Adipokines in osteoarthritis: friends or foes of cartilage homeostasis?

Gegout, P.; Francin, Pierre-Jean; Mainard, Didier; Presle, Nathalie

doi:10.1016/j.jbspin.2008.07.008

Cited by 40 publications

(18 citation statements)

References 6 publications

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“…In accordance with our findings, Choe et al also found that resistin may be strongly associated with radiographic changes in hand OA, demonstrating that resistin expression may have an important role in predicting radiographic outcomes in patient with hand OA [22]. Gegout et al also found that resistin may play a central role in initiating and promoting the development of OA and may be one of the major connections between metabolic disorders related with obesity and the destruction of joint cartilage [23]. Furthermore, our results illustrated that plasma resistin levels of male patients with OA were increased significantly compared with those of female patients, supporting the notion that males may be more prone to develop OA than females.…”

Section: Discussionsupporting

confidence: 90%

“…This could be explained by the role of resistin as an inducer of proinflammatory cytokines including TNF- α , IL-6, and IL-12 through the nuclear factor- κ B signal pathway in diverse inflammatory conditions [22]. Another prevailing hypothesis is that obesity, which has a close link with resistin, may cause increased loads on joint surfaces leading to cartilage wear, a risk for OA, suggesting that resistin may be related with OA through its metabolism functions [23]. Nevertheless, there exist some contrary conclusions and inconsistent studies about these discoveries [21, 24].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

Tian

Wang

2014

BioMed Research International

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Background. The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect. Method. Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model. Results. Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population. Conclusion. These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

Tian

Wang

2014

BioMed Research International

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“…Several studies have linked leptin, obesity and osteoarthritis 27 41–47. For example, serum leptin concentrations correlate with BMI and are closely related to the radiographic severity, joint inflammation and disease severity of osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that locally produced, rather than circulatory, leptin may be more important in regulating cartilage homeostasis because the concentration of leptin in synovial fluid is higher than in the corresponding sera of osteoarthritis patients,29 and these levels are associated with disease activity 26 53. Moreover, expression of leptin and LEPR have previously been detected in human cartilage, with levels significantly increased in end-stage osteoarthritis cartilage 26 41. The endogenous leptin produced by chondrocytes has also been shown to induce MMP13 expression 54.…”

Section: Discussionmentioning

confidence: 99%

“…However, although we could detect leptin and LEPR expression in cartilage, neither were differentially expressed in osteoarthritis in our experiments and the level of leptin expression detected was deemed negligible (see supplementary figure 2, available online only). Therefore, we focused on leptin production by the infrapatellar fat pad, a joint tissue reported to be a site of leptin production 41. For the first time to our knowledge we have shown that WAT-conditioned media, collected from cultured infrapatellar fat pad and other WAT of osteoarthritis knee joints, contains significant quantities of leptin, the amount of which correlated with the ability of the WAT-conditioned media to stimulate MMP1 and MMP13 expression in chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

et al. 2011

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Leptin acts as a pro-inflammatory adipokine with a catabolic role on cartilage metabolism via the upregulation of proteolytic enzymes and acts synergistically with other pro-inflammatory stimuli. This suggests that the infrapatellar fat pad and other WAT in arthritic joints are local producers of leptin, which may contribute to the inflammatory and degenerative processes in cartilage catabolism, providing a mechanistic link between obesity and osteoarthritis.

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Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis

Beattie

MacIntyre²,

Ramadan

et al. 2011

Arthritis Care & Research

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Objectives To quantify rates of change in quadriceps muscle (QM) and intermuscular fat (IMF) volumes over 2-years in women in the Osteoarthritis Initiative (OAI) study and examine group differences between those with radiographic OA (ROA) and those without (non-ROA). Methods The OAI database was queried for women ≥50 years old in the incident and progression cohorts with and without ROA at baseline. Mid-thigh MRI scans (15 contiguous slices, 5 mm slice thickness) of eligible women were randomly selected and anonymized. Image pairs were registered. QM and IMF were segmented in the 12 most proximal matching slices with the segmenter blinded to image time point. Age-adjusted differences in QM and IMF volume changes between groups were tested using ANCOVA. Results 41 women without ROA (mean (SD) age 60.7 (7.6) yrs) and 45 with ROA (mean (SD) age 64.5 (6.7) yrs) were included. Mean QM and IMF volume changes in the non-ROA group were -4.1 (11.1) cm3 and 3.4 (7.1) cm3, respectively, and -5.4 (13.5) cm3 and 3.1 (7.4) cm3 in the ROA group, respectively. Age-adjusted between-group differences in QM and IMF changes were not significant (p>0.05). Conclusions Two-year changes in QM and IMF volume appear consistent with ageing and do not seem to be related to OA status. Direct comparison with a control cohort without OA risk factors could confirm this. Since group assignment was based on baseline data, there may have been women in the non-ROA group who developed radiographic OA over follow-up resulting in some overlap between groups.

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Adipokines in osteoarthritis: friends or foes of cartilage homeostasis?

Cited by 40 publications

References 6 publications

Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis

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