Adipokines and vascular health in treated HIV infection

Longenecker, Chris T.; Dunn, Whitney; Jiang, Ying; Debanne, Sara M.; McComsey, Grace A.

doi:10.1097/qad.0b013e3283606c11

Cited by 5 publications

(3 citation statements)

References 22 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, recent study demonstrated that increases in body mass index (BMI) were not related to greater risk of CVD in PLWH on cART [68]. More importantly, plasma concentrations of leptin has been shown to be higher in patient on cART and increased levels of leptin was positively correlated with FMD and negatively with cIMT [69]. In agreement with this observation, our findings established the importance of leptin signaling in the protection of vascular function and health in PLWH.…”

Section: Discussionsupporting

confidence: 88%

Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice

Kovács

Bruder‐Nascimento

Greene

et al. 2021

IJMS

View full text Add to dashboard Cite

People living with human immunodeficiency virus (HIV) (PLWH) have increased risk for atherosclerosis-related cardiovascular disease (CVD), the main cause of death in this population. Notwithstanding, the mechanisms of HIV-associated vascular pathogenesis are not fully elucidated. Therefore, we sought to determine whether HIV-regulatory protein Tat mediates HIV-induced endothelial dysfunction via NADPH oxidase 1 (Nox1)-dependent mechanisms. Body weight, fat mass, leptin levels, expression of reactive oxygen species (ROS)-producing enzymes and vascular function were assessed in C57BL/6 male mice treated with Tat for 3 days and 4 weeks. Aortic rings and human endothelial cells were also treated with Tat for 2–24 h in ex vivo and in vitro settings. Chronic (4 weeks) but not acute (3 days and 2–24 h) treatment with Tat decreased body weight, fat mass, and leptin levels and increased the expression of Nox1 and its coactivator NADPH oxidase Activator 1 (NoxA1). This was associated with impaired endothelium-dependent vasorelaxation. Importantly, specific inhibition of Nox1 with GKT771 and chronic leptin infusion restored endothelial function in Tat-treated mice. These data rule out direct effects of HIV-Tat on endothelial function and imply the contribution of reductions in adipose mass and leptin production which likely explain upregulated expression of Nox1 and NoxA1. The Nox1 and leptin system may provide potential targets to improve vascular function in HIV infection-associated CVD.

show abstract

Section: Discussionsupporting

confidence: 88%

Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice

Kovács

Bruder‐Nascimento

Greene

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…A similar effect of overweight/obese BMI on stroke risk in HIV infection was observed in the Kaiser Permanente California cohort[4]. Other studies have found a paradoxical association between higher BMI or plasma leptin, an adipokine directly correlated with fat cell mass, and lower cardiovascular risk[33–35]. The association between higher BMI and stroke risk could be confounded by overall health status, as individuals with higher BMI may be healthier and have better control of their HIV infection.…”

Section: Discussionmentioning

confidence: 52%

Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort

Chow

Wilson

et al. 2018

Aids

View full text Add to dashboard Cite

Women and non-Hispanic Blacks living with HIV had the highest incidence rates of stroke/TIA. A concerted effort must be made to include PLWH from these at-risk groups in observational and interventional studies aimed at understanding stroke mechanisms and reducing stroke risk in HIV infection. Strategies to modify stroke risk in PLWH should employ a multipronged approach targeting vascular risk factors and engaging and retaining patients in HIV care.

show abstract

“…В ряде перечисленных исследований проводилась поправка на курение как один из основных факторов сер- Более того, «парадокс ожирения», как уже говорилось, не является уникальным для сердечно-сосудистых заболеваний. Ряд исследований подтверждает положительное влияние повышенного ИМТ на выживаемость при СПИДе, терминальных стадиях хронической почечной недостаточности, что может быть частично объяснено запасом энергии в виде жира и повышенной мышечной массой в период распада белков [8,13,30].…”

Section: артериальная гипертония и ожирениеunclassified

Obesity Paradox" – another look at the problem of cardiovascular disease

Shpagina¹,

Bondarenko²

2013

Obes. metabol.

View full text Add to dashboard Cite

Major epidemiologic studies over the last century demonstrated that obesity leads to several severe diseases such as diabetes mellitus, hypertension, coronary heart disease, chronic heart failure, cerebrovascular accidents. In developed countries cardiovascular diseases became the main cause of death. In the last 5–6 years some studies showed that people with overweight and obesity of the first degree have a higher life expectancy than people with normal weight. In 2009, the published data showed that the presence of obesity in patients with chronic heart failure does not impair cardiovascular prognosis. Overweight correlates with a decrease in overall mortality by 25%. And in a first degree of obesity the risk of death is reduced by 12%. This phenomenon is called "obesity paradox" and the causes of which are discussed in this review.

show abstract

Adipokines and vascular health in treated HIV infection

Cited by 5 publications

References 22 publications

Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice

Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice

Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort

Obesity Paradox" – another look at the problem of cardiovascular disease

Contact Info

Product

Resources

About