Adiponectin: A Predictor for Breast Cancer Survival?

Abstract

European Journal of Breast Health (Eur J Breast Health) is an international, scientific, open access periodical published by independent, unbiased, and double-blinded peer-review principles. It is the official publication of the Turkish Federation of Breast Diseases Societies, and Senologic International Society is the official supporter of the journal.

Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort

“…Higher circulating leptin has been associated with increased recurrence and mortality for all breast cancers 20 or only ER positive tumors 22 , while lower leptin immunostaining was related to more recurrences and poorer overall survival 28 , 29 . Peripheral adiponectin concentrations above the mean/median were associated with lower breast cancer specific mortality (BCM) 21 , better disease-free survival 23 , 24 , and lower recurrence in ER negative breast cancer only 19 , whereas expression in triple negative breast cancer was not associated with survival 30 . Circulating resistin concentrations were found to be associated with shorter 27 or longer survival of breast cancer patients 26 , and tissue expression of resistin was related to higher all-cause mortality 31 and hormone receptor negative disease 32 .…”

Associations of insulin resistance and inflammatory biomarkers with endometrial cancer survival: The Alberta endometrial cancer cohort study

“…Furthermore, comorbid conditions such as obesity, Only one study to date has examined the relationship between adipokines (leptin and adiponectin) and endometrial cancer survival and did not observe an association between adiponectin levels and overall survival in women with type 1 endometrial cancer. 19 In breast cancer cohorts, higher levels of adiponectin measured prior to surgery [37][38][39] and approximately 24 months post-diagnosis 33 have been associated with better prognosis; however, no associations have been found for leptin. 30,37,38,40 In the current study, higher levels of presurgical adiponectin were associated with improved survival outcomes; however, no associations were found for adiponectin measured postsurgery.…”

Altered Serum Marker of Adipokines Profile in Breast Cancer Women

“…Ghrelin is a multifunctional peptide with 28 amino acids hunger-stimulating peptide, Principally secreted by the stomach, and has been characterized as the ligand of the growth hormone secretagogue receptor (GHSR) with physiological actions ranging from hormonal secretion, regulation of food intake, modulation of insulin secretion, adipogenesis and gastrointestinal motility, energy homeostasis, body mass regulation through mechanisms independent from growth hormones.and one of the most important orexigenic peptides currently known (26)(27)(28) .It was implicated in various processes of cancer progression including cell proliferation, cell migration and invasion, angiogenesis, and apoptosis, probably via an autocrine/paracrine mechanism (29) . Serum ghrelin levels were significantly higher than normal control indicated a compensatory mechanism triggered by cachectic catabolic-anabolic imbalance (30) .…”