Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Abstract

Marine-derived polymers are environmentally friendly and sustainable biomaterials that have structural similarities with the main components of the extracellular matrix. Moreover, some marine polymers have specific bioactivity that can be transferred to the systems made of these biomolecules. Herein, we developed antibacterial adhesive films combining two marine polysaccharides, namely, fucoidan and chitosan. Fucoidan was functionalized with catechol groups (FCat) to improve its adhesive properties. This modification enhanced also the fucoidan antibacterial properties: while fucoidan is active against Gram-positive bacteria, FCat showed bactericidal activity against Gram-positive and Gram-negative bacteria. To improve the processability and mechanical properties, FCat was blended with chitosan and solvent-casted to obtain films. These films exhibited an adhesion strength similar to the one of clinically used natural adhesives and no cytotoxicity: fibroblastic cells attached and remained viable on the films. Altogether our results demonstrated that the developed antibacterial and adhesive films are a feasible alternative of cytotoxic synthetic adhesives used for soft tissue healing applications.

Phosphate starvation stops bacteria digesting algal fucan that sequesters carbon

“…Only second follows innovation to increase carbon dioxide removal and storage capacity 7 . Diatoms 2 and brown algae synthesize an extracellular matrix 8 that contains fucoidan, a sulfated fucan with antibacterial 9 , antiviral 10 and antifouling activity 11,12 . Algal blooms accumulate dissolved and particulate fucan.…”

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

“…In addition, the mentioned chitosan films retain the inherent antibacterial properties of chitosan, making them effective in preventing bacterial growth [ 162 ]. This is especially useful in applications like wound dressings where infection prevention is crucial [ 163 ]. Moreover, the films can be used as drug delivery systems, with the drug incorporated within the film and released over time [ 164 ].…”

Boiling water resistant fully bio-based adhesive made from maleated chitosan and glucose with excellent performance

“…Based on the fact that chitosan is the only basic polysaccharide among natural polysaccharides, it has excellent biological properties and can be chemically modi ed [21]. Chitosan has been chemically modi ed to improve its utilization, making it widely used in medicine, nanomaterials, food packaging, and other elds [22][23][24][25]. Like other biomass materials, chitosan has the potential to be used as an adhesive in the wood industry.…”