Adipocytokine and ghrelin levels in relation to bone mineral density in prepubertal rhythmic gymnasts entering puberty: a 3-year follow-up study

Võsoberg, Kristel; Tillmann, Vallo; Tamm, Anna-Liisa; Jürimäe, Toivo; Maasalu, Katre; Jürimäe, Jaak

doi:10.1007/s00421-016-3338-6

Cited by 4 publications

(8 citation statements)

References 40 publications

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“…The effects of resistin and other adipokines are still under study. While only a few cross-sectional studies have focused on the association between serum adipokines and bone turnover/remodeling in humans, many clinical studies have questioned the association between serum adiponkines levels and bone mineral density (BMD) 11–13…”

Section: Introductionmentioning

confidence: 99%

<p>Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD</p>

Azizieh¹,

Shehab²,

Jarallah³

et al. 2019

JIR

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Objective: In addition to some well-characterized bone turnover markers (BTMs), cytokines and adipokines have also been suggested to be linked to osteoporosis seen in menopause. However, there is much controversy on the possible association between these markers and bone mineral density (BMD). This study was aimed at measuring circulatory levels of selected cytokines, adipokines and BTMs in postmenopausal women with normal and low BMD. Methods: The study population included 71 post-menopausal women, of whom 25 had normal BMD, 31 had osteopenia and 13 had osteoporosis. Circulatory levels of selected pro-resorptive (TNF-α, IL-1β, IL-6, IL-8, IL-12, IL-17), anti-resorptive (IFN-γ, IL-4, IL-10, IL-13, TGF-β) and five adipokine markers (adiponectin, adipsin, lipocalin-2/NGAL, PAI-1 and resistin) were measured using the Multiplex system and read on the Magpix ELISA platform. Further, two bone turnover markers (PINP, CTX) as well as estradiol levels were assayed from the same samples. Results: While circulatory levels of cytokines were comparable between groups, women with low BMD had statistically significantly higher median circulatory levels of adipokines as compared to those with normal BMD. Further, while levels of CTX were not different between the two groups; PINP, PINP/CTX ratio and estradiol levels were significantly lower in women with low BMD. Levels of adiponectin, PINP, PINP/CTX ratio and estradiol correlated significantly with BMD of the hip and spine. Conclusion: The associations between various markers and BMD are complex and multivariate. Our data provide insights into the possible use of circulatory levels of cytokines, adipokines and bone turnover markers on the pathogenesis of postmenopausal osteoporosis because of the well-documented effects of these molecules on bone tissue and their relevance to osteoporosis.

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Section: Introductionmentioning

confidence: 99%

<p>Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD</p>

Azizieh¹,

Shehab²,

Jarallah³

et al. 2019

JIR

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“…Whole body (WB), femoral neck (FN) and lumbar spine (LS) bone mineral content (BMC, in g) were measured by dual-energy x-ray absorptiometry (DXA) using the DPX-IQ densitometer (Lunar Corporation, Madison, WI, USA) equipped with proprietary software, version 3.6. Data for different aBMD values for this cohort have been previously published (Võsoberg et al, 2016(Võsoberg et al, , 2017. In addition, WB fat mass (FM, in kg) and fat free mass (FFM, in kg) were also determined.…”

Section: Bone Mineral Content and Body Compositionmentioning

confidence: 99%

“…To reduce the impact of the operator variability factor, the same qualified examiner analyzed all scans over the 3-year period. The precision of measurement expressed as coefficient of variation (CV%) was less than 2% for all bone mineral and body composition measurements (Võsoberg et al, 2016(Võsoberg et al, , 2017.…”

Section: Bone Mineral Content and Body Compositionmentioning

confidence: 99%

“…Venous blood samples were taken between 7:30 and 8:30 a.m. after an overnight fast from an antecubital vein with the participant sitting in the upright position. Samples from one individual were run in the same assay (Võsoberg et al, 2016). Leptin concentration was determined by radioimmunoassay (RIA) (Mediagnost GmbH, Reutlingen, Germany).…”

Section: Blood Analysismentioning

confidence: 99%

“…There are substantial data to suggest that body fat mass (FM) and fat free mass (FFM) are both positively associated with bone mineral accrual during puberty in girls with different training patterns (Gruodyte et al, 2010; Research article Jürimäe et al, 2021). A positive influence of FM on bone mineral accrual has been attributed to a mechanical loading (Jürimäe et al, 2018) and the impact of hormones linked to adipose tissue (Jürimäe, 2014), including leptin and adiponectin (Gruodyte et al, 2010;Võsoberg et al, 2016). Previously, leptin (Muñoz et al, 2004) and adiponectin (Gruodyte et al, 2010) have been linked to aBMD and BMC values at various skeletal sites, while other studies have not found relationships between these adipokine values and bone mineral accrual in adolescent female athletes with different training patterns (Maimoun et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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A Longitudinal Study of Bone Mineral Accrual during Growth in Competitive Premenarcheal Rhythmic Gymnasts

Remmel¹,

Tillmann²,

Tamm³

et al. 2021

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The purpose of this investigation was to study whether prolonged competitive rhythmic gymnastics training influenced bone mineral accrual in premenarcheal girls. Eighty-nine girls (45 rhythmic gymnasts [RG] and 44 untrained controls [UC]) between 7 and 9 years of age were recruited and measured annually for four years (not all participants were measured at every occasion). Dual energy x-ray absorptiometry was used to assess the development of whole body (WB), femoral neck (FN) and lumbar spine (LS) bone mineral content (BMC). In addition, body composition, blood adipokine and jumping performance characteristics were obtained. For longitudinal analyses, hierarchical mixed-effects models were constructed to predict differences in the development of WB, FN and LS BMC between RG and UC groups, while accounting for differences in body composition, blood adipokine and jumping performance values. It appeared that from 8 years of age, RG had lower (p < 0.05) fat mass and leptin values, and higher (p < 0.05) jumping performance measures in comparison with UC girls. Hierarchical mixed-effects models demonstrated that RG had 71.9 ± 12.0, 0.23 ± 0.11 and 1.39 ± 0.42 g more (p < 0.05) WB, FN and LS BMC, respectively, in comparison with UC girls. In addition, WB, FN and LS BMC increased more (p < 0.05) between 7 to 12 years of age in RG girls in comparison with UC. In conclusion, these findings suggest that the prolonged exposure to competitive rhythmic gymnastics trainings in premenarcheal girls is associated with greater bone mineral accrual despite lower body fat mass and leptin values.

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Bone Health Considerations for the Adolescent Female Athlete

2018

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Adipocytokine and ghrelin levels in relation to bone mineral density in prepubertal rhythmic gymnasts entering puberty: a 3-year follow-up study

Cited by 4 publications

References 40 publications

<p>Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD</p>

<p>Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD</p>

A Longitudinal Study of Bone Mineral Accrual during Growth in Competitive Premenarcheal Rhythmic Gymnasts

Bone Health Considerations for the Adolescent Female Athlete

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