Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment

Lee, Jong Min; Ryu, Gi-Hyung; Kim, Eun Ah; Jo, Seongyeon; Kim, Byung Soo; Lee, Haeshin; Im, Gun‐Il

doi:10.1016/j.biomaterials.2014.11.006

Cited by 43 publications

(23 citation statements)

References 37 publications

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“…For example, in cartilage defects, the migration and retention of a large population stem cells from the bone marrow into the defect site is a major key to promote successful tissue regeneration. To achieve this goal, Lee et al designed a water-resistant catechol-conjugated chitosan (CHIeC)-adhesive gel patch [94]. The system was capable of delivering platelet-derived growth factor-AA (PDGF-AA) with specificity to defects created in the bone marrow cavities of rats.…”

Section: Strategies To Achieve Stem and Progenitor Cell Recruitmentmentioning

confidence: 99%

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Pacelli

Basu

Whitlow

et al. 2017

Advanced Drug Delivery Reviews

128

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A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate the body’s repair mechanisms through the recruitment of endogenous stem cells to sites of injury. Approaches that employ the use of chemoattractant gradients to guide tissue regeneration without external cell sources are favored over traditional cell-based therapies that have limited potential for clinical translation. Following this concept, bioactive scaffolds can be engineered to provide a temporally and spatially controlled release of biological cues, with the possibility to mimic the complex signaling patterns of endogenous tissue regeneration. Another effective way to regulate stem cell activity is to leverage the inherent chemotactic properties of extracellular matrix (ECM)-based materials to build versatile cell-instructive platforms. This review introduces the concept of endogenous stem cell recruitment, and provides a comprehensive overview of the strategies available to achieve effective cardiovascular and bone tissue regeneration.

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Section: Strategies To Achieve Stem and Progenitor Cell Recruitmentmentioning

confidence: 99%

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Pacelli

Basu

Whitlow

et al. 2017

Advanced Drug Delivery Reviews

128

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“…25 When pharmacologically delivered to the body globally, however, some GFs, such as IGF-1, can trigger systemic adverse events. [26][27][28] Local delivery of such GFs by functionalization to scaffolds or particles, 24,29 encapsulation in microspheres, 20,30 or the development of fusion proteins 31 have extended the viability of these GFs as useful tissue engineering tools. The fusion protein heparin-binding insulinlike growth factor-1 (HB-IGF-1), for example, stimulates matrix production by chondrocytes through a single dose delivered through a self-assembling peptide hydrogel scaffold.…”

Section: Introductionmentioning

confidence: 99%

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Liebesny

Byun

Hung

et al. 2016

Tissue Engineering Part A

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Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor release kinetics. The objective of this study was to identify a growth factor combination that accelerates progenitor cell migration into self-assembling peptide hydrogels in the context of cartilage defect repair. A novel 3D gel-to-gel migration assay enabled quantification of the chemotactic impact of platelet-derived growth factor-BB (PDGF-BB), heparin-binding insulin-like growth factor-1 (HB-IGF-1), and transforming growth factorb1 (TGF-b1) on progenitor cells derived from subchondral bovine trabecular bone (bone-marrow progenitor cells, BM-PCs) encapsulated in the peptide hydrogel [KLDL] 3 . Only the combination of PDGF-BB and TGF-b1 stimulated significant migration of BM-PCs over a 4-day period, measured by confocal microscopy. Both PDGF-BB and TGF-b1 were slowly released from the gel, as measured using their 125

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“…The second property of chitosan–catechol patches provides a diffusion barrier 58. The barrier formed with blood prevents drug release from the barrier side.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine and Its Derivative Surface Chemistry in Material Science: A Focused Review for Studies at KAIST

2020

Self Cite

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Polydopamine coating, the first material‐independent surface chemistry, and its related methods significantly influence virtually all areas of material science and engineering. Functionalized surfaces of metal oxides, synthetic polymers, noble metals, and carbon materials by polydopamine and its related derivatives exhibit a variety of properties for cell culture, microfluidics, energy storage devices, superwettability, artificial photosynthesis, encapsulation, drug delivery, and numerous others. Unlike other articles, this review particularly focuses on the development of material science utilizing polydopamine and its derivatives coatings at the Korea Advanced Institute of Science and Technology for a decade. Herein, it is demonstrated how material‐independent coating methods provide solutions for challenging problems existed in many interdisciplinary areas in bio‐, energy‐, and nanomaterial science by collaborations and independent research.

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Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment

Cited by 43 publications

References 37 publications

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Polydopamine and Its Derivative Surface Chemistry in Material Science: A Focused Review for Studies at KAIST

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