Adipocitos, obesidad visceral, inflamación y enfermedad cardiovascular

Manzur, Fernando; Alvear, Ciro; Alayón, Alicia Norma

doi:10.1016/s0120-5633(10)70243-6

Cited by 13 publications

(14 citation statements)

References 34 publications

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Section: Epicardial Fat and Vasocrine Regulationmentioning

confidence: 99%

“…Due to the known plasticity of adipocytes observed in their preadipocyte differentiation into macrophages and hypertrophy/hyperplasia of differentiated adipocytes, epicardial adipocyte undergoes various changes as well [ 70 , 101 ]. These morphofunctional changes generate hypersecretion of proinflammatory and proatherogenic adipocytokines, associated with decreased production of adiponectin and adrenomedullin [ 101 , 102 ]. One of the changes observed in enlarged adipocytes is an increased production of saturated free fatty acids (FFA), which bind to TLR-4 in macrophages resulting in the activation of NF- κβ and enhanced synthesis of TNF- α [ 103 , 104 ].…”

Section: Epicardial Fat and Vasocrine Regulationmentioning

confidence: 99%

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Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Salazar

Luzardo

Mejías

et al. 2016

Cardiology Research and Practice

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Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue's behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation. The participation of these adipokines generates a state of persistent vasoconstriction, increased stiffness, and weakening of the coronary wall, consequently contributing to the formation of atherosclerotic plaques. Therefore, epicardial adipose tissue thickening should be considered a risk factor in the development of cardiovascular disease, a potential therapeutic target for cardiovascular pathology and a molecular point of contact for “endocrine-cardiology.”

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Section: Epicardial Fat and Vasocrine Regulationmentioning

confidence: 99%

Section: Epicardial Fat and Vasocrine Regulationmentioning

confidence: 99%

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Salazar

Luzardo

Mejías

et al. 2016

Cardiology Research and Practice

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“…Algunos autores refieren que la inflamación es consecuencia de la obesidad, se sugiere también que la obesidad se puede producir como consecuencia de un proceso inflamatorio (10,11,12) . Los adipocitos y los macrófagos comparten varias características, dentro de ellas los productos de expresión de sus genes y su capacidad funcional, ya que los macrófagos pueden almacenar lípidos y los preadipocitos exhibir propiedades fagocíticas y antimicrobianas, llegando a poder diferenciarse en macrófagos (4,11,12) .…”

Section: Discussionunclassified

“…En la tabla 3 se observa diferencia significativa cuando se analizaron las muestras emparejadas de los participantes tanto en Trujillo como Chimborazo, lo que explicaría una relación directa entre el índice de masa corporal y los niveles de PCR, IL-6, inhibidor del plasminógeno tisular (PAI-1), moléculas de adhesión (P-selectina, ICAM, VCAM-1) y factores quimiotácticos (MCP-1), los que favorecen la adhesión, migración y acumulación de monocitos y linfocitos T en el espacio subendotelial a consecuencia de la alteración de la permeabilidad vascular (4) .…”

Section: Discussionunclassified

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Influencia de la altura en los niveles de proteína C reactiva en adultos con adiposidad visceral abdominal

et al. 2018

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Objetivo: Evaluar la influencia de la altura en los niveles de proteína C reactiva (PCR) en adultos con adiposidad visceral abdominal. Materiales y métodos: Se realizó un estudio cuantitativo con diseño cuasi-experimental, que incluyó veinticuatro estudiantes de medicina de la Universidad Nacional de Trujillo, sexo masculino, seleccionados de manera no probabilística por conveniencia y sujeto participante, que fueron evaluados a 0 y 4386 m s. n. m. y clasificados de acuerdo al grado de adiposidad visceral abdominal: normal (G1) y elevada (G2). Resultados: El nivel de PCR de G1 en relación a G2 no tuvo diferencia significativa. Respecto a los niveles de PCR de G2 se empleó la prueba no paramétrica de Wilcoxon y para G1 se usó la prueba T-student, evidenciándose una significancia en ambos casos. Conclusiones: Las variaciones de los niveles de PCR en altura con respecto al basal de ambos grupos fueron significativos.

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Three-wavelength PPG and support vector machine for non-invasive estimation of blood glucose

et al. 2023

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Diabetes mellitus is a chronic disease characterized by producing abnormal levels of blood glucose concentration. Currently, the most widely accepted method for glucose monitoring is invasive, however, despite its great reliability, it can be uncomfortable and traumatizing for the youngest users. The objective of this study is to provide an alternative method that allows a non-invasive estimation of blood glucose levels with an elevated level of con dence. In this work, 187 records were performed on people without any declared pathology; the concentration of blood glucose and the amplitude of the PPG signals of 525 nm, 660 nm and 940 nm were measured simultaneously. 70% of the data was used to train a regression model based on a ne Gaussian support vector machine, while the remaining 30% is used to validate the results. The regression model using the support vector machine was able to locate 95.38% of the estimates with an error of less than 15%, showing a standard error of 7.01 mg/dL and a MARD of 6.99%.The model presented here allows non-invasive estimation of blood glucose levels with reliability comparable to minimally invasive devices currently on the market.

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Adipocitos, obesidad visceral, inflamación y enfermedad cardiovascular

Cited by 13 publications

References 34 publications

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Influencia de la altura en los niveles de proteína C reactiva en adultos con adiposidad visceral abdominal

Three-wavelength PPG and support vector machine for non-invasive estimation of blood glucose

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