Adipocytokines and Lipid Levels in Ames Dwarf and Calorie-Restricted Mice

Wang, Zhihui; Al-Regaiey, Khalid; Masternak, Michał M.; Bartke, Andrzej

doi:10.1093/gerona/61.4.323

Cited by 95 publications

(75 citation statements)

References 30 publications

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“…Furthermore, adiponectin levels correlate with the delayed aging and enhanced insulin sensitivity. For example, an increase in adiponectin has been well established in long-lived mice such as Ames dwarf (Wang et al 2006), Snell dwarf (Brooks et al 2007), and GHR-KO (Berryman et al 2011) mice, and adiponectin is more abundant in plasma of human subjects without metabolic syndrome (Bik and Baranowska 2009;Coppack 2005). Here, we show that HFHS diet suppresses adiponectin levels in N mice, but PAPP-A KO mice are completely protected from this effect.…”

Section: Discussionsupporting

confidence: 46%

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

Hill

Arum

Boparai

et al. 2015

AGE

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Longevity and aging are influenced by common intracellular signals of the insulin/insulin-like growth factor (IGF)-1 pathway. Abnormally high levels of bioactive IGF-1 increase the development of various cancers and may contribute to metabolic diseases such as insulin resistance. Enhanced availability of IGF-1 is promoted by cleavage of IGF binding proteins (IGFBPs) by proteases, including the pregnancyassociated plasma protein-A (PAPPA). In vitro, PAPP-A is regulated by pro-inflammatory cytokines (PICs) such as interleukin (IL)-6 and tumor necrosis factor (TNF). Mice born with deficiency of the Papp-a gene (PAPP-A knockout (KO) mice) live ∼30-40 % longer than their normal littermates and have decreased bioactive IGF-1 on standard diets. Our objective was to elucidate how the effects of high-fat, high-sucrose diet (HFHS) promote obesity, induce metabolic dysfunction, and alter systemic cytokine expression in PAPP-A KO and normal mice. PAPP-A KO mice fed HFHS diet for 10 weeks were more glucose tolerant and had enhanced insulin sensitivity compared to normal mice fed HFHS diet. PAPP-A KO mice fed HFHS diet had lower levels of pro-inflammatory cytokines (IL-2, IL-6, and TNF-α) compared to normal mice fed the same diet. However, anti-inflammatory cytokine levels (IL-4 and adiponectin) were higher in PAPP-A KO mice fed AGE (2015) 37: 51

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Section: Discussionsupporting

confidence: 46%

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

Hill

Arum

Boparai

et al. 2015

AGE

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“…They exhibit deficiencies in growth hormone, prolactin, and thyroid-stimulating hormone as well as a smaller body size with normal or reduced fat mass 13) . Ames dwarf mice also display enhanced insulin sensitivity, which is closely associated with high adiponectin levels in plasma 14) . In addition, mice with fat-specific disruption of the insulin receptor gene (FIRKO mice) are reported to have decreased adiposity, lower fasting insulin levels, and an extended lifespan 5) .…”

Section: Experimental Evidence Linking Adipokines Insulin Sensitivitmentioning

confidence: 99%

Adipokines and Aging

Arai

Takayama

Abe

et al. 2011

JAT

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Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystrophic syndromes and Hutchinson-Gilford progeria syndrome, both of which are caused by mutations in the LMNA gene, loss of adipose tissue is associated with adipokine dysregulation, insulin resistance, and atherosclerosis, suggesting a critical role of adipose tissue function in controlling whole body energy metabolism, age-related pathologies, and longevity. Centenarians, a model of healthy aging and longevity, are reported to exhibit preserved insulin sensitivity as well as favorable adipokine profiles, particularly high levels of circulating adiponectin. Furthermore, adipose tissue dysfunction indicated by dysregulation of leptin, tumor necrosis factor-, and adiponectin is associated with poor prognosis in centenarians. In contrast to results obtained for obesity, adipokine dysregulation in centenarians is associated with very low leptin levels, suggesting that age-related lipoatrophy is the major factor for adipose tissue dysfunction at an advanced age. These observations suggest that adipose tissue excess as well as its aging is implicated in the regulation of adipokines, insulin sensitivity, and lifespan in humans.J Atheroscler Thromb, 2011; 18:545-550.

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“…Fatty acid synthesis is also augmented after short-term CR in rats (11). With regard to adipokines, circulating adiponectin levels are reported to increase in response to CR (12,13).…”

mentioning

confidence: 99%

Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice

Varady

Roohk

Loe

et al. 2007

Journal of Lipid Research

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Calorie restriction (CR) affects adipocyte function and reduces body weight. However, the effects of alternateday fasting (ADF) on adipose biology remain unclear. This study examined the effects of ADF and modified ADF regimens on adipocyte size, triglyceride (TG) metabolism, and adiponectin levels in relation to changes in body weight and adipose mass. Twenty-four male C57BL/6J mice were randomized for 4 weeks among 1) ADF-25% (25% CR on fast day, ad libitum on alternate day), 2) ADF-50% (50% CR on fast day), 3) ADF-100% (100% CR on fast day), and 4) control (ad libitum). The body weight of ADF-100% mice was lower than that of the other groups (P , 0.005) after treatment. Adipose tissue weights did not change. Inguinal and epididymal fat cells were 35-50% smaller (P , 0.01) than those of controls in ADF-50% and ADF-100% animals after treatment. Net lipolysis was augmented (P , 0.05) in ADF-100% mice, and the contribution from glyceroneogenesis to a-glycerol phosphate increased in ADF-50% and ADF-100% mice, whereas fractional and absolute de novo lipogenesis also increased in ADF-50% and ADF-100% animals, consistent with an alternating feast-fast milieu. Plasma adiponectin levels were not affected. In summary, modified ADF (ADF-50%) and complete ADF (ADF-100%) regimens modulate adipocyte function, despite there being no change in body weight or adipose tissue weight in the former

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Adipocytokines and Lipid Levels in Ames Dwarf and Calorie-Restricted Mice

Cited by 95 publications

References 30 publications

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

Adipokines and Aging

Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice

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