Adiponectin: a relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity?

Bouskila, Michale; Pajvani, Utpal B.; Scherer, Philipp E.

doi:10.1038/sj.ijo.0802908

Cited by 147 publications

(105 citation statements)

References 49 publications

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“…We also examined whether fish oil might promote adiponectin secretion through activation of PPAR␥. Thiazolidinediones are synthetic ligands of PPAR␥ and have been shown to induce expression of the adiponectin gene and increase adiponectin levels both in vivo and in vitro (23)(24)(25). We found that acute and chronic fish oil treatment resulted in an approximately twofold increase in the expression of the adiponectin gene in epididymal fat, which was paralleled by an approximately two-to threefold increase in the expression of the PPAR␥-responsive gene CD36.…”

Section: Discussionmentioning

confidence: 56%

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

et al. 2006

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Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations twoto threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 h, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)␥ inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPAR␣-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPAR␥-dependent and PPAR␣-independent manner in epididymal fat. Diabetes 55: 924 -928, 2006

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Section: Discussionmentioning

confidence: 56%

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

et al. 2006

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“…HMW isoform may also be, as the major active form, preferentially utilized by liver or other target organs. 16,37 The study presents limitations that should be acknowledged. Quantification of the adiponectin isoforms was performed using semiquantitative WB method.…”

Section: Discussionmentioning

confidence: 99%

“…The oxidizing environment within the lumen of endoplasmic reticulum favors disulfide bond formation through which trimers can further associate into middle-molecular weight (MMW) hexamers and high-molecular weight (HMW) multimers composed of 12 --18 monomers. 16,17 Mechanisms that regulate formation and distribution of adiponectin complexes in human AT and the contribution of different AT depots to circulating levels of particular isoforms are not known so far. The major biological effects of adiponectin in liver, muscle and endothelium have been attributed to HMW isoform of adiponectin.…”

Section: Introductionmentioning

confidence: 99%

The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue

et al. 2011

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OBJECTIVE: Hypoadiponectinemia observed in obesity is associated with insulin resistance, diabetes and atherosclerosis. The aim of the present study was to investigate secretion of adiponectin and its multimeric isoforms by explants derived from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese and non-obese subjects. DESIGN: Paired samples of SAT and VAT and blood samples were obtained from 23 subjects (10 non-obese and 13 obese) undergoing elective abdominal surgery. Total adiponectin quantities and adiponectin isoforms were measured in conditioned media of explants derived from SAT and VAT using enzyme-linked immunosorbent assay and non-denaturing western blot, respectively. RESULTS: Total adiponectin plasma levels were lower in obese than in non-obese subjects (Po0.05). Secretion of total adiponectin in adipose tissue (AT) explants was lower in obese than in non-obese subjects in SAT (Po0.05) but not in VAT. In both, SAT and VAT, the most abundant isoform released into conditioned media was the high-molecular weight (HMW) form. Its relative proportion in relation to total adiponectin was higher in conditioned media of explants from both fat depots when compared with plasma (Po0.001). The proportion of secreted HMW vs total adiponectin was higher in VAT than in SAT explants in the group of non-obese individuals (49.3 ± 3.1% in VAT vs 40.6 ± 2.8% in SAT; Po0.01), whereas no difference between the two depots was found in obese subjects (46.2 ± 3.0 % in VAT vs 46.0 ± 2.4 % in SAT). CONCLUSION: Obesity is associated with the decrease of total adiponectin secretion in SAT. The profile of adiponectin isoforms secreted by SAT and VAT explants differs from that in plasma. Secretion of total adiponectin and HMW isoform of adiponectin are different in obese and non-obese subjects in relation to AT depot.

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“…31 Ablation of the ADN gene in mice results in insulin resistance, glucose intolerance, dyslipidemia and increased susceptibility to vascular injury and atherosclerosis. [32][33][34] Adiponectin reverses these abnormalities by stimulating oxidation of fatty acids, suppressing gluconeogenesis, inhibiting monocyte adhesion and inhibiting macrophage transformation, as well as proliferation and migration of smooth muscle cells in blood vessels. 17,32,35 In our study, we observed an improvement in both insulin resistance and adiponectinemia in losartan-treated patients.…”

Section: Correlationsmentioning

confidence: 99%

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

et al. 2010

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We planned a randomized, double blind clinical trial to evaluate whether an antihypertensive intervention at the proximal or distal level of the renin-angiotensin-aldosterone system could have different effects on a broad range of innovative cardiovascular risk biomarkers. A total of 288 hypertensive Caucasian patients (115 men and 113 women), aged X18 years, were enrolled in this study. They were randomized to take losartan 50 mg per day or ramipril 5 mg per day for 1 month and titrated up to 100 mg per day and 10 mg per day for 13 months, respectively. At baseline, 1, 2 and 14 months after therapy initiation, we evaluated the following parameters: body weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), M-value, adiponectin (ADN), resistin (r), retinol binding protein-4 (RBP-4), visfatin, vaspin, high-sensitivity C-reactive protein (Hs-CRP), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). No variation of body weight, BMI, FPG or vaspin was obtained with either treatment. We recorded a similar improvement in SBP, DBP and Hs-CRP with both treatments; however, losartan also increased M-value, ADN and visfatin, whereas ramipril did not. Furthermore, losartan decreased r, RBP-4, MMP-2 and MMP-9, whereas ramipril did not have any effect on these parameters. In conclusion, we observed that short-term treatment with losartan improved several metabolic parameters (M-value, ADN, RBP-4, r and visfatin) and decreased vascular remodeling biomarkers (MMP-2 and MMP-9) in hypertensive subjects, whereas ramipril did not.

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Adiponectin: a relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity?

Cited by 147 publications

References 49 publications

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

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