Adipokines Vaspin and Visfatin in Obese Children

Salama, H. M.; Galal, Ashraf; Motawie, Ayat A.; Kamel, Ashraf; Ibrahim, Doaa; Aly, Azza Ahmed; Hassan, Emman A.

doi:10.3889/oamjms.2015.123

Cited by 17 publications

(15 citation statements)

References 26 publications

(22 reference statements)

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“…Additionally, the serum vaspin concentration in obese patients was higher than that in nonobese patients in the same research [ 17 ]. Salama et al (2015) found that vaspin levels are increased in obese children and identified correlations between vaspin concentration and WHR; however, they concluded that vaspin was a less sensitive indicator of abdominal obesity and insulin resistance in obese children compared with visfatin [ 20 ]. Cekmez et al reported that large for gestational age children had a higher vaspin concentration than those who were appropriately sized for gestational age [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Yang

Tian

et al. 2017

BioMed Research International

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Aims. This study was to evaluate the association of serum vaspin concentrations with body mass index (BMI) among elderly patients (>60 years old). Methods. A total of 227 elderly individuals included 76 healthy with normal glucose tolerance, which divided into normal weight control (BMI < 25, n = 38) and overweight or obese control (BMI ≥ 25, n = 38) subgroups, and 150 T2DM patients, which divided into normal weight diabetes (BMI < 25, n = 55), overweight diabetes (30 > BMI ≥ 25, n = 52), and obese diabetes (BMI ≥ 30, n = 43) subgroups. Relevant parameters were matched for age and gender ratio. Serum vaspin concentrations were measured by enzyme-linked immunosorbent assay. Results. Serum vaspin concentration was significantly higher in the T2DM than the healthy (451.9 ± 32.6 versus 284.2 ± 21.7, P < 0.01). In the diabetic patients, the vaspin concentration was significantly higher in the obese group than the normal weight group (498.2 ± 17.1 versus 382.1 ± 21.3, P < 0.05). In addition, the concentration of vaspin in normal weight T2DM was higher than in healthy control group with normal weight (382.1 ± 21.3 versus 192.5 ± 45.2, P < 0.05). Multiple regression analysis revealed that BMI was independent factors influencing the serum vaspin concentration in all participants. Conclusion. Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. The clinical trial registration number is ChiCTR-OPC-14005698.

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Section: Discussionmentioning

confidence: 99%

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Yang

Tian

et al. 2017

BioMed Research International

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“…Apart from these well-studied adipocytokines, a large number of additional adipokines emerged during the last years, including adipocyte-fatty acid-binding protein (A-FABP), retinol binding protein 4 (RBP4), lipocalin-2, omentin-1, and vaspin [48, 58, 64] (Table 2). Some of these may be promising biomarkers in the context of metabolic disturbances.…”

Section: The Role Of Adipocytokines In the Pathogenesis Of Metabolic mentioning

confidence: 99%

“…NAMPT is significantly associated with several anthropometric parameters (BMI, waist circumference, and hip circumference) [64], components of MetS, and inflammation [48] in children. While Kotnik et al [48] found no association between NAMPT and insulin resistance, Salama et al [64] demonstrated a significant link between NAMPT and an impaired homeostatic model assessment for insulin resistance (HOMA-IR).…”

