Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study

Lee, Christine G.; Carr, Maria; Murdoch, Susan J.; Mitchell, Ellen Sullivan; Woods, Nancy Fúgate; Wener, Mark H.; Chandler, Wayne L.; Boyko, Edward J.; Brunzell, John D.

doi:10.1210/jc.2008-0701

Cited by 235 publications

(172 citation statements)

References 36 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…Women exhibit a tendency toward visceral fat accumulation during the menopausal transition, though it is difficult to separate the influence of menopause from the natural tendency toward fat accumulation with age 6, 28. Certainly, mice that are deficient in estradiol (because of a genetic deletion of the gene for aromatase) exhibit an increase in visceral fat and resultant insulin resistance compared with their wild‐type counterparts 29.…”

Section: Discussionmentioning

confidence: 99%

Progression of Metabolic Syndrome Severity During the Menopausal Transition

Gurka

Vishnu

Santen

et al. 2016

JAHA

124

View full text Add to dashboard Cite

BackgroundAfter menopause, women exhibit a higher prevalence of the metabolic syndrome (MetS) and higher risk of cardiovascular disease. However, the timing of changes in MetS severity over the menopausal transition and whether these changes differ by racial/ethnic group remain unclear.Methods and ResultsWe assessed data from 1470 women from the Atherosclerosis Risk in Communities cohort who experienced transition in menopausal status over 10 years (visits 1–4). We used linear mixed models to evaluate changes by menopausal status (premenopause, perimenopause, and postmenopause) in a MetS severity Z‐score and in the individual MetS components. While there were gradual increases in MetS severity over time across menopause stages, black women in particular exhibited more rapid progression in MetS severity during the premenopausal and perimenopausal periods than during the postmenopausal period. In the postmenopausal period (compared with prior periods), white women exhibited unfavorable decreases in high‐density lipoprotein, while black women exhibited favorable alterations in the rate of change for waist circumference, triglycerides, high‐density lipoprotein, and glucose, contributing to the slowed progression of MetS severity. These changes were all observed after adjusting for hormone replacement treatment.ConclusionsDuring menopausal transition, women exhibited rapid increases in MetS severity during the premenopausal and perimenopausal periods, with black women having significant reductions in this increase in severity during the postmenopausal period. These data suggest that the higher prevalence of MetS in postmenopausal women may be caused more by changes during the menopausal transition than by postmenopause. These findings may thus have implications regarding the timing of cardiovascular risk relative to menopause.

show abstract

Section: Discussionmentioning

confidence: 99%

Progression of Metabolic Syndrome Severity During the Menopausal Transition

Gurka

Vishnu

Santen

et al. 2016

JAHA

124

View full text Add to dashboard Cite

show abstract

“…Very few randomized controlled trials (RCT) of exercise, independent of any dietary intervention, have studied these questions exclusively in postmenopausal women (22)(23)(24)(25)(26)(27), and findings were conflicting. Postmenopausal women represent a population subgroup that may respond differently to exercise given that female sex and older age have been associated with higher CRP levels (28) that may be partly related to a general increase in intraabdominal adiposity that occurs after menopause (29).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

Friedenreich

Neilson

Woolcott

et al. 2012

Cancer Prevention Research

View full text Add to dashboard Cite

Chronic low-grade inflammation is a possible risk factor for cancer that may be modifiable with long-term exercise. Very few randomized controlled trials (RCT) have studied the isolated effects of exercise on lowgrade inflammation exclusively in postmenopausal women. The Alberta Physical Activity and Breast Cancer Prevention Trial, a 2-armed RCT in healthy postmenopausal women, examined how 1 year of moderate to vigorous aerobic exercise, compared with usual inactivity, influenced circulating inflammatory markers. Baseline, 6-month, and 12-month serum was analyzed by direct chemiluminescent immunoassays to measure high sensitivity C-reactive protein (CRP) and ELISAs to measure interleukin 6 (IL-6) and TNF-a. Intention to treat analyses were conducted with linear mixed models. Statistically significant differences in CRP were observed over 12 months for exercisers versus controls (treatment effect ratio ¼ 0.87, 95% CI ¼ 0.79-0.96, P ¼ 0.005), but not in IL-6 or TNF-a. A statistically significant trend (P trend ¼ 0.021) of decreasing CRP with increasing exercise adherence and stronger intervention effects on CRP in women with higher baseline physical fitness (P heterogeneity ¼ 0.040) was found. The intervention effect on CRP became statistically nonsignificant with adjustment for dietary fiber intake change and seemed to be mediated by fat loss. Low-grade inflammation may be lowered with exercise, but confounding by dietary intake occurred and should be considered in future studies. Further trials are needed to corroborate our findings about the optimal dose of exercise required to lower CRP levels and effect modification of CRP changes by levels of body fatness and fitness. Cancer Prev Res; 5(1); 98-108. Ó2011 AACR.

show abstract

“…In the study, the subcutaneous adipose tissue increased in accordance with age independent of menopausal status, while the findings of increased visceral adipose tissue and total body fat were noted only in postmenopausal women. This distinctive physiologic change in amount and distribution of fat in women is noteworthy because the central fat deposition has a more deleterious effect on the development of cardiovascular and metabolic disease [24,25]. Although the exact mechanism regarding fat redistribution after menopause remains unclear, the phenomenon with declining estrogen level may be due to alterations in adipose tissue metabolism [4].…”

Section: Deposition and Distribution Of Adipose Tissuementioning

confidence: 99%

Adipose Tissue Metabolism and Effect of Postmenopausal Hormone Therapy on Change of Body Composition

Yi¹,

Ku²

2012

Sex Steroids

View full text Add to dashboard Cite

Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study

Abstract: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.

Cited by 235 publications

References 36 publications

Progression of Metabolic Syndrome Severity During the Menopausal Transition

Progression of Metabolic Syndrome Severity During the Menopausal Transition

Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

Adipose Tissue Metabolism and Effect of Postmenopausal Hormone Therapy on Change of Body Composition

Contact Info

Product

Resources

About