Adiponectin and Glycemic Profiles in Type 2 Diabetes Patients on Eicosapentaenoic Acid with or without Vitamin E

Abstract

Background. Secreting different adipocytokines, adipose tissue plays an important role in health and disease. Upon omega-3 consumption, changes in the secretion of adipose tissue and its effects on glycemic profile are a controversial subject at the present time.Objectives. We evaluated the effects of eicosapentaenoic acid (EPA) alone and in combination with vitamin E on adiponectin and serum glycemic indices in type II Diabetes patients.Design. This double-blind clinical trial divided all patients randomly into four balanced permuted blocks of EPA, Vitamin E, EPA and vitamin E and placebo (Corn oil).Subjects and Methods. 127 patients with type II diabetes living in Kashan in 2008, 35-50 years old, and 25≤BMI ≤30 were enrolled. ELISA, Glucose Oxidase, spectrophotometry, and Radioimmunoassay methods were used for measurement of serum adiponectin, Fasting Blood Glucose (FBG), HbA1C, and Insulin, respectively.Results. Serum adiponectin increased significantly after EPA consumption in EPA and EPA+E groups. Moreover, FBG, HbA1c, serum insulin and Homeostasis Model HOMA-IR decreased significantly after EPA consumption in the two previously mentioned groups.Conclusions. This study showed that EPA supplementation affects the secretion of adipose tissue, improves the FBS as well as HbA1c values and significantly decreases fasting serum insulin and insulin resistance.

Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…After applying all the selection criteria, 15 studies were included in the systematic review [ 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 ]. These studies reported the following outcomes: plasminogen-activator inhibitor 1 (PAI-1), adiponectin, leptin, resistin, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6).…”

“…These studies reported the following outcomes: plasminogen-activator inhibitor 1 (PAI-1), adiponectin, leptin, resistin, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6). One study [ 42 ] had a cross-over design, and could not be included in the quantitative synthesis (meta-analysis) in Review Manager; hence, 14 studies with parallel design were included in the meta-analysis [ 30 31 32 33 34 35 36 37 38 39 40 41 43 44 ]. Fig.…”

“…Interventions in most studies consisted of omega-3 supplementation alone, in two studies [ 33 44 ] intended weight loss was a part of the intervention. Most studies used both EPA and DHA in the intervention, one study [ 30 ] used only EPA, and in one study EPA and DHA [ 38 ] were two different treatment arms, so that effect sizes were pooled separately.…”

Adiponectin Correlation with Bioclinical Benefits of Using Natural Therapeutic Factors in Knee Osteoarthritis

“…The two groups contained 23 patients each and were considered statistically similar in terms of demographic features and of associated comorbidities, such as metabolic syndrome and diabetes which might have had an impact over adiponectin values (18).…”

Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials

“…Some studies showed that vitamin E supplementation improves glycemic indices and insulin resistance in patients with T2DM from Western and Asian countries [10][11][12][13], while other studies from these regions did not report such a significant effect on patients with diabetic nephropathy [14][15][16] and T2DM patients [17][18][19]. In contrast, some studies indicated a significant increase in the blood glucose level following vitamin E supplementation among Asian patients with T2DM [20,21]. In a meta-analysis of RCTs in 2014, Xu et al reported that vitamin E supplementation did not result in significant benefits in glycemic control, as measured by glycated hemoglobin (HbA1c), and fasting insulin, among patients with T2DM [22].…”