Adiponectin and Endometrial Cancer: A Systematic Review and Meta-Analysis

Abstract

Objective: This study evaluates the association between serum adiponectin concentrations and the risk of endometrial cancer through a comprehensive meta-analysis of currently available clinical data. Methods: PubMed, Embase, the Chinese Biomedical Literature Database and the Science Citation Index (ISI Web of Science) were searched for studies that examined the association between blood adiponectin concentrations and the risk of endometrial cancer. Data from studies that met the inclusion criteria were systematically reviewed, and pooled analyses were performed according to the guidelines of Meta-Analysis of Observational Studies in Epidemiology and PRIMSA. Results: Eight case-control studies (including 1257 endometrial cancer patients and 2008 controls) and four nested case-control studies (including 659 endometrial cancer patients and 1398 controls) were included. We found that serum adiponectin level was inversely correlated with the risk of endometrial cancer development after pooling the case-control studies (OR = 0.50, 95% CI: 0.39-0.60; P < 0.001). However, meta-analysis of nested case-control studies thus far did not support a broad linkage between serum adiponectin level and endometrial cancer, although a correlation may exist in the subgroup of postmenopausal women (OR=0.81, 95%CI: 0.65-1.00; P=0.060), particularly in postmenopausal women without current hormone replacement therapy (OR = 0.62, 95% CI: 0.44-0.86; P = 0.004). Conclusions: Meta-analysis of currently available clinical evidence supports the association between high serum adiponectin concentration and reduced risk of endometrial cancer development, particularly in the group of postmenopausal women without current hormone replacement therapy. However, additional studies with prospective design are required to fully support this linkage.

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway

“…For example, a report suggested a role for the lncRNA TK1 0605 (AK0 9380) in oligodendrocyte lineage commitment [36]. In the CNC network, TK1 0605 was co-expressed with Map6d1, a member of the STOP family that is responsible for the stabilization of neuronal microtubules [3 ]. CNC bioinformatics analysis found a potential co-expression relationship of BANCR with MMP2 and MMP1, which suggested us lncRNA BANCR might have similar function or regulative relation to MMP2/ MMP1.…”

“…In western countries, it has the highest incidence of cancers affecting women [1]. The incidence of EC has signi icantly increased recently because of the expansion of high-risk groups, such as women with high leptin or adiponectin levels [2,3]. In 1983, EC was divided into two types by its micro-morphological, clinical and epidemiological characteristics by Bokhman [4].…”

The expression and significance of histone lysine methylation in endometrial cancer

“…Lamina propria consists of endometrial stromal cells (ESCs), immune cells, reticular fibers, matrix, blood vessels and nerves, forming the microenvironment of the epithelial cells. Tan et al (27) demonstrated that the epithelial-to-mesenchymal transition of prostate cancer cells was inhibited by adiponectin (ADN), which is also inversely correlated with the risk of endometrial cancer (28), with decreasing expression levels of H3K27me3 at the ADN promoter in 22RV1cells (a human prostate cancer cell line). To date, to the best of our knowledge, no previous study has focused on the association between adiponectin and H3K27me3 in stromal cells of endometrial cancer.…”

Post-Translational Modification of Adiponectin Affects Lipid Accumulation, Proliferation and Migration of Vascular Smooth Muscle Cells

“…In human cancer, Apn is known to suppress cancer vascularization [9, 10]. Proliferation and migration of vascular smooth muscle cell (VSMCs) is one of important mechanisms in AS [11].…”