“…The HIF signal pathway is the main substrate for PHD2 to perform its regulatory role. At present, in reports signed by Michailidou and Matsuura, adipose-selective PHD2 knockout in whole body elevated the BAT function and energy consumption enhancement of mice through activation of the HIFα signal pathway which is distinct from our research [ 73 , 74 ]. Actually, the effects of HIFα on adipose are complex and miscellaneous.…”