Adipocyte metabolism and the metabolic syndrome

Stears, Anna; Byrne, Christopher D.

doi:10.1046/j.1463-1326.2001.00151.x

Cited by 27 publications

(12 citation statements)

References 137 publications

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“…Many adipocytokines may regulate insulin sensitivity, inflammation, and metabolism [3]. Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a new adipocytokine [4].…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

et al. 2011

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Background: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine. Several studies have indicated that vaspin may exert an important role in the development of metabolic disorders. Objective: Evaluate serum vaspin and its relation to clinical parameters in newly and previously diagnosed Chinese type 2 diabetes mellitus (T2DM) females as a case-control study. Materials and methods: One hundred twenty female participants (newly and previously diagnosed T2DM patients) were recruited from an affiliated hospital of Harbin Medical University. Sixty healthy female volunteers from various communities were included as controls. Anthropometric parameters, serum fasting blood glucose, fasting insulin, lipid profile, HbA1c, and vaspin were measured in each participant. Results: Serum vaspin levels were significantly lower in previously diagnosed T2DM patients (0.51±0.29 ng/mL) than in newly diagnosed T2DM patients (0.62±0.28 ng/mL) and healthy controls (0.69±0.31 ng/mL). However, there was no difference in serum vaspin between newly diagnosed T2DM patients and healthy controls. In multiple linear regression analysis, serum vaspin was significantly and positively associated with HbA1c in both newly and previously diagnosed T2DM patients, negatively associated with homeostasis model assessment of insulin resistance in previously diagnosed patients, and positively correlated with age and body mass index in healthy controls. Conclusion: Serum vaspin was significantly lower in previously diagnosed T2DM patients than in newly diagnosed T2DM patients and healthy controls. Serum vaspin might be a predictor of poor glucose control and insulin resistance in T2DM.

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Section: Brief Communication (Original)mentioning

confidence: 99%

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

et al. 2011

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“…Depending on anatomical location, mainly with regard to subcutaneous vs visceral depots, distinct physiological properties have been reported [59][60][61][62][63]. More precisely, differences in protein production, metabolic activity and response to hormones between WAT depots have been described [58,61,[63][64][65]. Lipodystrophies are characterized by selective loss of fat from part of the body [66], that can be for example restricted to subcutaneous WAT but also extended to nearly the whole body fat.…”

Section: Wat Locationmentioning

confidence: 99%

“…Considerable differences in gene expression and secretion of adipose-derived factors have been found according to adipose location [58,63,65,[70][71][72][73][74] and fat cell size [4]. In the fed state, adiponectin, resistin, adiponutrin, plasminogen activator inhibitor 1 (PAI-1), and interleukin 6 (IL-6) are expressed at higher levels in visceral than in subcutaneous adipocytes of humans and/or rodents [25,[75][76][77].…”

Section: Wat Locationmentioning

confidence: 99%

Adipose-Derived Factors During Nutritional Transitions

Bertile¹,

Raclot²

2006

CNF

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It is now commonly accepted that white adipocytes actively secrete a wide range of bioactive molecules including leptin, adiponectin, resistin and many other signals. These adipose-derived factors are mainly influenced by nutritional transitions. This review addresses essentially the differential regulation and role of animal adipose-secreted products in regulating metabolic, endocrine and behavioral responses during prolonged fasting. When reaching a low adiposity threshold, animals enter late fasting characterized by elevated rates of protein degradation while lipid utilization decreases. Low NEFA levels in late fasting could affect PPAR activation and the management of body reserves, thus promoting food seeking behavior. Low leptin levels are also likely involved in the efficient mobilization of energy stores and in the induction of strong rises in hypothalamic orexigenic neuropeptides in late fasting. This effect is prevented by leptin perfusion. During fasting, adiponectin reduced levels could be related to its ability to signal nutritional and/or metabolic changes, to promote energy preservation or to prepare the body to efficiently restore body weight in case of refeeding while resistin low levels could constitute an adipose status sensor and/or improve glucose homeostasis. The fasting-induced changes of other signals during the fed/fasted/refed transitions are also briefly discussed.

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“…PAI-1 is also induced by CCN-2 (61) in some cells, and it decreases during adipocyte differentiation and can cause insulin resistance (5, 18, 30, 59). In humans, PAI-1 concentration in the circulation is increased with obesity and correlates with various metabolic syndrome-associated measurements, such as waist-to-hip ratio and direct measurements of visceral fat (46,49).…”

mentioning

confidence: 99%