Adipokine Serum Levels Are Related to Liver Histology in Severely Obese Patients Undergoing Bariatric Surgery

Αργέντου, Μαρία-Ιωάννα; Tiniakos, Dina; Καρανικόλας, Μενέλαος; Melachrinou, Maria; Makri, Maria; Kittas, Christos; Kalfarentzos, Fotis

doi:10.1007/s11695-009-9912-9

Cited by 39 publications

(33 citation statements)

References 59 publications

(87 reference statements)

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“…Adipokines have been shown to be related to liver pathology and also in morbid obesity (15). Chemerin levels are significantly elevated in morbidly obese women characterized by a significant activity score for nonalcoholic fatty liver disease and fibroinflammation.…”

Section: Discussionmentioning

confidence: 99%

Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery

Sell

Divoux

Poitou

et al. 2010

The Journal of Clinical Endocrinology &Amp; Metabolism

230

195

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Context: Chemerin is a new adipokine involved in in vitro adipogenesis and insulin resistance and associates with body mass index (BMI) in vivo.Objective: We investigated the role of chemerin in morbid obesity, associated metabolic diseases (insulin resistance, hepatic diseases), and postsurgery-induced weight loss. Setting:This was a prospective study performed at a university hospital.Subjects: Subjects included 60 obese female patients (BMI 50.0 Ϯ 1.0 kg/m Ϫ2 ) being candidates for gastric bypass.Study Design: Patients were examined before and 3, 6, and 12 months after surgery. In 27 patients, chemerin was measured after 2 yr.Main Outcome: Outcomes included chemerin, anthropometric parameters, homeostasis model assessment for insulin resistance index (HOMA-IR), cholesterol, high-density lipoprotein, triglycerides, C-reactive protein, adipokines at all time points; and liver histology and macrophage content in fat at baseline. Results:Chemerin was substantially elevated in obese patients compared with nonobese persons (353.8 Ϯ 18.0 vs. 191 Ϯ 14 ng/ml, P Ͻ 0.001). Preoperatively, chemerin concentrations correlated positively with BMI, C-reactive protein, IL-6, HOMA-IR, and the amount of omental macrophages and negatively with high-density lipoprotein levels. Baseline chemerin was elevated in patients with a significant activity score for nonalcoholic fatty liver disease, portal inflammation, fibrosis, and fibroinflammation. After surgery, chemerin decreased significantly to 253.0 Ϯ 14.9 ng/ml after 1 yr and pursued its decrease in patients studied for 2 yr. After surgery, chemerin concentrations positively correlated with triglycerides. The strong decrease of chemerin in the 3 months after surgery was associated with the decrease in HOMA-IR and blood glucose. Conclusions:Chemerin concentrations are elevated in morbidly obese patients and correlated with insulin resistance and markers of liver pathology. Chemerin plasma concentrations decreased after bariatric surgery. This study suggests that chemerin might mediate metabolic alterations in obesity, drastically improving after gastric bypass. O besity is one of the most serious health hazards and frequently accompanied by metabolic disturbances (1). Increased adipose tissue mass, especially in the visceral compartment, is characterized by altered metabolic and endocrine function leading to an increased secretion of proinflammatory adipokines. These secreted molecules may be factors underlying the association between increased body fat and metabolic complications such as insulin resistance in peripheral organs or ectopic fat accumulation. Chemerin is a recently described adipokine

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Section: Discussionmentioning

confidence: 99%

Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery

Sell

Divoux

Poitou

et al. 2010

The Journal of Clinical Endocrinology &Amp; Metabolism

230

195

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“…Additionally, a recent study showed lower levels of resistin in NASH patients compared with those with simple steatosis [149]. In other studies no differences in resistin concentrations were found between NAFLD patients and matched controls [150][151][152].…”

Section: Resistinmentioning

confidence: 99%

Role of Adipocytokines in Hepatic Fibrosis

Bertolani¹,

Marra²

2010

CPD

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Hepatic fibrosis is a dynamic process whereby the liver responds to conditions of persistent damage. This leads to deposition of fibrillar extracellular matrix, altered hepatocyte regeneration, deranged microvascular architecture and cirrhosis. Accumulating data demonstrate that obesity and insulin resistance are associated with a more severe and faster progression of the fibrogenic process indifferent chronic liver diseases, and attention has focused on possible links between the adipose tissue and liver repair.ADIPOCYTOKINEs are cytokines secreted primarily by adipose tissue, they are relevant for adipose tissue physiology and metabolism.Alterations in the adipocytokine pattern are involved in different obesity-related diseases, such as hypertension, atherosclerosis and type II diabetes mellitus (T2DM).Numerous recent studies have analyzed the role played by adipocytokines in the process of hepatic 'wound healing' and fibrogenesis. In particular, data have accumulated on the role of adiponectin and leptin. This review summarizes the more significant and recent findings concerning the role played by different adipocytokines in hepatic fibrogenesis, discussing the actions of adipocytokines on the biology of liver cells, and their effects in different animal models. The variations in the circulating levels and intrahepatic expression of different adipocytokines in patients with fibrogenic liver diseases are also discussed.

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“…Even further upstream of this are endocrine and paracrine mechanisms that can promote lipogenesis. Adiponectin is a key insulin sensitizer, which is often decreased in insulin resistant states [9]. Adiponectin is an adipokine and a PPAR-target.…”

Section: Systemic Metabolic Disturbances That Contribute To Steatohepmentioning

confidence: 99%

Novel therapeutic targets for steatohepatitis

Sanyal

2015

Clinics and Research in Hepatology and Gastroenterology

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Adipokine Serum Levels Are Related to Liver Histology in Severely Obese Patients Undergoing Bariatric Surgery

Cited by 39 publications

References 59 publications

Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery

Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery

Role of Adipocytokines in Hepatic Fibrosis

Novel therapeutic targets for steatohepatitis

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