Adipokines: New Emerging Roles in Fertility and Reproduction

Tersigni, Chiara; Nicuolo, Fiorella Di; D’Ippolito, Silvia; Veglia, Manuela; Castellucci, Mario; Simone, Nicoletta Di

doi:10.1097/ogx.0b013e318217b0a4

Cited by 50 publications

(47 citation statements)

References 152 publications

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“…The traditional view of the adipose tissue as a passive store of dormant triglycerides, which are mobilized during NEB, has been challenged by recent research that has shown that the adipose tissue also secretes a variety of hormones collectively known as the adipokines (Tersigni et al, 2011). Leptin, adiponectin and resistin are the three best studied adipokines in relation to ovarian function in ruminants.…”

Section: Metabolic Hormonesmentioning

confidence: 99%

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The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

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The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

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Section: Metabolic Hormonesmentioning

confidence: 99%

“…Leptin, adiponectin and resistin are the three best studied adipokines in relation to ovarian function in ruminants. These hormones are significant mediators of energy metabolism and they have all been implicated as mediators of nutritional influences on reproduction (Tersigni et al, 2011).…”

Section: Metabolic Hormonesmentioning

confidence: 99%

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

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“…8 In addition, adipocytokines may have a role in the critical process of trophoblast invasion and successful placentation, which requires appropriate angiogenesis, as previously reviewed. 9 Therefore, adipocytokines may be of pathophysiological significance for both PE 10,11 and many CVD including hypertension. 12 Visfatin is a recently described adipocytokine, also known as nicotinamide phosphorybosil transferase (NAMPT), which has a potential role in the pathophysiology of metabolic disorders such as hypertension and obesity.…”

Section: Introductionmentioning

confidence: 99%

Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy

et al. 2015

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Dysregulation of adipocytokines may be associated with endothelial dysfunction in women with preeclampsia (PE), who are at increased risk of future cardiovascular disease. Visfatin, an adipocytokine with a potential cardiovascular role, is also known as nicotinamide phosphorybosil transferase (NAMPT). NAMPT gene polymorphisms affect circulating visfatin/NAMPT levels in obesity. Most findings provide evidence for increased visfatin/NAMPT circulating levels in PE. However, no previous study has tested the hypothesis that NAMPT polymorphisms affect visfatin/NAMPT levels in hypertensive disorders of pregnancy. We studied the effects of the NAMPT polymorphisms T>C (rs1319501) and A>G (rs3801266), and the haplotypes formed by them on visfatin/NAMPT levels and whether these genetic markers are associated with gestational hypertension (GH) and PE. We studied 212 healthy pregnant (HP), 181 patients with GH and 208 with PE. Genotypes were determined by Taqman allele discrimination assays. Plasma visfatin/NAMPT levels were measured by ELISA. No significant differences in visfatin/NAMPT levels were found among the groups. However, higher visfatin/NAMPT levels (P<0.05) were found in GH patients carrying the AG or the GG genotypes for the rs3801266 polymorphism or the 'T, G' haplotype. The TC and CC genotypes and the C allele for the rs1319501 polymorphism were more frequent in the HP than in the PE group (P<0.05). Moreover, the 'C, A' haplotype was also more frequent in the HP than in the PE group (P<0.01). Our findings suggest that although the rs3801266 polymorphism and the 'T, G' haplotype affect visfatin/NAMPT levels in GH, the rs1319501 polymorphism and the 'C, A' haplotype affect the susceptibility to PE.

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“…By now, adipose tissue is considered a major endocrine organ, with more than 600 potentially secreted proteins identified so far 2, 4, 5. These proteins, termed adipokines, exert endo-, para-, and autocrine effects and have been linked to biological processes like metabolism, immunity and fertility 6-8. Furthermore, relationships with adverse health conditions like metabolic syndrome, cardiovascular disease, psoriasis and dementia have been established 9-12.…”

Section: Introductionmentioning

confidence: 99%

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Komolka¹,

Albrecht²,

Wimmers³

et al. 2014

J. Genomics

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Adipose tissue is considered as a major endocrine organ that secretes numerous proteins called adipokines. The heterogeneous nature of adipose tissue in different parts of the body suggests respective heterogeneity of proteomes and secretomes. This review consolidates knowledge from recent studies targeting the diversity of different adipose depots affecting the pattern of secreted adipokines and discusses potential consequences for the cross-talk between adipose and skeletal muscle in humans, rodent models and farm animals. Special attention is paid to muscle-associated fat depots like inter- and intramuscular fat that become focus of attention in the context of the rather new notion of skeletal muscle as a major endocrine organ. Understanding the complexity of communication between adipocytes and skeletal muscle cells will allow developing strategies for improvement of human health and for sustainable production of high quality meat.

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Adipokines: New Emerging Roles in Fertility and Reproduction

Cited by 50 publications

References 152 publications

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

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