Adipokines and the Prediction of the Accumulation of Cardiovascular Risk Factors or the Presence of Metabolic Syndrome in Elementary School Children

Yoshinaga, Masao; Sameshima, Koji; Tanaka, Yuji; Wada, Akihiro; Hashiguchi, Jun; Tahara, Hirofumi; Kono, Yukiharu

doi:10.1253/circj.cj-08-0180

Cited by 58 publications

(46 citation statements)

References 23 publications

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“…This phenomenon of leptin resistance may already be present in obese children. 20,21,114 -117,154 Children with higher leptin and lower adiponectin (discussed below) have greater CVD risk factors, regardless of weight status, 155 although not all studies support these findings. 156 Summary: Leptin has systemic effects on appetite and metabolism and is one of the most studied adipokines.…”

Section: Leptinmentioning

confidence: 99%

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal¹,

Ferranti²,

Cook³

et al. 2011

Circulation

294

239

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Abstract-The rapid increase in the prevalence and severity of obesity in children is likely to lower the age of onset and increase the incidence of cardiovascular disease worldwide. Understanding the pathophysiology and improving the clinical management of cardiovascular disease involve a knowledge of novel risk factors and biomarkers. The clinical and mechanistic roles of these novel biological factors during childhood are currently being investigated. The goals of this scientific statement are to present the existing knowledge and theoretical framework of nontraditional risk factors for cardiovascular disease as they relate to children and adolescents, to describe the relevance and weight of available experimental and clinical evidence and the therapeutic implications pertaining to nontraditional risk factors in the pediatric population, and to stimulate further research with a goal of developing valid and reliable approaches to identify and validate novel risk factors that will aid in the clinical evaluation and perhaps prediction of cardiovascular disease in the pediatric population. Although several biomarkers are promising, substantial research is required before nontraditional risk factors can be used to identify and reduce cardiovascular disease risk in children and adolescents. (Circulation. 2011;123:2749-2769.)

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Section: Leptinmentioning

confidence: 99%

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal¹,

Ferranti²,

Cook³

et al. 2011

Circulation

294

239

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“…However, the negative correlation between adiponectinemia and IR (and/or MetS) [41][42][43] has not always been observed. [44][45][46] In addition, it remains unclear whether hypoadiponectinemia is a consequence or cause of obesity, IR and MetS. 46,47 Indeed, insulin and TNF-α decrease adiponectin levels both in vitro and in vivo.…”

Section: Circulation Journal Vol73 November 2009mentioning

confidence: 99%

Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-.GAMMA. Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men Interaction With Smoking Status

Tellechea

Aranguren

Pérez

et al. 2009

Circ J

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Background:The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-γ (PPARG), has been robustly associated with type 2 diabetes. However, its role in metabolic syndrome (MetS) remains poorly understood. The associations among rs1801282, MetS and surrogate measures of insulin resistance (IR) were investigated in the present study. Methods and Results:A cross-sectional population-based survey of 572 unrelated healthy male Argentinian blood donors with normal findings on medical examination and not taking any medication was conducted. MetS was assessed using the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) criteria, and the HOMA-IR, and QUICKI were calculated. Genotyping of rs1801282 was performed using RFLP-PCR. The prevalence of MetS was 26.2%. The Pro/Ala genotype (and the Ala12 allele) was associated with a high risk for MetS (odds ratio (OR) 1.67 [95% confidence interval (CI) 1.03-2.72], P=0.0394). This was highlighted among nonsmokers (OR 2.20 [95%CI 1.25-3.88], P=0.0059). ANCOVA confirmed an interaction between smoking status and this association (P=0.031). Ala12 carriers had a higher waist circumference than noncarriers (P=0.0065). Among nonsmokers, surrogates of IR, such as HOMA-IR, were significantly higher in Ala12 carriers than in noncarriers (P<0.05). Conclusions: Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. (Circ J 2009; 73: 2118 -2124

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“…Furthermore, studies show that circulating CRP in children is positively associated with individual components of metabolic syndrome and clustered cardiovascular disease (CVD) risk score (Andersen et al, 2010;Cook et al, 2000). In children, high leptin and low adiponectin levels are also found to be predictive of the accumulation of CVD risk factors (Yoshinaga et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial

Huang

Larsen

Møller

et al. 2015

Preventive Medicine

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This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Huang, T., Larsen, K. T., Møller, N. C., Ried-Larsen, M., Frandsen, U., Andersen, L. B. (2015 Methods:One hundred and fifteen children were recruited in Odense, Denmark (2011Denmark ( -2014. The participants were randomly allocated to either the day camp intervention arm (DCIA) or the standard intervention arm (SIA). The intervention for the DCIA comprised a 6-week camp intervention and a 46-week family-based intervention. The SIA was offered one weekly physical activity session for 6 weeks and one educational meeting. C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured in serum at baseline, 6 weeks and 52 weeks.Results: Compared with the SIA, the reductions in CRP (P=0.003) and leptin (p<0.001) were larger in the DCIA at 6 weeks. The intervention effects on leptin were significantly mediated by the changes in body fat mass. No intervention effects on CRP and leptin were seen at 52 weeks. No between-group differences in changes in MCP1 and adiponectin were observed at 6 weeks or 52 weeks. Conclusions:The 6-week camp intervention resulted in reductions in CRP and leptin. The intervention effects did not persist to 52 weeks. The intervention effect on leptin was explained by the changes in body fat mass.

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Adipokines and the Prediction of the Accumulation of Cardiovascular Risk Factors or the Presence of Metabolic Syndrome in Elementary School Children

Cited by 58 publications

References 23 publications

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-.GAMMA. Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men Interaction With Smoking Status

Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial

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