Adhesive and In Vitro Release Properties of the Konjac Glucomannan and Xanthan Gum Mixture Gel Film

Abstract

Purposes: To study the adhesive and the in vitro release properties of a mixture gel film prepared with two kinds of natural polysaccharides -konjac glucomannan and xanthan gum. Methods: The optimal formula was investigated by the quadratic regression rotatable orthogonal design with adhesive force as the evaluated parameter. Its in vitro release behavior was studied by the in vitro accumulative released curve with aciclovir as the model medicine. Results: By predication and verification, the optimal formula for film-forming was determined as follows: 50 mL of mixture gel of 1 %(w/w) konjac glucomannan and 1 % (w/w) xanthan gum solution at the ratio of 2.36:1 (v/v), added 0.35 mL of glycerol and 0.47 mL of Tween-80, the forming film possessed the optimal adhesive ability, and the adhesive force for each piece was (50.85±3.57) g ( n=6 ) . The release of aciclovir from the medicinal film reached the maximum at 4.5 h, and could maintain 3-7 h. Conclusions: The konjac glucomannan and xanthan gum mixture gel film possesses good bio-adhesive and controlled-release abilities, and the results indicated that it could be a promising matrix material for the mucosa adhesive and transdermal drug delivery systems.

A Review on Konjac Glucomannan Gels: Microstructure and Application

“…Synergistic reaction between KGM and other polysaccharide is another method for preparing KGM-based hydrogels, KGM-κ-carrageenan and KGM-xanthan gum (XG) hydrogels had been reported in previous researches, but their microstructure had not reported [ 39 , 40 , 41 , 42 ]. Zhang et al [ 43 ] used two natural polysaccharides—KGM and XG—to prepare a mixed gel film for use as a matrix material for mucosal adhesives and transdermal drug delivery systems. Estimation and experimental verification suggested that the optimum formulation was as follows: 50 mL of 1% ( w / w ) KGM and 1% ( w / w ) XG solution were used to prepare the mixed gel at a ratio of 2.36:1 ( v / v ).…”

Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature

“…It consists of random distribution of β-(1-4)-linked D-glucose and β-(1-4)-linked D-mannose in the backbone (Figure 4) (Gopinath et al, 2018). Zhang et al(2010) fabricated gel film of acyclovir with konjac glucomannan and xanthan gum. The optimized film composed of konjac glucomannan and xanthan gum at a ratio 2.36:1 (v/v) displayed optimal adhesive ability.…”

“…The optimized film composed of konjac glucomannan and xanthan gum at a ratio 2.36:1 (v/v) displayed optimal adhesive ability. The release of the drug from the optimized film showed a peak at 4.5 h and could maintain for 3-7 h. Thus, the above film had good bioadhesive property along with controlled-release abilities (Zhang et al, 2010). Types of polysaccharides with various formulations, incorporated drugs, and used for the treatment are presented in Table I.…”