Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery

Laurikka, Antti; Vuolteenaho, Katriina; Toikkanen, Vesa; Rinne, Timo; Leppänen, Tiina; Tarkka, Matti; Laurikka, Jari; Moilanen, Eeva

doi:10.1093/ejcts/ezt634

Cited by 31 publications

(22 citation statements)

References 25 publications

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“…the resistin plasma levels in the patients with ACS were significantly elevated within the first week after the onset of symptoms and correlated positively with the levels of plasma myocardium injury markers and negatively with LVEF [37]. In patients undergoing cardiothoracic surgery, the levels of resistin were correlated with oxidative stress and myocardial injury [38]. In a recently published paper, resistin was considered to be an independent risk factor of recurrent AMI/unstable angina among patients with coronary artery disease [39].…”

Section: Discussionmentioning

confidence: 99%

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome

Michalski

Szymczyk

Pęczek

et al. 2017

aoms

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IntroductionThe aim of this study was to evaluate the predictive value of selected adipokines in the improvement in the ejection fraction and in the development of adverse cardiac remodeling during 12 months of follow-up among patients with an ST-segment elevation acute myocardial infarction (STEMI) in the presence of metabolic syndrome (MeS).Material and methodsThe study population consisted of 69 patients (49 male; mean age: 59 ±10 years) with a first STEMI that was treated with a primary percutaneous coronary intervention (pPCI). In this group, 36 patients (18 male; mean age: 60 ±15 years) had MeS according to the definition of the International Diabetes Federation. The baseline clinical evaluation included a clinical examination and evaluation of the blood levels of C-reactive protein, ghrelin, resistin, and fasting glucose. Within 72 h after the STEMI, an echocardiographic examination was performed. A complete clinical evaluation was repeated after 12 months. Adverse cardiac remodeling was defined as an increase in the left ventricular end-diastolic volume of ≥ 8%. An improvement of the ejection fraction (EF) was defined as an increase of more than 5% in the EF.ResultsA concentration of ghrelin ≤ 160.46 pg/ml (AUC = 0.71, p = 0.032) had a good predictive value for the occurrence of adverse left ventricular remodeling but only in the patients without MeS. Among the patients with MeS, a concentration of resistin ≤ 5196 pg/ml (AUC = 0.073, p = 0.024) had a good predictive value for the occurrence of left ventricular remodeling. A concentration of leptin > 52.18 pg/ml (AUC = 0.81, p < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, p = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS.ConclusionsThe selected adipokines had a good predictive value for the development of adverse cardiac remodeling and for improvement of the ejection fraction among patients after a STEMI in the presence of metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome

Michalski

Szymczyk

Pęczek

et al. 2017

aoms

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“…Circulating resistin levels have been shown to be upregulated in inflammatory bowel diseases [32], chronic kidney disease [33] and in asthma [34]. Resistin has been proposed as a biomarker for steroid-sensitive asthma [35] and as a predictive marker for the degree of ischemia-reperfusion injury during cardiac surgery [36].…”

Section: Discussionmentioning

confidence: 99%

Resistin and interleukin 6 as predictive factors for recurrence and long-term prognosis in renal cell cancer

Kallio

Hämäläinen

Luukkaala

et al. 2017

Urologic Oncology: Seminars and Original Investigations

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“…A resistin concentration equal to or above 17.3 ng/ml is associated with a 13-fold increase in the risk of major cardiac and cerebrovascular events in patients with multivessel coronary disease (Table IV) [82]. Resistin levels also rise 24 h after CABG as a marker of ischemia-reperfusion injury and are correlated with oxidative stress [83]. However, resistin levels do not seem to change after 12 months of medical treatment or CABG in these patients and thus may not be helpful for follow-up after therapeutic intervention [69].…”

Section: Resistinmentioning

confidence: 99%

“…Resistin levels correlate with troponin 24 h after CABG, reflecting myocardial injury [83]. Resistin levels are also significantly increased in AMI and unstable and stable angina patients, with resistin being significantly higher in AMI than in unstable/stable angina.…”

Section: Resistinmentioning

confidence: 99%

Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3

Hogaş¹,

Bîlha²,

Brănișteanu³

et al. 2017

aoms

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Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have significantly improved the assessment of major cardiovascular events and diseases but cannot be applied to all patients and in some cases do not provide sufficiently accurate information. In this context, new potential biomarkers that reflect various underlying pathophysiological cardiac and vascular modifications are needed. Also, a multiple biomarker evaluation that shows changes in the cardiovascular state is of interest. This review describes the role of selected markers of vascular inflammation, atherosclerosis, atherothrombosis, endothelial dysfunction and cardiovascular fibrosis in the pathogenesis and prognosis of cardiovascular disease: the potential use of cardiotrophin-1, leptin, adiponectin, resistin and galectin-3 as biomarkers for various cardiovascular conditions is discussed.

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Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery

Cited by 31 publications

References 25 publications

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome

Resistin and interleukin 6 as predictive factors for recurrence and long-term prognosis in renal cell cancer

Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3

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