Adipokines Level and Cognitive Function—Disturbance in Homeostasis in Older People with Poorly Managed Hypertension: A Pilot Study

Kujawska, Agnieszka; Kujawski, Sławomir; Kozakiewicz, Mariusz; Hajec, Weronika; Kwiatkowska, Małgorzata; Skierkowska, Natalia; Husejko, Jakub; Newton, Julia L.; Zalewski, Paweł; Kędziora–Kornatowska, Kornelia

doi:10.3390/ijerph19116467

Cited by 1 publication

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References 56 publications

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“…There could be a third confounding factor that affects the two initial variables. It is therefore possible that there is not a simple unilateral relationship between sclerostin and cardiovascular risk, since there could be other underlying factors that are not currently being evaluated, as occurs in other processes detailed in scientific literature [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Sclerostin as a Biomarker of Cardiovascular Disease and Mortality: A Scoping Review

Torre

González-Salvatierra

García-Fontana

et al. 2022

IJERPH

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Sclerostin is most recognized for its role in controlling bone formation; however, it is also expressed in the heart, aorta, coronary, and peripheral arteries. Human studies have associated high circulating sclerostin levels with the presence of different cardiovascular diseases (CVD), surrogate CVD markers, and a high risk of cardiovascular events in some populations. However, this is still a matter of scientific debate, as the results have been very heterogeneous among studies. In the present review, the association between serum sclerostin levels and CVD and/or cardiovascular mortality was analyzed. For this purpose, a scoping review was performed in which articles measuring serum sclerostin levels and cardiovascular risk in patients were selected. Eleven articles answered the research question; of these articles, 8/11 evaluated the association between sclerostin and CVD, of which 4/8 found a positive association, 2/8 found a negative association, and 2/8 found no association between variables. Five (5/11) of the articles included in the study evaluated cardiovascular mortality, of which 3/5 found a positive association, 1/5 found a negative association, and 1/5 found no association between variables. In conclusion, we did not find sufficient results to be able to demonstrate an association between elevated sclerostin levels and the development of CVD and/or cardiovascular mortality in the general population due to heterogeneity in the results. However, there seems to be a tendency to consider increased sclerostin levels as a risk factor for both the development of cardiovascular events and cardiovascular mortality in specific populations. Further studies in this field will help to solve some of the inconsistencies found during this scoping review and allow for the future use of sclerostin measurement as a strategy in the prevention and diagnosis of CVD and/or cardiovascular mortality.

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Section: Discussionmentioning

confidence: 99%