Adipokines as novel biomarkers and regulators of the metabolic syndrome

Deng, Yingfeng; Scherer, Philipp E.

doi:10.1111/j.1749-6632.2010.05875.x

Cited by 482 publications

(396 citation statements)

References 215 publications

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“…The mechanism by which adiponectin affects glucose tolerance is not yet fully understood but it has been attributed to its insulin-sensitizing and anti-inflammatory properties [4,5]. A decrease in adiponectin is believed to precede the onset of insulin resistance [4], but this has not yet been proven and has also been questioned [28].…”

Section: Discussionmentioning

confidence: 99%

“…A decrease in adiponectin is believed to precede the onset of insulin resistance [4], but this has not yet been proven and has also been questioned [28]. It remains unclear whether adiponectin has a causal effect on diabetes or is simply acting as a surrogate marker for some other metabolic risk factor(s).…”

Section: Discussionmentioning

confidence: 99%

“…Leptin is a pro-inflammatory adipokine and is closely correlated to obesity severity [2]. Adiponectin, in contrast to leptin, has anti-inflammatory and anti-atherogenic properties, and has been shown to have a positive influence on insulin sensitivity [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Neville

Patterson

Linden

et al. 2016

Diabetes Research and Clinical Practice

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Woodside, J. V. (2016). The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. Diabetes Research and Clinical Practice, 120,[24][25][26][27][28][29][30] Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. Abstract:Aims: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.Methods: Baseline serum levels of leptin and adiponectin were measured in 1839 nondiabetic men aged 50-60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.Results: 151 participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95%CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95%CI 0.14-0.42) relative to men in the bottom third.However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin. Conclusions:This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Neville

Patterson

Linden

et al. 2016

Diabetes Research and Clinical Practice

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“…Even moderate weight loss of about 10% or less has been shown to contribute to several health benefits including improved metabolic parameters, reduced blood pressure, and increased longevity [ Adipose tissue is an endocrine organ with a large and biologically active secretome [180] [181] and fat tissue in obese individuals is characterized by increased expression and / or secretion of several pro-inflammatory cytokines. as well as adipokine to promote inflammation, atherogenesis and insulin resistance, while the biosynthesis of anti-inflammatory, antiatherogenic and insulin-sensitizing adipokines such as adiponectin decreases [182] [183] Several studies have shown an increase in circulating levels of leptin and an increase in adiposity associated with leptin resistance and that this condition may contribute to the onset and / or maintenance of obesity [184]. ]…”

Section: Iii-2-5 Obesitymentioning

confidence: 99%

The effects of the Mediterranean Diet on Chronic Diseases: Cardiovascular Diseases, Oxidative Stress, Dyslipidemia, Diabetes Mellitus, Blood Pressure, Cancer, Neurodegenerative Disease and Obesity

Benyaich¹

2017

jaar

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Poor dietary habits lead to the emergence of chronic diseases such as coronary heart disease, stroke, hypertension, diabetes mellitus, dyslipidemia, cancer, dementia, obesity and oxidative stress involved through the aggression of cells by free radicals, Knowing that these diseases cause a global burden both individually and economically, Several studies focus on the relationship between diet and chronic disease. Studies suggest that the Mediterranean diet, (MD) traditional eating habits and lifestyle specific to the Mediterranean region, reduce the incidence of chronic diseases and improve longevity. The MD is known to be one of the healthiest diets, this diet is based on herbs, spices, vegetables, fruits, olive oils, cereals (preferably whole grains), legumes and nuts, fish and shellfish, white meat, so the main source of dietary fat from MD is olive oil. Moderate consumption of eggs and dairy products, and reduced consumption of red meats, processed meats and foods rich in sugars and fats. MD has a beneficial fatty acid profile with a higher content of monounsaturated fatty acids (MSFA) and a higher MSFA / saturated fatty acid (SFA) ratio than non-Mediterranean diets. High consumption of dietary fiber. a low glycemic index, antiinflammatory effects, and antioxidant compounds, can work together to produce favorable effects on health status. MD is rich in vitamins and minerals, such as: vitamin B (B1, B2, niacin, B6, folate and B12) and antioxidant vitamins (vitamins E and C), and polyphenol, flavonoids, phytosterols, n-fatty acids 3 (alpha linoleic acid), resveratrol, quercetin, oleic acid, carotenoids and lutein. The purpose of this review is to provide an update on the current state of science regarding the relationship between the traditional Mediterranean diet and lifestyle related chronic diseases, and discuss the mechanisms involved and opportunities. In this area of research, to clarify and increase the confidence of the role of nutrition in the etiology of chronic diseases.

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“…Adipokines that are produced by adipose tissue have extensive effects on carbohydrate and lipid metabolism and also in the pathogenesis of MetS (5). A characteristic imbalance of adipokine profile has been observed in obese subjects and/or those with MetS (6). Omentin as a new adipokine is encoded by two genes (1 and 2).…”

Section: Introductionmentioning

confidence: 99%

Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome

Goodarzi¹,

Borzuei²,

Farimani³

et al. 2014

Avicenna J Med Biochem

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Background: Adipokines that are produced by adipose tissue have extensive effects on carbohydrate and lipid metabolism and also on the pathogenesis of the metabolic syndrome (MetS). Objectives: This study aimed to measure the concentrations of omentin-1, visfatin and insulin-like growth factor-1 (IGF-1) as likely markers of metabolic syndrome and also to demonstrate their associations in women with MetS. Materials and Methods: Eighty women with MetS and eighty healthy women as controls participated in this study. Blood pressure, waist circumference, body mass index (BMI), and serum biochemical parameters were determined in all subjects. The serum level of IGF-1, omentin-1 and visfatin were assessed using the enzyme linked immunosorbent assay (ELISA). The association between omentin, visfatin and IGF-1 was also determined in these women. Results: Significantly lower levels of omentin-1 and IGF-1 were observed in MetS subjects compared to the controls (P = 0.009 and < 0.001 respectively). However, a significant difference was not observed in visfatin concentration between the two studied groups (P = 0.67). A positive association was observed between omentin-1, visfatin and IGF-1 in the MetS group. Conclusions: Our findings indicated a lower level of both omentin-1 and IGF-1 in women with MetS; this might play a role in the pathogenesis of MetS. Furthermore, the main finding of the current investigation was the association between omentin, visfatin and IGF-1; however determining the molecular mechanism of the observed relationships needs further studies.

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Adipokines as novel biomarkers and regulators of the metabolic syndrome

Cited by 482 publications

References 215 publications

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

The effects of the Mediterranean Diet on Chronic Diseases: Cardiovascular Diseases, Oxidative Stress, Dyslipidemia, Diabetes Mellitus, Blood Pressure, Cancer, Neurodegenerative Disease and Obesity

Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome

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