“…However, detailed roles of BMP-6 and OPN have not yet been decided. To know their roles in renal fibrogenesis, we investigated their expression patterns in cisplatin (CDDP; cis-diamminedichloroplatinum II)-induced renal fibrosis in rats in vivo (Yamamoto et al, 2012) of BMP-6 and OPN in modulating fibrogenic factors was analyzed by using kidney-constituting cell lines in vitro: renal interstitial fibroblastic cell line (NRK-49F), renal tubular epithelial cell line (NRK-52E), and immature mesenchymal cell line (MT-9) resembling pericytes (Yamate et al, 2007). The present study shows the participation of BMP-6 and OPN in the CDDP-induced renal fibrosis, in close association with TGF-1.…”