Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes&#x0D;
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Karásek, David; Krystynik, Ondrej; Kučerová, Veronika; Macakova, Dominika; Cibičková, Ľubica; Schovánek, Jan; Haluzı́k, Martin

doi:10.3390/jcm11092417

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…However, it appears that obesity in early pregnancy may also influence adipokines production. In our previous study we demonstrated increased adipocyte fatty acid-binding protein and decreased adiponectin levels and its correlation with visceral adiposity in women with impaired FPG in early pregnancy [ 14 ]. In contrast to higher body weight in early pregnancy, the overall weight gain was lowest in women with early GDM diagnosis in the present study.…”

Section: Discussionmentioning

confidence: 99%

Fasting Plasma Glucose and Its Relationship to Anthropometric Phenotype in Women Diagnosed with Gestational Diabetes According to IADPSG Criteria

Krystynik

Macakova

Cibičková

et al. 2023

Life

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Background: Gestational diabetes mellitus (GDM) is characterized by new-onset hyperglycemia in pregnancy. According to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommendations, GDM may be diagnosed based on repeatedly increased fasting glucose levels in the first trimester, or later, the detection of increased fasting glucose and/or increased glucose levels during a 75 g oral glucose tolerance test (OGTT). The study aimed to assess whether differences may be found between women diagnosed with GDM by fasting glucose or glucose challenge tests in early or late pregnancy. Methods: The retrospective observational study enrolled 418 women diagnosed with GDM in accordance with the IADPSG criteria: early pregnancy fasting plasma glucose (FPG) ≥ 5.1 mmol/L; late pregnancy FPG ≥ 5.1 mmol/L (0 min) and/or postprandial plasma glucose (PPG) ≥ 10.0 mmol/L (60 min), PPG ≥ 8.5 mmol/L (120 min) 75 g OGTT. The analyses included anthropometric parameters at the beginning and during pregnancy, laboratory values of glycated hemoglobin, fructosamine, birth weight measures and the presence of neonatal complications. Results: There were significant differences in body weight (78.3 ± 19.1; 74.0 ± 16.7; 67.2 ± 15.7 kg) and body mass index (BMI) (27.9 ± 6.6; 26.4 ± 5.8; 24.4 ± 5.2 kg/m2) in early pregnancy. Differences were also found in gestational weight gain (9.3 ± 6.8 vs. 12.4 ± 6.9 vs. 11.1 ± 4.7 kg) and the need for insulin therapy (14.7%; 7.1%; 4.0%). The study revealed no difference in the presence of neonatal complications but differences in birth weight (3372.2 ± 552.2 vs. 3415.6 ± 529.0 vs. 3199.0 ± 560.5 g). Conclusions: Gestational diabetes, characterized by FPG ≥ 5.1 mmol/L in early pregnancy, is associated with higher body weight and BMI at the beginning of pregnancy as well as with a higher risk for insulin therapy and increased birth weight.

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Section: Discussionmentioning

confidence: 99%

Fasting Plasma Glucose and Its Relationship to Anthropometric Phenotype in Women Diagnosed with Gestational Diabetes According to IADPSG Criteria

Krystynik

Macakova

Cibičková

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, we have also found in women with early GDM altered adipokines production (increased adipocyte fatty acid-binding protein and decreased adiponectin levels) that correlated with visceral adiposity and glucose control. The introduction of lifestyle interventions during pregnancy and early GDM treatment was associated with not only prevention of weight gain and with glycemic compensation, but also normalization of adipokines levels [ 31 ]. These findings support the possible role of endocrine dysfunction of adipose tissue in the development of GDM.…”

Section: Discussionmentioning

confidence: 99%

Non-altered incretin secretion in women with impaired fasting plasma glucose in the early stage of pregnancy: a case control study

Krystynik

Karásek

Kahle

et al. 2023

Diabetol Metab Syndr

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Backgrounds Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) may be involved in pathogenesis of gestational diabetes mellitus (GDM). The aim was to compare GLP-1 and GIP production in fasting state and during 3 h mixed meal tolerance test (MMTT) measured by mean area under the curve (AUC) between pregnant women with normal and impaired fasting glucose in an early phase of pregnancy, and healthy non-pregnant controls. Methods This study was undertaken as a case–control study. Repeated measurement of fasting plasma glucose ≥ 5.1 mmol/L and < 7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes according to IADSPG criteria was used to find women with impaired fasting glucose (n = 22). Age-matched controls consisted of healthy pregnant (n = 25) and non-pregnant (n = 24) women. In addition to incretins, anthropometric parameters and markers of insulin resistance and beta-cell function were assessed. Variables were summarized as median (interquartile range). Results Fasting GLP-1 and GIP concentration or their AUC during MMTT did not significantly differ between pregnant women with impaired fasting plasma glucose [GLP-1AUC 19.0 (53.1) and GIPAUC 302 (100) pg/mL/min] and healthy pregnant women [GLP-1AUC 16.7 (22.3) and GIPAUC 297 (142) pg/mL/min] or non-pregnant controls [GLP-1AUC 16.8 (9.8) and for GIPAUC 313 (98) pg/mL/min]. Although women with impaired fasting glucose were more obese and showed decreased beta-cell function, there were not significant correlations between incretin production and parameters of insulin secretion, insulin resistance, or obesity. Conclusions Women with impaired fasting plasma glucose did not show altered incretin production in the first trimester of pregnancy. In contrast to type 2 diabetes, impaired incretin secretion does not seem to play a major role in the early development of GDM.

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“…Women with early onset GDM also showed altered adipokine production. Increased A-FABP and decreased adiponectin levels are correlating with visceral adiposity and glucose control and may be affected by treatment later in pregnancy [127].…”

Section: Gestational Diabetes Mellitus (Gdm)mentioning

confidence: 99%

Intensive Management of Type 1 Diabetes in Adults: One Centre Experience 1970–2022

Chlup¹,

Krystynik²,

Mlčák³

et al. 2023

Type 1 Diabetes in 2023 - From Real Practice to Open Questions

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This chapter deals with clinical trials and routine management of persons with type 1 diabetes (PWD1) carried out at the Teaching Hospital and Palacký University Olomouc since 1970 in cooperation with experts from other centres. The following outcomes are presented: (1) physical training resulted in (a) enhancement of physical working capacity; (b) increased insulin effectiveness (c) increased S-HDL cholesterol; (d) improvement of neuropathy, memory, attention and general condition of PWD1. (2) Intensive basal and prandial insulin substitution with only short-acting insulin given seven times a day and night appeared to be the most effective approach to the conventional insulin substitution; group education and pens motivated to the intensification of insulin therapy. (3) Continuous subcutaneous insulin infusion, conventional self-monitoring, continuous/flush glucose monitoring and prolongation of time in range opened new horizons. Intensive education, early application of hybrid insulin pumps and specialised prevention of late diabetes complications are deemed to improve the life expectancy and quality. Cooperation with insurance companies should be acknowledged.

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Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Cited by 5 publications

References 35 publications

Fasting Plasma Glucose and Its Relationship to Anthropometric Phenotype in Women Diagnosed with Gestational Diabetes According to IADPSG Criteria

Fasting Plasma Glucose and Its Relationship to Anthropometric Phenotype in Women Diagnosed with Gestational Diabetes According to IADPSG Criteria

Non-altered incretin secretion in women with impaired fasting plasma glucose in the early stage of pregnancy: a case control study

Intensive Management of Type 1 Diabetes in Adults: One Centre Experience 1970–2022

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