Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings

Strauß, Sarah; Neumeister, Anne; Barcikowski, Stephan; Kracht, Dietmar; Kuhbier, Joern W.; Radtke, Christine; Reimers, Kerstin; Vogt, Peter M.

doi:10.1371/journal.pone.0053309

Cited by 23 publications

(15 citation statements)

References 34 publications

(55 reference statements)

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“…Significant high repairing strength, resistance to gap formation and rapid healing with enhanced clinical outcomes on tendon repair can expand its use for critical orthopaedic injuries . Stem cell modified metallic sutures through nanocoatings with shape‐memory alloy (Nitinol) can broaden its clinical use for orthopaedic application …”

Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

139

108

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Surgical sutures are used to facilitate closure and healing of surgical-or trauma-induced wounds by upholding tissues together to facilitate healing process. There is a wide range of suture materials for medical purpose and the main types include absorbable and nonabsorbable. Recently, there is a growth in the development of classes of suture materials based on their properties and capabilities to improve tissue approximation and wound closure. This review outlines and discusses the current and emerging trends in suture technology including knotless barbed sutures, antimicrobial sutures, bio-active sutures such as drug-eluting and stem cells seeded sutures, and smart sutures including elastic, and electronic sutures. These newer strategies expand the versatility of sutures from being used as just a physical entity approximating opposing tissues to a more biologically active component enabling delivery of drugs and cells to the desired site with immense application potential in both therapeutics and diagnostics.

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Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

139

108

View full text Add to dashboard Cite

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“…5 He et al created ZnO films from ZnO nanoparticles in water to characterize the composition and also the charge of ZnO generated in water. 34 Strauß et al also used nanoparticles synthesized by PLAL for the deposition on biomaterials like stents 35 and to study the influence of ligands on electrophoretic mobility. 47 However, to the authors knowledge the fundamentals of EPD with laser generated nanoparticles e.g.…”

mentioning

confidence: 99%

Continuous Electrophoretic Deposition and Electrophoretic Mobility of Ligand-Free, Metal Nanoparticles in Liquid Flow

Koenen

Streubel

Jakobi

et al. 2015

J. Electrochem. Soc.

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Direct current electrophoretic deposition (DC-EPD) of ligand-free metal nanoparticles in a flow-through reactor is studied by analyzing the educt colloid and the outflow of the flow through chamber while the concentration of the colloid and the strength of the electric field is varied. Metal nanoparticles synthesized by pulsed laser ablation in liquid (PLAL) are used to ensure that the colloidal nanoparticle surface is free of any ligands and that the colloid's stability and movement in an electric field is solely influenced by electrostatic forces. Electrophoretic mobility and deposition kinetics of these ligand-free nanoparticles on plain surfaces are examined for different electric field strengths. Additionally, a continuous liquid flow DC-EPD process is presented and optimized regarding deposition rate, colloid stability, and liquid flow rate. The reported parameter window for high deposition rates of nanoparticles without a negative impact on the colloid, allows to define an efficient stationary EPD process suitable for high throughput applications.Electrophoretic deposition (EPD) is a process in which charged colloidal nanoparticles are guided by an applied electric field in order to adsorb suitable particles on an adsorbant substrate. An often-used application is the deposition of nanoparticles to create nano-and microstructures. 1 Electrophoretic deposition generally requires a system containing two electrodes. 2 Charged particles move in liquid in the direction of the oppositely charged electrode. During EPD, electrophoresis of charged particles in solution is followed by adsorption or assembling of particles on the oppositely charged electrode. [2][3][4] This electrode is also the desired product of the EPD-based nanostructuring, e.g. for use as a medical device like a nanostructured neural electrode. 5 EPD is a relatively simple and cost efficient technique. Therefore, it is highly suitable for coatings of a broad range of materials e.g. metals or biomaterials. 5-9 As the applied electric field is directed perpendicularly to the curved surface of a shaped target and the particles follow this direction (with some limitations), EPD is predestined for controlled and fast coating of 3-dimensional materials. 10 Since first experiments in the field of electrophoresis were performed by Bose in 1740 11 the process of EPD was studied by several researchers (which is reviewed elsewhere). 1 The first study concerning the rate of nanoparticle deposition on a substrate was investigated by Hamaker in 1940. 12 Since then EPD has been established as a reliable and promising application technique. [13][14][15] Despite these different studies on the field of EPD there is still a need for a better understanding of the process itself. As a consequence, a suitable model system for EPD is desirable.EPD of nanoparticles is often carried out with a variety of different surfactants or ligands like citrate, polymers or other additives, which may, at least partially, block the particle's surface. 7,16 The approach in this work i...

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“…The relatively low cellular proliferation and viability exhibited by HTMCs grown on nitinol are similar to what has been observed in vascular cells in vitro . Similar to HTMCs, decreased proliferation has been observed in endothelial cells cultured on nitinol compared with glass control . Furthermore, another study by Shih et al found that nitinol corrosion products inhibit rat aortic smooth muscle cell proliferation .…”

Section: Discussionmentioning

confidence: 89%