECs) were treated with adiponectin at 10 and 20 μg/mL for 24 h after stimulation by lipopolysaccharide (LPS). The levels of reactive oxygen species (ROS), ultrastructure, rate of apoptosis, the expression of inositol-requiring enzyme 1α (IRE1α) protein, and its downstream molecules (78 kDa glucose-regulated protein (GRP78), C/EBP homologous protein (CHOP), and caspase-12) were detected. The results showed that the levels of MDA and ROS induced by CLP or LPS stimulation were increased. Furthermore, endothelial cell apoptosis was increased under sepsis. The IRE1α pathway was initiated, as evidenced by activated IRE1α, increased GRP78, and up-regulated CHOP and caspase-12 in HUVECs. Following treatment with adiponectin, the number of apoptotic endothelial cells was markedly decreased. These findings demonstrated that treatment with adiponectin decreased apoptosis of endothelial cells caused by sepsis by attenuating the ER stress IRE1α pathway activated by oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

Hou

Wang

Lang

et al. 2018

Braz J Med Biol Res

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“…A growing number of studies have reported that adiponectin exerts multiple biological effects in different tissues or organs by binding to their receptors [156]. Adiponectin is closely related to the cardiovascular circulatory system [158,159], which is regulated by RAS. Some researches showed that Ang(1-7) supplement significantly increases the levels of adiponectin [28,160], not only in circulation but also in the myocardial [161].…”

Section: Adiponectinmentioning

confidence: 99%

AMPK: a balancer of the renin–angiotensin system

Liu

et al. 2019

Bioscience Reports

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The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy sensor, has also been discovered to be involved in these diseases and cellular pathways. This would imply a connection between the RAS and AMPK. Therefore, this review serves to draw attention to the cross-talk between RAS and AMPK, then summering the most recent literature which highlights AMPK as a point of balance between physiological and pathological functions of the RAS.

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“…Based on the literature, it can be assumed that the levels of adipocytokine mRNA in the AT are not always a complete re ection of their concentration [22]. In this study, PVAT adipocytes of patients with CAD were characterized by the highest level of adiponectin gene expression, yet the lowest concentration in the supernatant compared to adipocyte cultures of other locations.…”

Section: Discussionmentioning

confidence: 81%

Expression of adipocytokine genes and their content in various adipose tissue sites in patients with heart diseases

Груздева¹,

Dyleva

Белик

et al. 2020

Preprint

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Background Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest owing to potential effects on the myocardium and blood vessels. Objective To assess expression and secretion of adipocytokine genes in adipose tissue in patients coronary artery disease (CAD) and patients with aortic or mitral valve replacement. Methods The study included 84 patients with CAD and 50 patients with aortic or mitral valve replacement. Adipocytes were isolated from subcutaneous (SAT), epicardial (EAT), and perivascular AT (PVAT) samples. Isolated adipocytes were cultured for 24 h after which, gene expression and secretion levels of selected adipokines and cytokines in the culture medium were determined. Results The study parameters differed depending on the adipose tissue location. EAT adipocytes in CAD patients were characterized by a pronounced imbalance in the adipokine system. EAT had the lowest adiponectin gene expression and secretion, regardless of nosology and high expression levels of the leptin gene, its receptor, and interleukin-6 (IL-6) were detected. High leptin and IL-6 levels resulted in increased pro-inflammatory activity, as observed in both EAT and PVAT adipocytes, especially in individuals with coronary artery disease. Conclusion The "protective" potential of adipose tissue depends on its location.

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Adiponectin and its receptors are involved in hypertensive vascular injury

Cited by 18 publications

References 39 publications

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

AMPK: a balancer of the renin–angiotensin system

Expression of adipocytokine genes and their content in various adipose tissue sites in patients with heart diseases

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