Adipocitocinas: uma nova visão do tecido adiposo

Guimarães, Daniella Esteves Duque; Sardinha, Fátima Lúcia de Carvalho; Mizurini, Daniella M.; Carmo, Maria das Graças Tavares do

doi:10.1590/s1415-52732007000500010

Cited by 42 publications

(49 citation statements)

References 65 publications

(61 reference statements)

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“…Discovered in 1994 [10], it is an Ob gene product [11], cloned and sequenced in mice and considered the adipokine responsible for the regulation of energy metabolism and homeostasis, as well as neuroendocrine functions [12]. It also assists the immunity and inflammation control through its receptor [13].…”

Section: Leptinmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

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Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

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Section: Leptinmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

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“…IL-6 is a physiological regulator that has several functions in different organs, including the central nervous system, cardiovascular, immune and hepatic systems, among others; its dysregulation affects several pathological conditions (Hong et al 2007, Guimarães et al 2007.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

Todendi

Klinger

Ferreira

et al. 2015

An. Acad. Bras. Ciênc.

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Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction (PCR). Anthropometric characteristics, biochemical markers, immunological markers and blood pressure were assessed. Descriptive statistics, chi-square and logistic regression were used for the analyses. No association was detected between the rs1800795 polymorphism and the assessed variables. Individuals with the risk genotype in the rs1205 gene were associated with the risk of developing hypercholesterolemia (OR 2.79; CI 1.40, 5.57; p = 0.003). Carriers of the risk genotype in the rs2069845 gene are associated with the risk of developing obesity (OR 3.07; CI 1.08, 8.72; p = 0.03). The polymorphism rs2069845 was associated with obesity and rs1205 was associated with the risk of developing hypercholesterolemia in Brazilian schoolchildren.

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“…After four weeks of exposure to this hyperlipidic diet, there was significant increase in body weight of the animals from the obese group and reduction in the insulin sensitivity when compared with the animals from the control group (figures 2 and 3), which only received standard chow as food, highlighting the obesogenic effect of the diet 22 and the correlation between obesity and metabolic alterations caused by fat excess 25 . The cytokines released by the excessive adipose tissue may generate a scenario of peripheral systemic inflammation 26,27 , altering the insulin signaling and initiating a possible insulin resistant status 28 . Obesity, besides altering the physiological functions 28 , may be considered as a limiting factor for exercise tests performance, even in animals.…”

Section: Discussionmentioning

confidence: 99%

Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

Brandão¹,

Souza²,

Trombetta³

et al. 2013

Rev Bras Med Esporte

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Introduction: The literature lacks studies about lactate actions and some limitations in studies involving healthy individuals or patients with some metabolic disorder. Objectives: This study aimed to evaluate the protocol of double effort test for obese-induced rats. Methods: Fourteen male Wistar rats were divided into two groups: Control (Con) and Obese (Obe). The control group was fed with standard chow and water ad libitum. The obese group was fed with standard chow, water ad libitum and hyperlipidic diet. Twelve weeks after the beginning of the hyperlipidic diet, insulin tolerance test, Maximal Lactate Steady State (MLSS) test and the double efforts test were performed. Results: The diet was effective to promote obesity. The obese group decreased insulin sensitivity in approximately 19% (Con = 2.156 ± 0.1187 AU vs Obe = 1.742 ± 0.1551 AU). The lactate concentration and velocity of anaerobic threshold at MLSS test were 3.780 ± 0.09 mmol/L e 18 m.min -1 in both groups. The velocity of anaerobic threshold estimated by double efforts test was 15.59±0.653 m.min -1 in Con group control animals and 16.42±0.672 m.min -1 in Obe group. The double effort test underestimated around 13% and 8.7% the aerobic capacity in control and obese groups respectively, however, presented significant correlation with MLSS (r = 0,88; P < 0,0075 controls / r = 0,92; P < 0,0031 obese). Conclusion: So, the double effort test can be an interesting alternative to evaluate the aerobic capacity for both healthy sedentary and obese animals.

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Adipocitocinas: uma nova visão do tecido adiposo

Cited by 42 publications

References 65 publications

Adipokines in rheumatoid arthritis

Adipokines in rheumatoid arthritis

Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

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