Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus

Kim, S.T.; Marquard, Kerri L.; Stephens, Sahar M.; Louden, Erica; Allsworth, Jenifer E.; Moley, Kelle H.

doi:10.1093/humrep/deq292

Cited by 74 publications

(58 citation statements)

References 54 publications

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“…Although the significance of these variations in adipokines between the stages of the menstrual cycle is unknown, it is possible they may affect signalling within the hypothalamic-pituitary-ovarian axis required for normal oocyte recruitment and ovulation. Other work has demonstrated that adiponectin signalling may be important to pre-implantation embryonic development and implantation 13 .…”

Section: Adipokinesmentioning

confidence: 99%

Obesity and reproductive function

Klenov¹,

Jungheim²

2014

Current Opinion in Obstetrics &Amp; Gynecology

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SYNOPSISObesity is associated with multiple adverse reproductive outcomes, but the mechanisms involved are largely unknown. Public health scientists studying obesity and its effects on health outcomes have referred to obesity as a "complex system", defined as a system of heterogeneous parts interacting in nonlinear ways to influence the behavior of the parts as a whole 1,22 . By this definition, human reproduction is also a complex system which may explain some of the difficulty in identifying the mechanisms linking obesity and adverse reproductive function. Despite the difficulties, research on obesity and reproduction is important as there is an epidemic of obesity among reproductive age women with associated consequences for future generations. In this review we discuss the adverse reproductive outcomes associated with obesity and data from translational studies of the mechanisms involved. We conclude with a brief discussion of public health policy as it relates to the treatment of infertility in obese women. Keywords fertility; obesity; reproduction; public health MEASURING OBESITY AND REPRODUCTIVE RISKDisentangling the individual components of obesity associated with poor health outcomes is difficult. Body mass index (BMI) or overall body size adjusted for height, is obviously, the most accessible measure of obesity as the tools for measuring BMI are readily available. On the other hand, adiposity (regional or total body fat), adipokine production, and lifestyle components may also contribute individually or together to overall obesity-related health risk. The bulk of the work relating obesity to health risks has focused on chronic diseases, however, we are learning more about components of obesity that relate to reproductive risk.

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Section: Adipokinesmentioning

confidence: 99%

Obesity and reproductive function

Klenov¹,

Jungheim²

2014

Current Opinion in Obstetrics &Amp; Gynecology

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“…For the adipocytokine signaling pathway, both adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) were identified. Expression of these receptors also has been described in human and murine endometrium during the window of implantation time and in preimplantation endometrium, respectively [34,35]. Highest mRNA concentrations for genes coding for enzymes involved in fatty acid metabolism, such as acylcoenzyme A (CoA) synthetases; acyl-CoA dehydrogenase (ACADL); carnitine palmitoyltransferases, acetyl-CoA acyltransferase 2 (ACAA2); acetyl-CoA carboxylase beta (ACACB); enoyl-CoA delta isomerase 2 (ECI2); hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (HADHB); and ELOVL fatty acid elongase 5 (ELOVL5), were observed on Days 8 and 12 of the estrous cycle, indicating increased fatty acid synthesis, which is needed for provisioning of the preattachment equine conceptus (in case of pregnancy) with essential fatty acids and retinoids.…”

Section: Genes With Highest Mrna Concentrations During the Luteal Phasementioning

confidence: 99%

Exploration of Global Gene Expression Changes During the Estrous Cycle in Equine Endometrium1

Gebhardt¹,

Merkl²,

Herbach³

et al. 2012

Biology of Reproduction

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The equine endometrium exhibits characteristic morphological and functional changes during the estrous cycle controlled by the interplay of progesterone and estradiol. A microarray analysis of endometrial tissue samples derived from five time points of the estrous cycle (Day [D] 0, D3, D8, D12, and D16) was performed to study the dynamics of equine endometrial gene expression. Statistical analysis revealed 4996 genes differentially expressed during the estrous cycle. Clustering of similar expression profiles was performed to find groups of coregulated genes. This revealed eight major profiles: highest mRNA concentrations on D0, from D0 to D3, on D3, from D3 to D8, on D8, from D8 to D12, from D12 to D16, and on D16. Bioinformatics analysis revealed distinct molecular functions and biological processes for the individual expression profiles characterizing the different phases of the estrous cycle (e.g., extracellular matrix and inflammatory response during the estrus phase, cell division and cell cycle during early luteal phase, and endoplasmic reticulum, protein transport, and lipid metabolism in the luteal phase). A comparison to dynamic gene expression changes in bovine endometrium identified common and species-specific gene regulations in cyclic endometrium. Analysis of expression changes during the estrous cycle for genes previously found to be differentially expressed on D12 of pregnancy provided new evidence for possible regulation of these genes. This study provides new insights regarding global changes of equine endometrial gene expression as molecular reflections of physiological changes in the cyclic equine endometrium with regard to the crucial role of this tissue for successful reproduction.

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“…D'autre part, les taux plasmatiques d'adiponectine sont fortement diminués chez des patientes atteintes de diabète gestationnel, du syndrome des ovaires polykystiques (SOPK), mais aussi d'endométriose et de cancer de l'endomètre (voir [18]). Ces études suggèrent qu'une modification de l'expression de l'adiponectine et/ou de ses récepteurs pourrait être impliquée dans la réceptivité endométriale [38,39]. De plus, une dérégulation de l'expression de ce système pourrait survenir dans certaines conditions pathologiques associées à des fausses couches ou à des pathologies de l'implantation [39].…”

Section: Rôle De L'adiponectine Et De La Résistine Au Cours De L'implunclassified

“…Ces études suggèrent qu'une modification de l'expression de l'adiponectine et/ou de ses récepteurs pourrait être impliquée dans la réceptivité endométriale [38,39]. De plus, une dérégulation de l'expression de ce système pourrait survenir dans certaines conditions pathologiques associées à des fausses couches ou à des pathologies de l'implantation [39]. Contrairement à l'adiponectine, peu de données sont disponibles à ce jour sur un rôle potentiel de la résistine lors de l'implantation de l'embryon.…”

Section: Rôle De L'adiponectine Et De La Résistine Au Cours De L'implunclassified