Adipokines and incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis

Broni, Eric K; Ogunmoroti, Oluseye; Quispe, Renato; Sweeney, Ty; Varma, Bhavya; Fashanu, Oluwaseun E.; Lutsey, Pamela L; Allison, Matthew; Szklo, Moysés; Ndumele, Chiadi E; Michos, Erin D.

doi:10.1016/j.jtha.2022.11.012

Cited by 4 publications

(1 citation statement)

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“…The primary independent variables were levels of the endogenous adipokines (leptin, adiponectin, and resistin) and their ratios (leptin/adiponectin and resistin/adiponectin). Samples of fasting serum were obtained at either visit 2 (2002-2004) or visit 3 (2004-2005), at the visit of the abdominal CT scan, [22][23][24] and immediately frozen at -70 o C. In 2009, the adipokines (adiponectin, leptin, and resistin) were measured from these stored serum samples using a Bio-Rad Luminex All rights reserved. No reuse allowed without permission.…”

Section: Independent Variables Assessmentmentioning

confidence: 99%

Associations of Adipokine Levels with Levels of Remnant Cholesterol: the Multi-Ethnic Study of Atherosclerosis (MESA)

Quispe

Sweeney

Martin

et al. 2023

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Background The metabolic syndrome phenotype of individuals with obesity is characterized by elevated levels of triglyceride (TG)-rich lipoproteins and remnant particles, which have been shown to be significantly atherogenic. Understanding the association between adipokines, endogenous hormones produced by adipose tissue, and remnant cholesterol (RC) would give insight into the link between obesity and atherosclerotic cardiovascular disease. Methods We studied 1,791 MESA participants of an ancillary study on body composition who had adipokine levels measured (leptin, adiponectin, resistin) at either visit 2 or 3. RC was calculated as non-high density lipoprotein cholesterol minus low-density lipoprotein cholesterol (LDL-C), measured at the same visit as the adipokines, as well as subsequent visits 4 through 6. Multivariable-adjusted linear mixed effects models were used to assess the cross-sectional and longitudinal associations between adipokines and levels of RC. Results Mean (SD) age was 64.5{plus minus}9.6 years and for body mass index (BMI) was 29.9{plus minus}5.0 kg/m2; 52.0% were women. In fully adjusted models that included BMI, LDL-C and lipid-lowering therapy, for each 1-unit increment in adiponectin, there was 14.4% (12.0, 16.8) lower RC. With each 1-unit increment in leptin and resistin, there was 4.5% (2.3, 6.6) and 5.1% (1.2, 9.2) higher RC, respectively. Lower adiponectin and higher leptin were also associated with longitudinal increases in RC levels over median follow-up of 5(4-8) years. Conclusions Lower adiponectin and higher leptin levels were independently associated with higher levels of RC at baseline and longitudinal RC increase, even after accounting for BMI and LDL-C.

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Section: Independent Variables Assessmentmentioning

confidence: 99%