Adipogenesis inhibitory factor A novel inhibitory regulator of adipose conversion in bone marrow

Ohsumi, Jun; Miyadai, Kenji; Kawashima, Ichiro; Ishikawa-Ohsumi, Hiroko; Sakakibara, Satoshi; Mita-Honjo, Katsuko; Takiguchi, Yo

doi:10.1016/0014-5793(91)80991-b

Cited by 41 publications

(15 citation statements)

References 12 publications

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“…Subsequent analyses revealed that IL-11 could inhibit adipogenesis of 3T3-L1 preadipocytes and suppress lipoprotein lipase activity in fully differentiated murine adipocytes [106; 107]. Several additional studies document the ability of IL-11 to inhibit adipocyte differentiation, as well as the expression of adipogenic markers [28; 29; 108; 109].…”

Section: Interleukin-11mentioning

confidence: 99%

The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

White¹,

Stephens²

2011

Current Pharmaceutical Design

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Gp130 cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. These cytokines share glycoprotein 130 as a common signal transducer in their receptor complex and typically activate STAT3. Most gp130 cytokines have paracrine or endocrine actions, and their levels can be measured in circulation in rodents and humans. In recent years, various laboratories have conducted studies to demonstrate that gp130 cytokines can modulate adipocyte development and function. Therefore, these studies suggest that some gp130 cytokines may be viable anti-obesity therapeutics. In this review, we will summarize the reported effects of gp130 cytokines on adipocyte differentiation and adipocyte function. In addition, the modulation of gp130 cytokines in conditions of obesity, insulin resistance, and Type 2 diabetes will be presented.

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Section: Interleukin-11mentioning

confidence: 99%

The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

White¹,

Stephens²

2011

Current Pharmaceutical Design

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“…Our laboratory has previously shown that IL-11 stimulates multilineage hematopoietic reconstitution and the recovery of intestinal epithelial cells after cytoablative cancer therapies (Du et al, , 1994Maze et al, 1994). IL-11 has also been demonstrated t o affect the differentiation of a murine hippocampal progenitor cell line (Mehler et al, 1993) and alter the phenotype of cultured sympathetic neurons (Fann and Patterson, 1994), inhibit adipogenesis (Kawashima et al, 1991;Ohsumi et al, 1991;Keller et al, 1993) mediate the 0 1996 WILEY-LISS, INC acute phase response of the hepatocytes (Fukuda and Sassa, 1993;Baumann and Schendel, 19911, and mediate metabolism of extracellular matrix (ECM) (Maier et al, 1993;Roeb et al, 1993).…”

mentioning

confidence: 96%

Murine interleukin-11 (IL-11) is expressed at high levels in the hippocampus and expression is developmentally regulated in the testis

Everett

Wang

et al. 1996

J. Cell. Physiol.

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IL-11, derived from a bone marrow stromal cell line, has pleiotropic effects on both hematopoietic cells and nonhematopoietic cells. However, no previous studies have systematically addressed expression of IL-11 in primary tissues in vivo and the relationship of IL-11 tissue specific gene expression and function of IL-11 is not clear. In the present study, we examined constitutive IL-11 expression in various murine adult tissues in vivo. IL-11 mRNA is expressed in a wide range of normal tissues (including hematopoietic organs) at levels only detected by RT-PCR. IL-11 protein was detected in brain and testis by Western blot analysis. The in vivo cellular distribution of IL-11 expression was examined by in situ hybridization. In brain, IL-11 message is distributed in granular layer dentate gyrus and pyramidal cell layers of hippocampus. IL-11 is also expressed in anterior horn cells and lateral column neuronal cells of the spinal cord. In testis, IL-11 mRNA is expressed in round spermatids at stage VI-IX seminiferous tubules. IL-11 expression in testis is restricted to developing spermatogonia and is developmentally regulated, since no expression is seen in mice genetically deficient in germ cells and in mice prior to sexual maturation. These expression data correlate with functional data demonstrating that IL-11 stimulates proliferation in vitro of a hippocampus neuronal progenitor cell line and administration of IL-11 in vivo accelerates recovery of spermatogenesis after cytotoxic therapy. These studies suggest that IL-11 may be an important regulator in neural and testicular function.

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“…Growth factors like EGF and platelet-derived growth factor (6) or cytokines, such as interleukin-11 (7)(8)(9), tumor necrosis factor-␣ (10,11), and transforming growth factor-␤ (11)(12)(13), can inhibit adipogenesis and cause reversal of the adipocyte phenotype. In addition, growth hormone has been shown to inhibit differentiation of primary preadipocytes (6), but it exerts a proadipogenic action on several preadipocyte cell lines, including 3T3-L1 (14 -16).…”

mentioning

confidence: 99%

Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation

Zhang

Nøhr

Jensen

et al. 2003

Journal of Biological Chemistry

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Pref-1 is a highly glycosylated Delta-like transmembrane protein containing six epidermal growth factorlike repeats in the extracellular domain. Pref-1 is abundantly expressed in preadipocytes, but expression is down-regulated during adipocyte differentiation. Forced expression of Pref-1 in 3T3-L1 cells was reported to inhibit adipocyte differentiation. Here we show that efficient and regulated processing of Pref-1 occurs in 3T3-L1 preadipocytes releasing most of the extracellular domain as a 50-kDa heterogeneous protein, previously isolated and characterized as FA1. Unexpectedly, we found that forced expression of the soluble form, FA1, or full-length Pref-1 did not inhibit adipocyte differentiation of 3T3-L1 cells when differentiation was induced by standard treatment with methylisobutylxanthine, dexamethasone, and high concentrations of insulin. However, forced expression of either form of Pref-1/FA1 in 3T3-L1 or 3T3-F442A cells inhibited adipocyte differentiation when insulin or insulin-like growth factor-1 (IGF-1) was omitted from the differentiation mixture. We demonstrate that the level of the mature form of the IGF-1 receptor is reduced and that IGF-1-dependent activation of p42/p44 mitogen-activated protein kinases (MAPKs) is compromised in preadipocytes with forced expression of Pref-1. This is accompanied by suppression of clonal expansion and terminal differentiation. Accordingly, supplementation with insulin or IGF-1 rescued p42/p44 MAPK activation, clonal expansion, and adipocyte differentiation in a dose-dependent manner.

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Adipogenesis inhibitory factor A novel inhibitory regulator of adipose conversion in bone marrow

Cited by 41 publications

References 12 publications

The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

Murine interleukin-11 (IL-11) is expressed at high levels in the hippocampus and expression is developmentally regulated in the testis

Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation

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