Section: The Role Of Adipocytokines In the Pathogenesis Of Metabolic mentioning

confidence: 99%

Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Bussler¹,

Penke²,

Flemming³

et al. 2017

Horm Res Paediatr

105

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Metabolic syndrome (MetS) is recognized as an escalating major health risk in adults as well as in children and adolescents. Its prevalence ranges from 6 to 39% depending on the applied definition criteria. To date, there is no consensus on a MetS definition for children and adolescents. However, most authors agree on essential components such as glucose intolerance, central obesity, hypertension, and dyslipidemia; each representing a risk for cardiovascular disease. Recently, associations between MetS and non-alcoholic fatty liver disease, hyperuricemia, and sleep disturbances have emerged. Biomarkers like adipocytokines are a subject of current research as they are implicated in the pathogenesis of the MetS. Epigenetics and gestational programming, especially the role of microRNA, comprise a novel, rapidly developing and promising research focus on the topic of MetS. MicroRNAs are increasingly valued for potential roles in the diagnosis, stratification, and therapeutics of MetS. Early detection of risk factors, screening for metabolic disturbances, and the identification of new therapies are major aims to reduce morbidity and mortality related to MetS. Dietary modification and physical activity are currently the only adopted treatment approaches. Pharmacological therapies and bariatric surgery are still contradictory and, therefore, are only recommended in selected high-risk cases.

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“…The serum vaspin levels were decreased in CF children like in ischemic heart disease and girlswith anorexia nervosa [30][31][32]. Decreased serum vaspin concentrations may simply reflect reduced fat mass in CF like in obese subjects after 12-weeks short term weight reduction program [33].…”

Section: Discussionmentioning

confidence: 97%

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

Machura¹,

Ziora²,

Szczepańska³

et al. 2017

Pediatr. Endocrinol.

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Introduction. Patients with cystic fibrosis (CF) present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentration. The aim of the study is to evaluate serum concentration of chemerin, omentin and vaspin in children with cystic fibrosis. Material and Methods. The study group included 21 children (mean age 11.3±0.4 years) with stable CF. The diagnosis of CF was established by sweat test and later confirmed by genetic examination in all subjects. Patients with pulmonary exacerbation were excluded from study. In all children history, physicalexamination, anthropometric parameters, sputum, blood samples, and lung function tests were assessed.The control group consisted of 22 healthy children (mean age 10.9 ±4.4years). Results. The mean serum levels of chemerin and omentin were higher (p<0.001) in CF children than in healthy children. The mean serum vaspin concentration was significantly lower than in controls (p<0.001). Concentrations of examined adipokines showed no correlation with BMI, BMI-SDS, Słowa kluczowe mukowiscydoza, chemeryna, omentyna, waspina, dzieci Streszczenie Wstęp. Pacjenci z mukowiscydozą (cysticfibrosis, CF) prezentują liczne patologiczne stany, jak niedożywienie, zmniejszenie masy tłuszczowej ciała, zaburzenia metaboliczne (zaburzony metabolizm glukozy, wzrost insulinooporności, przewlekły deficyt energii, miejscowe i chroniczne zapalenie), które mogą mieć związek z zaburzeniami stężeń adipokin. Celem badań jest ocena stężenia chemeryny, omentyny i waspiny w surowicy krwi u dzieci z mukowiscydozą. Materiał i metody. Badaniami objęto21 dzieci (średni wiek: 11,7± 1,59 lat) ze stabilną CF. Diagnozę CF u tych dzieci potwierdzono badaniem genetycznym. Pacjentów z zaostrzeniem choroby wykluczono z badań. U wszystkich dzieci przeprowadzono wywiad, badanie fizykalne i antropometryczne, zbadano plwocinę, pobrano krew, wykonano czynnościowe badania płuc. Grupę kontrolną stanowiło 22 zdrowych dzieci (średni wiek: 10,9 ± 4,4 lat). Wyniki. Średnie stężenie chemeryny i omentyny w surowicy krwi było istotnie wyższe (p<0.001), a waspiny znamiennie niższe (p<0,001) u dzieci z mukowiscydozą aniżeli u zdrowych. Nie stwierdzono znamiennych statystycznie korelacji pomiędzy stężeniem badanych adipokin we krwi a BMI, BMI-SDS, glukozą, cholesterolem całkowitym, LDL i HDL we krwi. FEV1 i FVC Praca oryginalna

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Adipokines Vaspin and Visfatin in Obese Children

Cited by 17 publications

References 26 publications

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

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