Adhesive strength of bone-implant interfaces and in-vivo degradation of PHB composites for load-bearing applications

Meischel, Martin; Eichler, Jens; Martinelli, Elisabeth; Karr, Ulrike; Weigel, Joseph P.; Schmöller, G.; Tschegg, E. K.; Fischerauer, Stefan; Weinberg, Annelie M.; Stanzl-Tschegg, Stefanie E.

doi:10.1016/j.jmbbm.2015.08.004

Cited by 66 publications

(36 citation statements)

References 53 publications

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“…The P(3HB) hydrolytic degradation product, D-(-)-3-hydroxybutyric acid, is an usual metabolite in all living beings 11 . Different from the others biodegradable polymers, P(3HB) doesn't change the region pH while being degradaded 12 . However, it has a slow degradation rate 13 .…”

Section: Introductionmentioning

confidence: 92%

Influence of Encapsulated Nanodiamond Dispersion on P(3HB) Biocomposites Properties

et al. 2017

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Studies regarding biodegradable nanocomposites to be used as orthopedics devices have been intensified. This work aims to investigate the influence of ND dispersion on thermal and mechanical properties of a biocomposite of poly(3-hydroxybutyrate) (P(3HB)) reinforced with nanodiamonds (ND) intended to be used as orthopedics devices, with advantages as biodegradability. In order to improve its dispersion, P(3HB) has encapsulated ND in three different mass ratios: P(3HB):ND(16:1), (12:1) and (8:1). However, for all formulations, NDs are presented as agglomerates, in different intensities. In order to relate the distribution of ND within the polymer matrix and biocomposite properties, TGA, DSC, and DMA analysis were done. The formulation with higher content of ND, P(3HB):ND(8:1), presents larger aggregates; thus, decreasing its properties. With smaller and more distributed agglomerates, the 12:1 ratio composite displayed superior storage modulus and glass transition temperature, probably due to better polymer chain restriction.

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Section: Introductionmentioning

confidence: 92%

Influence of Encapsulated Nanodiamond Dispersion on P(3HB) Biocomposites Properties

et al. 2017

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“…Studies using biodegradable polymers such as PHB has attracted attention since it can be applied in industries such as packaging 4,5 , agriculture 3 and biomedical because they are biocompatible and provide adequate mechanical properties for application 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate Composites with Random Mats of Sisal and Coconut Fibers

et al. 2016

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Biodegradable polymeric composites using natural fibers have been investigated aiming to mitigate environmental impacts. In this paper, polyhydroxybutyrate (PHB) composites obtained using random mats of sisal and coconut fibers by compression molding in a hydraulic press, and the fiber content varied between 10% and 15% relative to the weight of the polymer. Thermal analyses were performed such as Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). Flexural and tensile tests were performed before and after conditioning in climate chamber with temperature and moisture. The results of thermal analysis show that the thermal stability of the materials remained, both PHB without fiber as for composites with natural fibers mats. The results of mechanical tests indicated that the PHB without fibers and composites showed similar flexural strength values, while the results of the tensile test PHB without fibers showed resistance to higher tensile composite.

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“…The latest study evaluated the response of bone to novel biodegradable polymeric composite implants made of PHB and Herafill ® (37). Herafill ® is a composite made of calcium sulfate (CaSO 4 ), calcium carbonate (CaCO 3 ) and glycerol tripalmitate (37). It was clinically used as an alternative bone substitute material with proven osteoconductivity (38).…”

Section: Physicochemical Modifications Of Phb In the Field Of Bone Timentioning

confidence: 99%

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

Dariš

Knez

2019

Acta Pharmaceutica

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Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biode gradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physicochemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxy apatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their bio com patibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxybutyrate) patches were implanted in vivo in bone tissue of cats, mini pigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.

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Adhesive strength of bone-implant interfaces and in-vivo degradation of PHB composites for load-bearing applications

Cited by 66 publications

References 53 publications

Influence of Encapsulated Nanodiamond Dispersion on P(3HB) Biocomposites Properties

Influence of Encapsulated Nanodiamond Dispersion on P(3HB) Biocomposites Properties

Polyhydroxybutyrate Composites with Random Mats of Sisal and Coconut Fibers

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

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