Adhesion Specificities of Plasmodium falciparum-Infected Erythrocytes Involved in the Pathogenesis of Pregnancy-Associated Malaria

Hviid, Lars

doi:10.2353/ajpath.2007.070246

Cited by 6 publications

(2 citation statements)

References 23 publications

(24 reference statements)

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“…These findings compel comparisons to the placental damage and inflammation that are underlying the clinical manifestations observed in humans [5] – [10] . Moreover, cytoadherence assays support the hypothesis that P. berghei -GFP iRBC encounter placental receptors that promote specific binding in analogy to the proposed placenta sequestration mechanism for P. falciparum [40] , [41] .…”

Section: Discussionsupporting

confidence: 54%

Pregnancy Outcome and Placenta Pathology in Plasmodium berghei ANKA Infected Mice Reproduce the Pathogenesis of Severe Malaria in Pregnant Women

et al. 2008

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Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that include increased disease severity in pregnant women, decreased fetal viability, intra-uterine growth retardation, low birth weight and infant mortality. The physiopathology of malaria in pregnancy is difficult to scrutinize and attempts were made in the past to use animal models for pregnancy malaria studies. Here, we describe a comprehensive mouse experimental model that recapitulates many of the pathological and clinical features typical of human severe malaria in pregnancy. We used P. berghei ANKA-GFP infection during pregnancy to evoke a prominent inflammatory response in the placenta that entails CD11b mononuclear infiltration, up-regulation of MIP-1 alpha chemokine and is associated with marked reduction of placental vascular spaces. Placenta pathology was associated with decreased fetal viability, intra-uterine growth retardation, gross post-natal growth impairment and increased disease severity in pregnant females. Moreover, we provide evidence that CSA and HA, known to mediate P. falciparum adhesion to human placenta, are also involved in mouse placental malaria infection. We propose that reduction of maternal blood flow in the placenta is a key pathogenic factor in murine pregnancy malaria and we hypothesize that exacerbated innate inflammatory responses to Plasmodium infected red blood cells trigger severe placenta pathology. This experimental model provides an opportunity to identify cell and molecular components of severe PAM pathogenesis and to investigate the inflammatory response that leads to the observed fetal and placental blood circulation abnormalities.

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Section: Discussionsupporting

confidence: 54%

Pregnancy Outcome and Placenta Pathology in Plasmodium berghei ANKA Infected Mice Reproduce the Pathogenesis of Severe Malaria in Pregnant Women

et al. 2008

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“…[ 46 ] Sequestration of P. falciparum in the placenta has been attributed to the ability of the infected RBC to adhere to the glycosaminoglycans chondroitin sulfate A (CSA) and hyaluronic acid (HA), both of which are present on placental syncytiotrophoblasts. [ 47 ] A further interaction between infected RBC and neonatal Fc receptors via surface bound non‐immune immunoglobulin G (IgG) has also been suggested and it seems likely there are also other receptors involved in placental sequestration. [ 48 ]…”

Section: Host‐parasite Interaction During Plasmodium Falciparum Infec...mentioning

confidence: 99%

Novel secretory organelles of parasite origin ‐ at the center of host‐parasite interaction

Bekić,

Kilian

2023

BioEssays

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Reorganization of cell organelle‐deprived host red blood cells by the apicomplexan malaria parasite Plasmodium falciparum enables their cytoadherence to endothelial cells that line the microvasculature. This increases the time red blood cells infected with mature developmental stages remain within selected organs such as the brain to avoid the spleen passage, which can lead to severe complications and cumulate in patient death. The Maurer's clefts are a novel secretory organelle of parasite origin established by the parasite in the cytoplasm of the host red blood cell in order to facilitate the establishment of cytoadherence by conducting the trafficking of immunovariant adhesins to the host cell surface. Another important function of the organelle is the sorting of other proteins the parasite traffics into its host cell. Although the organelle is of high importance for the pathology of malaria, additional putative functions, structure, and genesis remain shrouded in mystery more than a century after its discovery. In this review, we highlight our current knowledge about the Maurer's clefts and other novel secretory organelles established within the host cell cytoplasm by human‐pathogenic malaria parasites and other parasites that reside within human red blood cells.

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Malaria

Richie¹,

Parekh²

2009

Vaccines for Biodefense and Emerging and Neglected Diseases

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Adhesion Specificities of Plasmodium falciparum-Infected Erythrocytes Involved in the Pathogenesis of Pregnancy-Associated Malaria

Cited by 6 publications

References 23 publications

Pregnancy Outcome and Placenta Pathology in Plasmodium berghei ANKA Infected Mice Reproduce the Pathogenesis of Severe Malaria in Pregnant Women

Pregnancy Outcome and Placenta Pathology in Plasmodium berghei ANKA Infected Mice Reproduce the Pathogenesis of Severe Malaria in Pregnant Women

Novel secretory organelles of parasite origin ‐ at the center of host‐parasite interaction

Malaria

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