Adipokines in metabolic processes regulating during obesity treatment

Abstract

Bariatric surgery serves as a model for the assessment of the relationship between body mass index (BMI) reduction and changes in adipokine production and for exploring the endocrine function of the pancreas in patients who do not have the proximal part of the small intestine. Aim. of the study was to assess the biochemical parameters and plasma levels of adipokines [adiponectin, adipsin, leptin, plasminogen activator inhibitor (PAI-1), resistin and visfatin], insulin, C-peptide, ghrelin and incretins [glucose insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)] in patients with morbid obesity after surgery (gastric bypass) and therapeutic correction. Materials and methods. A total of 75 patients (34 men and 41 women; age range: 24?67 years) diagnosed as obese were divided into two groups according to the treatment they received. Biochemical analysis was performed to estimate carbohydrate and lipid metabolism rates and plasma levels of adipokines (adiponectin, adipsin, leptin, PAI-1, resistin, visfatin), insulin, C-peptide, ghrelin and incretins (GIP and GLP-1) using the flow fluorometry. Results. Surgical treatment of obesity resulted in a significant decrease in BMI (from 45.67?9.87 to 32.45?5.35 kg/m2, p

Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes

“…Adipsin serum concentrations are reduced in patients with type 2 diabetes (T2D) and ß-cell failure [20]. Furthermore, adipsin facilitates glucose uptake and increases triglyceride synthesis in adipocytes [24]. Mice with a genetic ablation of adipsin are characterized by impaired glucose homeostasis in response to diet-induced obesity [18,20].…”

The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes

“…В ранее проведенном исследовании [12] мы показали отсутствие различий в содержании GIP и GLP-1 натощак у больных МО до коррекционных мероприятий и паци-ентов, перенесших ГШ (через 18 мес), относительно здо-ровых доноров.…”

“…Вопросы патогенеза тами нескольких исследований, показывающих сниже-ние циркулирующего грелина у больных МО [12,16].…”

Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders

“…These diseases are multifactorial, with insufficiently defined initial pathogenic factors. However, based on the opinions of the international community and the studies conducted by our team (over 10 years), in most cases, metabolic complications are associated with inflammation [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Therefore, chronic subclinical inflammation contributes to the disruption of lipid and carbohydrate metabolism, and its local foci lead to dysfunction of various tissues (adipose tissue, liver, vascular endothelium, etc.).…”