Adipocyte Hormone Responsiveness and Aging in the Rat: Problems in the Interpretation of Aging Research

Kirkland, James L.; Dax, Elizabeth M.

doi:10.1111/j.1532-5415.1984.tb02006.x

Cited by 28 publications

(12 citation statements)

References 97 publications

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“…Substantial changes in fat tissue metabolic function occur during aging, with declines in insulin, lipolytic, and fatty acid responsiveness (Bertrand et al , 1980; Yu et al , 1982; Kirkland & Dax, 1984; Yki-Jarvinen et al , 1986; Silver et al , 1993; Gregerman, 1994; Kirkland & Dobson, 1997; Kirkland et al , 2002; Das et al , 2004; Tchkonia et al , 2006a). Together with preadipocyte dysfunction, impairments in ability to accumulate or mobilize lipid with aging reduce the dynamic range over which fat cells can store or release energy or respond to excess systemic lipotoxic fatty acids.…”

Section: Fat Tissuementioning

confidence: 99%

Fat tissue, aging, and cellular senescence

Tchkonia

Morbeck

Zglinicki³

et al. 2010

Aging Cell

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877

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Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mutations affecting fat increase life span. Fat cells turn over throughout the life span. Fat cell progenitors, preadipocytes, are abundant, closely related to macrophages, and dysdifferentiate in old age, switching into a pro-inflammatory, tissue-remodeling, senescent-like state. Other mesenchymal progenitors also can acquire a pro-inflammatory, adipocyte-like phenotype with aging. We propose a hypothetical model in which cellular stress and preadipocyte overutilization with aging induce cellular senescence, leading to impaired adipogenesis, failure to sequester lipotoxic fatty acids, inflammatory cytokine and chemokine generation, and innate and adaptive immune response activation. These pro-inflammatory processes may amplify each other and have systemic consequences. This model is consistent with recent concepts about cellular senescence as a stress-responsive, adaptive phenotype that develops through multiple stages, including major metabolic and secretory readjustments, which can spread from cell to cell and can occur at any point during life. Senescence could be an alternative cell fate that develops in response to injury or metabolic dysfunction and might occur in nondividing as well as dividing cells. Consistent with this, a senescent-like state can develop in preadipocytes and fat cells from young obese individuals. Senescent, pro-inflammatory cells in fat could have profound clinical consequences because of the large size of the fat organ and its central metabolic role.

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Section: Fat Tissuementioning

confidence: 99%

Fat tissue, aging, and cellular senescence

Tchkonia

Morbeck

Zglinicki³

et al. 2010

Aging Cell

Self Cite

897

877

View full text Add to dashboard Cite

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“…It has been appreciated that fat tissue is regionally heterogeneous with respect to the content of stem cells and metabolic function. 1,2 From the aspect of cell sources of regenerative medicine, the contents and characterization of adiposederived stem cells (ADSCs) isolated from different depots of rats and humans have been reported. [3][4][5][6] Fraser et al 3 reported that adipose tissue from hip yielded 2.3-fold more ADSCs than abdomen, and the cells from hip had more potency to differentiate into osteogenic lineages, suggesting the importance of selection of the harvest depot if one considers to use adipose tissue as a cell sources for regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Characterization and comparison of adipose tissue‐derived cells from human subcutaneous and omental adipose tissues

Toyoda

Matsubara

Lin

et al. 2009

Cell Biochemistry & Function

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Different fat depots contribute differently to disease and function. These differences may be due to the regional variation in cell types and inherent properties of fat cell progenitors. To address the differences of cell types in the adipose tissue from different depots, the phenotypes of freshly isolated adipose tissue-derived cells (ATDCs) from subcutaneous (SC) and omental (OM) adipose tissues were compared using flow cytometry. Our results showed that CD31(-)CD34(+)CD45(-)CD90(-)CD105(-)CD146(+) population, containing vascular smooth muscle cells and pericytes, was specifically defined in the SC adipose tissue while no such population was observed in OM adipose tissue. On the other hand, CD31(-)CD34(+)CD45(-)CD90(-)CD105(-)CD146(-) population, which is an undefined cell population, were found solely in OM adipose tissue. Overall, the SC adipose tissue contained more ATDCs than OM adipose tissue, while OM adipose tissue contained more blood-derived cells. Regarding to the inherent properties of fat cell progenitors from the two depots, adipose-derived stem cells (ADSCs) from SC had higher capacity to differentiate into both adipogenic and osteogenic lineages than those from OM, regardless of that the proliferation rates of ADSCs from both depots were similar. The higher differentiation capacity of ADSCs from SC adipose tissue suggests that SC tissue is more suitable cell source for regenerative medicine than OM adipose tissue.

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“…The amount and distribution of fat are important factors that influence the meat quality in the beef industry [1], [2]. For several decades, it has been known that adipose tissues are regionally heterogeneous with respect to metabolic activities and functions [3]–[5]. Evidences showed that the numerous biological and genetic differences among adipose tissues depend on their anatomical locations [6]–[8].…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specific Adipogenesis in Cattle

et al. 2013

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Adipocytes mainly function as energy storage and endocrine cells. Adipose tissues showed the biological and genetic difference based on their depots. The difference of adipocytes between depots might be influenced by the inherent genetic programing for adipogenesis. We used RNA-seq technique to investigate the transcriptomes in 3 adipose tissues of omental (O), subcutaneous (S) and intramuscular (I) fats in cattle. Sequence reads were obtained from Illumina HiSeq2000 and mapped to the bovine genome using Tophat2. Differentially expressed genes (DEG) between adipose tissues were detected by EdgeR. We identified 5797, 2156, and 5455 DEGs in the comparison between OI, OS, and IS respectively and also found 5657 DEGs in the comparison between the intramuscular and the combined omental and subcutaneous fats (C) (FDR<0.01). Depot specifically up- and down- regulated DEGs were 853 in S, 48 in I, and 979 in O. The numbers of DEGs and functional annotation studies suggested that I had the different genetic profile compared to other two adipose tissues. In I, DEGs involved in the developmental process (eg. EGR2, FAS, and KLF7) were up-regulated and those in the immune system process were down-regulated. Many DEGs from the adipose tissues were enriched in the various GO terms of developmental process and KEGG pathway analysis showed that the ECM-receptor interaction was one of commonly enriched pathways in all of the 3 adipose tissues and also functioned as a sub-pathway of other enriched pathways. However, genes involved in the ECM-receptor interaction were differentially regulated depending on the depots. Collagens, main ECM constituents, were significantly up-regulated in S and integrins, transmembrane receptors, were up-regulated in I. Different laminins were up-regulated in the different depots. This comparative transcriptome analysis of three adipose tissues suggested that the interactions between ECM components and transmembrane receptors of fat cells depend on the depot specific adipogenesis.

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Adipocyte Hormone Responsiveness and Aging in the Rat: Problems in the Interpretation of Aging Research

Cited by 28 publications

References 97 publications

Fat tissue, aging, and cellular senescence

Fat tissue, aging, and cellular senescence

Characterization and comparison of adipose tissue‐derived cells from human subcutaneous and omental adipose tissues

Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specific Adipogenesis in Cattle

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